天然生物材料體外降解研究

1、天然生物材料體外降解研究Research onNatural biological materials in vitro degradation王茂秋 0943012030 曾子繁 0943012013王建忠 0943012028 易 洪 0943012029一、維普數(shù)據(jù)庫檢索檢索式：M=（生物+材料）*K=降解檢索結(jié)果：1/40【題名】熱處理對聚己二酸丁二酯多晶結(jié)構(gòu)和降解行為的影響【作者】趙麗芬1,2 蔣妮1 甘志華1【刊名】高等學(xué)?；瘜W(xué)學(xué)報(bào).2011,32(1).-185-189【文摘】通過熔融結(jié)晶并結(jié)合退火處理方法得到多晶結(jié)構(gòu)的聚己二酸丁二酯（PBA）及具有不同熱歷史的熱力學(xué)穩(wěn)定的晶型,

2、采用廣角X射線衍射儀（WAXD）、原子力顯微鏡（AFM）和差示掃描量熱儀（DSC）研究了PBA的多晶結(jié)構(gòu)、晶體尺寸和結(jié)晶形貌,跟蹤了退火處理PBA的生物降解行為.結(jié)果表明,分子鏈在相同晶格排列中圍繞c軸空間取向的不同是決定多晶PBA降解速率差別的根本因素.2/40【題名】生物酶降解米糠釋放阿魏酸工藝條件優(yōu)化【作者】王謙 李夏蘭 程珊影 方柏山【刊名】華僑大學(xué)學(xué)報(bào)：自然科學(xué)版.2011,32(1).-62-66【文摘】采用均勻設(shè)計(jì)法設(shè)計(jì)和二次多項(xiàng)式逐步回歸分析,優(yōu)化一株放線菌降解米糠釋放反式阿魏酸的培養(yǎng)基配方,并采用單因素法優(yōu)化發(fā)酵條件.優(yōu)化后培養(yǎng)基配方：米糠質(zhì)量分?jǐn)?shù)為6%,米糠粒徑0.50mm

3、,酵母粉質(zhì)量分?jǐn)?shù)為1.0%;優(yōu)化后的發(fā)酵條件：發(fā)酵溫度為28,搖床轉(zhuǎn)速200r.min-1,裝液系數(shù)為12%,接種量的體積分?jǐn)?shù)為3.3%,pH值8.0.實(shí)驗(yàn)結(jié)果表明,反式阿魏酸的釋放率最高為14.55%,與優(yōu)化前相比,釋放率提高了106.7%.研究阿魏酸酯酶和木聚糖酶聯(lián)合作用于米糠產(chǎn)阿魏酸和低聚糖的協(xié)同效應(yīng),阿魏酸釋放率達(dá)到20.22%,與阿魏酸酯酶單獨(dú)降解米糠相比,其釋放率提高了119.1%;低聚木糖的釋放量2.04mg.mL-1,與木聚糖酶單獨(dú)降解米糠相比,其釋放量提高了87.2%.3/40【題名】凝膠滲透色譜法研究殼聚糖生物材料酶降解過程的均勻性【作者】任東文1,2 衣洪福1,2 謝威揚(yáng)

4、1 馬小軍1【刊名】色譜.2006,24(4).-407-410【文摘】殼聚糖是一種重要的生物醫(yī)用材料，脫乙酰度是影響其生物降解性能的重要因素。運(yùn)用凝膠滲透色譜研究了脫乙酰度及相對分子質(zhì)量分布相似、而聚合單元N-乙酰氨基-D-葡萄糖和D-氨基葡萄糖分布不同的兩種殼聚糖材料在溶菌酶作用下的降解過程，分析檢測了殼聚糖材料在降解過程中的重均相對分子質(zhì)量、相對分子質(zhì)量多分散性和相對分子質(zhì)量分布的變化。發(fā)現(xiàn)聚合單元為隨機(jī)分布的殼聚糖樣品，其降解是均勻的；而聚合單元為段狀分布的殼聚糖樣品，其降解是非均勻的；表明其聚合單元的分布方式?jīng)Q定殼聚糖材料酶降解過程的均勻性。4/40【題名】脫鈣松質(zhì)骨的骨支架材料制備

