微珠圖案上有序排列的孔的多孔膜

1、Microbead Patterning on Porous Film with Ordered Arrays of Pores Reporter: Lei Zhang Lei Liu Jianheng LiOutlinelSome conventional researches lA novel method based on evaporative cooling and subsequent water-droplet templatinglApplicationTemplating methods based on self-assembly techniqueslSelf-assem

2、bly of colloidal microspheres on a solid substrate to form a 2D crystalline structure as a templatelInfusion of other materials in to the voids of the self-assembled microspheres solidification of the materiallRemoval of the template microspheresProblemslDifficult to self-assemble template microsphe

3、res with long-range orderlUnstablelEasily damaged during the removal the templateThe Flow Chart of the New MethodlOptical images of polystyrene/ silica films with ordered arrays of pores:la) low resolutionlb) high resolution SEM images with different pore sizes How to control pore sizeslThe amount o

4、f TEOSlPolystyrene bead sizeslThe amount of the solution added onto the surface of the substrateHow to control pore sizeslThe relationships between the pore size, polystyrene bead size and amount of TEOS added. Patterning of PS Microbeads on the Porous FilmslA suspension of polystyrene microbeads wa

5、s dropped onto the porous film, fully covering the top surface of the film. lThe film was then shaken on a shaker to allow as many beads to go into the pores as possible. lThe surface of the film was then washed with water to remove the excess beads. lThe excess solution was then allowed to evaporat

6、e at room temperature.The size influence in patterning the microbeadslWhen the size of the microbeads is bigger than that of the pores, the microbeads sit on the pores rather than entering themlWhen the size of the microbeads is similar to, or a bit smaller than, that of the pores the microbeads can

7、 enter the poresla,b) Optical and fluorescence images showing the patterning of fluorescent polystyrene microbeads on the porous film.ConclusionlIt is a nonlithographic breath-figure methodlIt can be achieved on the polymer filmslThe size of the pores can be readily controlled by controlling the syn

8、thetic conditionsApplicationlThis method has the potential to be used in bead-based multiplexed detection and sensing applications.lPatterning of protein-immobilized polystyrene microbeads on the film was conducted using fluorescein isothiocyanate-conjugated bovine serum albumin (FITC-BSA)ReferencelB. Franois, O. Pitois, J. Franois, Adv. Mater. 1995, 7, 1041.lJ. Peng, Y. C. Han, Y. M. Yang, B. Y. Li, Polymer 2004, 45, 447.lG. Widawski, M. Rawiso, B.