5、及其生物學(xué)檢測【作者】楊淵1 林春博1 陳維平1,2【刊名】中國組織工程研究與臨床康復(fù).2010,14(47).-8769-8772【文摘】背景：脫鈣松質(zhì)骨的主要成分是膠原,由于其良好的三維空間及促進(jìn)細(xì)胞增殖分化的生長因子,使其具有傳導(dǎo)成骨和誘導(dǎo)成骨的雙重功能,但是目前沒有修訂出一個(gè)規(guī)范科學(xué)的制備流程。目的：采用新方法制備兔脫鈣松質(zhì)骨,并檢測其孔隙率、降解率及其生物相容性,對其能否作為組織工程的支架材料進(jìn)行評估。方法：在Urist方法的基礎(chǔ)上采用新方法制備新西蘭兔脫鈣松質(zhì)骨,并對脫鈣松質(zhì)骨的空隙率、體外降解率、以及細(xì)胞活力和誘導(dǎo)骨髓間充質(zhì)干細(xì)胞成骨能力進(jìn)行檢測。實(shí)驗(yàn)分為脫鈣3h,脫鈣24h和脫

6、鈣48h組,其他的處理步驟3組都相同。結(jié)果與結(jié)論：脫鈣3,24,48h組的孔隙率分別為76.56%,81.25%,84.38%。完全降解所需時(shí)間分別為64,59,53d。細(xì)胞在種植后13d為生長滯留期,第5天達(dá)到對數(shù)生長期,以后進(jìn)入到平臺(tái)期。誘導(dǎo)后的骨髓間充質(zhì)干細(xì)胞行堿性磷酸酶染色呈陽性。結(jié)果提示,新方法制備的脫鈣松質(zhì)骨對細(xì)胞無毒害作用,在生物學(xué)特性上達(dá)到骨組織工程支架材料的要求。5/40【題名】-己內(nèi)酯與L-丙交酯共聚物降解性能及其生物相容性【作者】高喜翔1 張建1 陳兵1 俞恒錫1 李建新1 張淑文1 孟艷1 韓健2 葉霖2 馮增國2【刊名】中國組織工程研究與臨床康復(fù).2010,14(47

7、).-8791-8794【文摘】背景：-己內(nèi)酯與L-丙交酯共聚物具有良好的力學(xué)性能,并且降解速率可調(diào)范圍大,作為組織工程人工血管材料方面受到人們的青睞。目的：了解-己內(nèi)酯與L-丙交酯共聚物（PCLA）的降解性能及生物相容性。方法：通過調(diào)節(jié)單體的投料比制備不同組成、不同相對分子質(zhì)量的-己內(nèi)酯/L-丙交酯共聚物,以脂肪酶溶液作為降解液研究共聚物的降解性能;并且通過體內(nèi)種植實(shí)驗(yàn)研究其生物相容性。結(jié)果與結(jié)論：-己內(nèi)酯與L-丙交酯投料摩爾比為75/25的-己內(nèi)酯與L-丙交酯共聚物在降解過程中保持著較高的力學(xué)性能;并且組織相容性好,可用于制備組織工程人工血管。檢索式：M=生物材料*降解*U =體外檢索結(jié)果

8、：6/40【題名】聚碳酸酯型聚氨酯的生物降解性【作者】庹新林1 夏維娟1 程曉非2 吳繼功2 鄒德威2【刊名】中國組織工程研究與臨床康復(fù).2010,14(47).-8831-8834【文摘】背景：不同聚氨酯材料的生物穩(wěn)定性差異巨大,研究聚碳酸酯型聚氨酯的生物穩(wěn)定性有利于評估其用于人工髓核外囊材料的可行性。目的：觀察聚醚型聚氨酯和具有不同硬段含量的聚碳酸酯型聚氨酯材料的體外和體內(nèi)降解性能。方法：用模擬環(huán)境進(jìn)行聚氨酯的體外水解、氧化降解和酶解實(shí)驗(yàn)。分別置于37恒溫的PBS緩沖液和H2O2/CoCl2預(yù)氧化-Papain酶解體系進(jìn)行體外降解實(shí)驗(yàn)。將聚氨酯植入大耳白兔背部肌肉進(jìn)行體內(nèi)降解實(shí)驗(yàn)。結(jié)果與結(jié)

9、論：聚碳酸酯型聚氨酯耐降解性遠(yuǎn)優(yōu)于聚醚型聚氨酯,且材料硬段含量越大,耐降解性越強(qiáng)。所有研究結(jié)果表明聚碳酸酯型聚氨酯具有比聚醚型聚氨酯更加優(yōu)越的生物穩(wěn)定性,可用作較長期人工植入生物材料。7/40【題名】軟骨組織工程研究進(jìn)展【作者】姜疆（綜述）1 孫楊（綜述）2 郭樹忠（審校）1【刊名】中國美容醫(yī)學(xué).2010,19(4).-611-614【文摘】軟骨組織工程的基本原理是從機(jī)體獲取少量活組織,將功能細(xì)胞從組織中分離出來,并在體外進(jìn)行培養(yǎng)、擴(kuò)增,然后與可降解吸收的支架材料按一定比例混合,植入病損部位,生物材料在體內(nèi)逐漸降解和吸收,植入細(xì)胞在體內(nèi)增殖和分泌ECM,最后形成所需的組織或器官,8/40【題名

10、】生物降解材料對成骨細(xì)胞影響的研究進(jìn)展【作者】陳太勇 李開南【刊名】現(xiàn)代臨床醫(yī)學(xué).2009,35(6).-409-411【文摘】生物降解材料是指植入人體以后，能夠不斷發(fā)生降解，降解產(chǎn)物能夠被生物體所吸收或排出體外的一類材料。隨著醫(yī)學(xué)以及材料學(xué)的發(fā)展，尤其是新型材料的研究開發(fā)成功，如20世紀(jì)40年代高分子材料的大力發(fā)展，為生物材料的研究與應(yīng)用提供了極大的發(fā)展機(jī)會(huì)。，目前骨科常用的生物降解材料主要包括天然高分子材料、9/40【題名】聚乳酸硅灰石生物醫(yī)用復(fù)合材料的降解性能【作者】徐梁1 熊成東2【刊名】重慶工學(xué)院學(xué)報(bào)：自然科學(xué)版.2009,23(3).-69-75【文摘】對聚乳酸硅灰石這種新型的生物

11、醫(yī)用復(fù)合材料進(jìn)行了研究。采用溶劑共沉淀法制備含不同質(zhì)量分?jǐn)?shù)硅灰石（5，10，20和30）的復(fù)合物材料并模壓成型，測定其力學(xué)性能，包括拉伸強(qiáng)度和彎曲強(qiáng)度。結(jié)果表明，在聚乳酸基體中加入硅灰石，其力學(xué)性能有所下降，僅當(dāng)硅灰石質(zhì)量分?jǐn)?shù)為10時(shí)，拉伸強(qiáng)度略高于純聚乳酸材料。選取含硅灰石10的復(fù)合材料放人37.5恒溫模擬體液中浸泡1，2，4，6，8，11，14，17，20，24及28周，考察其體外降解性能，包括質(zhì)量損失、體系pH值變化及力學(xué)強(qiáng)度的變化。在降解過程中，聚乳酸硅灰石復(fù)合材料降解速度較慢，并且保持相對較好的力學(xué)性能，適于應(yīng)用在骨修復(fù)及骨組織工程領(lǐng)域。10/40【題名】PBTEOLA共聚酯體內(nèi)外降

12、解及組織相容性【作者】崔蘇萍1 王英磊1 陳義旺2 汪泱1 謝安婁1 遠(yuǎn)蕾1 朱祥軍2【刊名】江西醫(yī)藥.2009,44(2).-109-113【文摘】目的探討國產(chǎn)生物降解泌尿系支架材料（對苯二甲酸丁二醇酯-co-聚乙二醇-co-低聚乳酸）三元共聚酯（PBTEOLA）的組織相容性及體內(nèi)、體外降解特性。方法將PBTEOLA試件埋植在SD大鼠脊柱兩側(cè)皮下組織內(nèi)或浸泡于磷酸鹽緩沖液中，分別于2、4、6、8、10、12、14及16周取出通過組織病理學(xué)切片研究材料周圍組織反應(yīng)，利用掃描啦譴檢夏材料的表面征象，準(zhǔn)確稱重以檢測材料降解前后的重量。以了解PBTEOLA在體內(nèi)、體外的降解情況和組織相容性。結(jié)果PB

13、TEOLA材料在16周內(nèi)可降解為細(xì)小顆粒材料的體內(nèi)、體外降解趨勢相同，體內(nèi)降解速度略快于體外降解。埋植材料周圍皮下組織無膿腫形成和組織壞死發(fā)生，局部組織反也為輕微的炎癥反應(yīng)。結(jié)論P(yáng)BTEOLA材料組織相容性良好，降解時(shí)間適宜，適用于制備泌尿系支架，可進(jìn)一步研究開發(fā)。二、中國期刊全文數(shù)據(jù)庫檢索檢索式：篇名生物+材料+降解 并且 主題生物+材料+降解 并且 摘要天然+生物+材料+降解檢索結(jié)果：11/40題名 天然纖維/可降解塑料生物復(fù)合材料研究 作者 王云飛;商偉輝;郭云竹;張淑萍; 中文摘要 本文闡述可完全降解的生物質(zhì)纖維復(fù)合材料的概念,介紹天然纖維/可生物降解塑料復(fù)合材料的制造工藝,研究了原材

14、料天然纖維和可生物降解塑料的性能及其復(fù)合材料的性能。 刊名 纖維復(fù)合材料 年 2010 期 04 12/40題名 生物降解高分子材料研究進(jìn)展 作者 郝明鳳;劉勇;丁玉梅;楊衛(wèi)民; 中文摘要 介紹了生物降解高分子材料的概念和分類,并結(jié)合具體實(shí)例詳細(xì)論述了目前國內(nèi)外在天然、微生物合成、化學(xué)合成和摻混型等四類生物降解高分子材料方面的研究方向及最新研究進(jìn)展。 刊名 工程塑料應(yīng)用 年 2010 期 02 13/40題名 天然植物纖維/可生物降解塑料生物質(zhì)復(fù)合材料研究現(xiàn)狀與發(fā)展趨勢 作者 郭文靜;王正;鮑甫成;常亮; 中文摘要 由天然植物纖維材料與可生物降解塑料復(fù)合制備生物質(zhì)復(fù)合材料是本世紀(jì)新的研究熱點(diǎn),

15、也是復(fù)合材料科學(xué)發(fā)展的必然趨勢并具有非常廣闊應(yīng)用前景的完全環(huán)境友好新材料。本文從復(fù)合材料的原材料、復(fù)合途徑、復(fù)合材料性能改善及復(fù)合機(jī)制等方面論述天然植物纖維/可生物降解生物質(zhì)復(fù)合材料的研究現(xiàn)狀,并就生物質(zhì)復(fù)合材料的發(fā)展趨勢與前景進(jìn)行分析。 刊名 林業(yè)科學(xué) 年 2008 期 01 14/40題名 基于天然植物資源的可生物降解聚氨酯材料的制備進(jìn)展 作者 閆莉;王曉輝;姚成; 中文摘要 綜述了近年來以天然植物資源為原料制備可生物降解聚氨酯材料的國內(nèi)外研究進(jìn)展;指出利用樹皮、甘蔗渣、玉米棒、植物秸稈等天然植物原料液化多元醇制備可生物降解聚氨酯材料,具有廣闊的開發(fā)前景。 刊名 現(xiàn)代化工 年 2007 期

16、 S2 15/40題名 天然生物可降解材料在生物醫(yī)學(xué)領(lǐng)域中的應(yīng)用 作者 顧偉;劉雷艮;左保齊; 中文摘要 天然生物可降解材料具有優(yōu)良的生物相容性,良好的生物力學(xué)功能、物理化學(xué)性能、生物性能,且原料來源廣泛,目前在生物醫(yī)學(xué)領(lǐng)域得到了廣泛應(yīng)用。本文就應(yīng)用最廣的絲素、膠原和殼聚糖與甲殼質(zhì)等幾種主要的可生物降解材料在醫(yī)學(xué)上的用途作一綜述。 刊名 蘇州大學(xué)學(xué)報(bào)(工科版) 年 2006 期 01 檢索式： 主題生物材料并且 關(guān)鍵詞體外 并且 降解 并且 篇名研究檢索結(jié)果：16/40題名 生物降解微球制劑的體內(nèi)外相關(guān)性研究進(jìn)展 作者 李靜;蘇慶;趙剛; 中文關(guān)鍵詞 中文摘要 <正>可生物降解注射

17、用微球是近年來發(fā)展較快的一種新劑型,它是指利用天然或合成的高分子材料,將固體或液體藥物包嵌成直徑為1250m的微小球體。該制劑技術(shù)將蛋白和多肽等類藥物制備成以微球?yàn)檩d體的長效緩控釋制劑。 刊名 中國醫(yī)藥生物技術(shù) 年 2011 期 01 17/40題名 生物降解性合成高分子材料作為藥物緩釋載體的研究進(jìn)展 作者 楊立群;楊丹;孟舒;關(guān)艷敏;李建新;李淼; 中文關(guān)鍵詞 生物降解性高分子;合成高分子;藥物載體;藥物緩釋體系 中文摘要 生物降解性合成高分子材料安全、可靠,有良好的生物相容性,成為藥物緩釋載體的首選材料。本文簡要綜述了主要常用的生物降解性合成高分子材料作為藥物緩釋載體的研究進(jìn)展,并對其發(fā)展

18、趨勢進(jìn)行了展望。 刊名 當(dāng)代醫(yī)學(xué) 年 2009 期 3318/40題名 體外研究聚合物P(DLLA-co-TMC)的降解性能與釋藥行為 作者 楊丹;楊立群;關(guān)艷敏;李淼;李建新; 中文關(guān)鍵詞 生物相容性材料;藥物釋放系統(tǒng);孕二烯酮 中文摘要 目的研究P(DLLA-co-TMC)聚合物的體外降解性能與釋藥行為,且探討該聚合物作為長效避孕釋放載體的可行性。方法以PBS溶液為溶媒研究P(DLLA-co-TMC)的降解性能;以P(DLLA-co-TMC)聚合物為載體制備含孕二烯酮的載藥片,并通過蒸餾水浸泡載藥片研究載藥體系的體外釋藥行為。結(jié)果P(DLLA-co-TMC)聚合物前期降解較慢,第30天和第

19、90天失重率分別為10.0%和12.3%,后期降解速率較快,第120天的失重率為59.3%;P(DLLA-co-TMC)的載藥片前期釋藥速率較大,出現(xiàn)"暴釋現(xiàn)象",后期釋藥速率減緩并逐漸趨于平穩(wěn),第100天時(shí)累計(jì)釋放率為5.64%。結(jié)論P(yáng)(DLLA-co-TMC)聚合物降解性能良好、釋藥效果明顯,有望通過體內(nèi)研究使含孕二烯酮的P(DLLA-co-TMC)聚合物載藥系統(tǒng)應(yīng)用于長效埋植避孕。 刊名 中國醫(yī)藥生物技術(shù) 年 2009 期 04 19/40題名 聚富馬酸丙二醇酯/(硫酸鈣/-磷酸三鈣)生物復(fù)合材料的體外降解研究 作者 邸利芝;劉斌;羅躍娥;趙紅;蔡仲雨; 中文關(guān)鍵詞

20、聚富馬酸丙二醇酯;硫酸鈣/-磷酸三鈣;原位成孔;體外降解 中文摘要 研究了聚富馬酸丙二醇酯/(硫酸鈣/-磷酸三鈣)(PPF/(CaSO4/-TCP)生物復(fù)合材料降解過程中,PPF分子量、N-乙烯基吡咯烷酮(NVP)與PPF比例和CaSO4與-TCP摩爾比對復(fù)合材料失重、吸水率、溶脹度、抗壓強(qiáng)度和模量的影響.復(fù)合材料的失重、吸水率和溶脹度隨著PPF分子量的增加或NVP/PPF比例、CaSO4/-TCP摩爾比的降低而降低.降解前后的壓縮強(qiáng)度和壓縮模量隨著NVP/PPF比例和CaSO4/-TCP摩爾比的降低而升高.降解42 d后,最大失重、吸水率和溶脹度分別達(dá)14.7%、57.0%和36.3%;通過

21、42 d的降解,所有試樣的抗壓模量在57.0712 MPa,最大抗壓強(qiáng)度在3.120.6 MPa,屈服強(qiáng)度在0.1534.0 MPa.通過SEM分析,觀察到了PPF/(CaSO4/-TCP)復(fù)合材料的原位成孔現(xiàn)象. 刊名 天津理工大學(xué)學(xué)報(bào) 年 2009 期 03 20/40題名 生物可降解聚丁二酸乙二醇酯的合成與降解性能研究 作者 劉偉;石峰暉;季君暉;王進(jìn)鋒;李煥新; 中文關(guān)鍵詞 聚丁二酸乙二醇酯;熔融聚合;生物降解;體外降解 中文摘要 以丁二酸和乙二醇為原料,直接熔融聚合,合成了高相對分子量的聚丁二酸乙二醇酯(PES),用FTIR,1H-NMR表征其結(jié)構(gòu);考察了不同聚酯反應(yīng)催化劑對其聚合反

22、應(yīng)的影響,結(jié)果表明:三氧化二銻的催化效果是最佳的。同時(shí),利用酶降解和體外水解的方法,對聚合物降解性能進(jìn)行研究,結(jié)果表明:PES是一種可生物降解的聚合物,且在體外具有一定的降解性。 刊名 塑料 年 2008 期 04 三、SCI數(shù)據(jù)庫檢索檢索式：主題=(biological)AND標(biāo)題=（material*）AND標(biāo)題=（degradation）檢索結(jié)果：21/40AU Su, WWang, HFFeng, JLuo, XHZhang, XZZhuo, RX AF Su, WeiWang, Hua-fenFeng, JunLuo, Xiao-huaZhang,Xian-zhengZhuo, Re

23、n-xiTI Novel cationic poly(ester-co-carbonate) materials functionalized with tertiary amine groups 新型陽離子聚（酯聯(lián)合碳酸鹽）材料的叔胺官功能SO JOURNAL OF MATERIALS CHEMISTRY AB The current study aimed at designing cationic and biodegradable biomaterials with improved biological functionality. We report the enzymatic s

24、ynthesis, characterization and preliminary biological assessment of a series of novel functionalized poly(ester-co-carbonate)s, namely poly(ADMC-co-CL)s containing tertiary amine groups in the backbone. The copolymer compositions agreed very well with the feed ratios of co-monomers, indicating the e

25、xcellent controllability of the preparation method. Static contact angle measurement revealed that the hydrophilicity of copolymers can be tailored and gradually increased with an increasing ADMC content in copolymers. With respect to the weight loss, in vitro degradation tests demonstrated the occu

26、rrence of lipase-dependent degradation. Copolymers with a higher ADMC content degraded far faster as well. Cell proliferation tests suggested that the incorporation of ADMC in copolymers would considerably promote cell adhesion and proliferation on the polymer surface, indicative of good biocompatib

27、ility. As a demonstration of a potential application, poly(ADMC-co-CL) microspheres were fabricated in an attempt to construct a controlled delivery system for the drug ibuprofen. The sustained release of ibuprofen loaded in the copolymers was found to have an evident acceleration in acidic conditio

28、ns, indicating the pH dependence of such release behavior. SN 0959-9428 PY 2011 VL 21 IS 17 DI 10.1039/c0jm04245e UT ISI:000289524300032 22/40AUArwin, HAFArwin, HansTI Application of ellipsometry techniques to biological materials橢偏技術(shù)的應(yīng)用生物材料SO THIN SOLID FILMS AB Ellipsometry is well-suited for bioa

29、dsorption studies and numerous reports, mainly using null ellipsometry, are found on this subject whereas investigations addressing structural properties of thin biolayers are few. Here two examples based on the use of spectroscopic ellipsometry (SE) on the latter are briefly discussed. In the first

30、 example, time evolution of thickness, spectral refractive index and surface mass density of a fibrinogen matrix forming on a silicon substrate are investigated with SE and a structural model of the protein matrix is discussed. In the second example a model dielectric function concept for protein mo

31、nolayers is presented. The model allows parameterization of the optical properties which facilitates monitoring of temperature induced degradation of a protein layer. More recently, photonic structures in beetles have been studied with SE. It is shown here that full Mueller-matrix SE can resolve ver

32、y complex nanostructures in scarab beetles, more specifically chiral structures causing reflected light to become circularly polarized. (C) 2010 Elsevier B.V. All rights reserved. SN 0040-6090 PD FEB 28 PY 2011 DI 10.1016/j.tsf.2010.11.082 UT ISI:000289174200005 23/40AUSorkhoh, NAAl-Awadhi, HAl-Mail

33、em, DMKansour, MKKhanafer, MRadwan, SS AFSorkhoh, N. A.Al-Awadhi, H.Al-Mailem, D. M.Kansour, M. K.Khanafer, M.Radwan, S. S. TI Agarolytic bacteria with hydrocarbon-utilization potential in fouling material from the Arabian Gulf coast Agarolytic細(xì)菌對阿拉伯海灣沿岸污染物質(zhì)的潛在利用SO INTERNATIONAL BIODETERIORATION &am

34、p; BIODEGRADATION AB Fouling material adhering to a neglected navigation vehicle half-sinking in the coastal water of the Arabian Gulf harbored two agarolytic bacterial species Halomonas aquamarina and Alteromonas macleodu with hydrocarbon-utilization potential Both species were halophilic (optimum

35、2-5% NaCl w/v) slightly alkaliphilic (optimum pH 8) and grew best at 25 degrees C The oil and hydrocarbon consumption potential of both species was dramatically enhanced (2 fold or more) by the addition of agar powder to the liquid medium Both organisms were able to grow on a nitrogen free medium Th

36、ese results imply that such agarolytic bacteria could potentially be suitable biological systems for self-cleaning and bioremediation of oily marine ecosystems (C) 2010 Published by Elsevier Ltd SN 0964-8305 PD OCT PY 2010 DI 10.1016/j.ibiod.2010.06.007 UT ISI:000283968700003 檢索式：主題=(biological*)AND

37、標(biāo)題=（material*）AND標(biāo)題=（degradation）檢索結(jié)果：24/40AU Vavilin, VAFernandez, BPalatsi, JFlotats, X TI Hydrolysis kinetics in anaerobic degradation of particulate organic material: An overview 有機(jī)微粒材料的厭氧降解的動(dòng)力學(xué)水解概述SO WASTE MANAGEMENT AB The applicability of different kinetics to the hydrolysis of particulate or

38、ganic material in anaerobic digestion is discussed. Hydrolysis has traditionally been modelled according to the first-order kinetics. For complex substrate, the first-order kinetics should be modified in order to take into account hardly degradable material. It has been shown that models in which hy

39、drolysis is coupled to the growth of hydrolytic bacteria work well at high or at fluctuant organic loading. In particular, the surface-related two-phase and the Contois models showed good fits to experimental data from a wide range of organic waste. Both models tend to the first-order kinetics at a

40、high biomass-to-waste ratio and, for this reason, they can be considered as more general models. Examples on different inhibition processes that might affect the degradation of solid waste are reported. Acetogenesis or methanogenesis might be the rate-limiting stages in complex waste. In such cases,

41、 stimulation of hydrolysis (mechanically, chemically or biologically) may lead to a further inhibition of these stages, which ultimately affects hydrolysis as well. Since the hydrolysis process is characterized by surface and transport phenomena, new developments in spatially distributed models are

42、considered fundamental to provide new insights in this complex process. (C) 2007 Elsevier Ltd. All rights reserved. SN 0956-053X PY 2008 DI 10.1016/j.wasman.2007.03.028 UT ISI:000255467600002 -25/40AURadin, SFalaize, SLee, MHDucheyne, PTI Application of ellipsometry techniques to biological material

43、s 二氧化硅干凝行為作為控釋材料在體外的生物活性和降解表現(xiàn)SO BIOMATERIALS AB Room temperature-processed silica-based sol-gel, termed silica xerogel, is a novel type of controlled release material. As shown previously, these materials are porous, degradable and can release biologically functional molecules in a controlled manner

44、. It was also demonstrated that these materials are biocompatible in vivo. Herein we report on the ability of silica-based xerogels to form a bioactive. apatite-like (AP) surface and the effect of AP surface on the xerogel stability in vitro. Formation of a crystalline, carbonated AP (c-AP) was foun

45、d on all silica xerogels studied, with or without Ca- and P-oxides. Calcium and phosphate (Ca-P) free xerogels showed long times to Ca-P precipitation and to formation of a detectable AP-layer (LIP to 2 weeks). In contrast, the times to precipitation were reduced by 2-3 orders of magnitude, and the

46、c-AP layer was formed within 24 h on all Ca-P containing xerogels. Mechanisms of the c-AP formation on these xerogels were similar to those typical for Ca-P based ceramics: dissolution of calcium and phosphate ions, Solution oversaturation with respect to AP and Subsequent precipitation of bone-like

47、 minerals. The presence of the c-AP surface film produced a remarkable surface stabilizing effect: the rates and the amounts of Si release were significantly reduced in comparison to those for xerogels without the film. This evidence of in vitro bioactivity and controlled degradation, combined with

48、previous in vitro and in vivo reports, suggests that silica xerogel is a promising controlled release material. (C) 2002 Elsevier Science Ltd. All rights reserved. SN 0142-9612 PD AUG PY 2002 四、EI數(shù)據(jù)庫檢索檢索式：（biological materials）WN KY）AND(degradat*)WN KY)）AND(research)WN KY)）檢索結(jié)果：26/40Research on rheo

49、logical and thermal properties of P(3HB-4HB)/PEG and the preparation for fiber關(guān)于P（3HB - 4HB）/聚乙二醇的流變學(xué)性質(zhì)和熱學(xué)性質(zhì)與制備纖維束的研究Guo, Jing1; Zheng, Nan1; Zhang, Sen2 Source: Advanced Materials Research, v 152-153, p 1611-1615, 2011, New Materials and Advanced Materials; Conference: 2010 International Conference

50、 on Advances in Materials and Manufacturing Processes, ICAMMP 2010, November 6, 2010 - November 8, 2010; Sponsor: University of Wollongong (UOW); Northeastern University (NU); University of Science and Technology Beijing (USTB); Hebei Polytechnic University (HPU); Hong Kong Industrial Technology Res

51、earch Centre (ITRC); Publisher: Trans Tech PublicationsAbstract: 3-hydroxybutyrate-co-4-hydroxybutyrate P(3HB-4HB) is one of polyhydroxyalkanoates which is biodegradable and biocompatible, and is one of the hot issues of the biodegradable materials research. But the degradation will occur at high te

52、mperature and shear rate. So P(3HB-4HB) is modified with PEG10000 by means of a mechanical blending. In this research, capillary rheometer and TGA are applied to investigate its rheological and thermal behaviors. The technology of melt spinning is also studied and the P(3HB-4HB)/PEG10000 fiber with

53、a certain mechanical property is obtained successfully. Electronic velocimeter and electronic single end yarn strength tester are applied to investigate the mechanical property of the fiber. The result of TG indicates that the addition of PEG10000 improves the thermal stability of P(3HB-4HB). The re

54、sult of capillary rheometer shows that P(3HB-4HB)/PEG10000 is pseudoplasticfluid. Because of the addition of PEG10000, the non-Newtonian index n of the P(3HB-4HB)/PEG10000 sample increases and the flow activation energy of the P(3HB-4HB)/PEG10000 sample decreases. The result of fiber strength test s

55、hows that the addition of PEG10000 has an impact on the mechanical property of the fiber and the lowest fiber strength appeared when PEG10000 content was P(3HB-4HB)/PEG=100/6. The moisture regain ratio increases with the content of PEG10000 rising. And when PEG10000 content is P(3HB-4HB)/PEG=100/2,

56、the highest degree of orientation of fiber appears. © (2011) Trans Tech Publications, Switzerland. (4 refs.)27/40Ex vivo and in vitro synchrotron-based micro-imaging of biocompatible materials applied in dental surgery在體內(nèi)和體外同步為基礎(chǔ)的微型牙科手術(shù)中的應(yīng)用生物相容性材料成像Rack, A.1; Stiller, M.2; Nelson, K.2; Knabe, C

57、.2; Rack, T.2; Zabler, S.3; Dalügge, O.2; Riesemeier, H.4; Cecilia, A.5; Goebbels, J.4 Source: Proceedings of SPIE - The International Society for Optical Engineering, v 7804, 2010, Developments in X-Ray Tomography VII; ISSN: 0277786X; ISBN-13: 9780819483003; DOI: 10.1117/12.858435; Article number: 780