Bacterial-Inhibitors-Modulators-MCE

1、 HYPERLINK https:/www.MedChemE/Targets/Bacterial.html BacterialAnything that destroys bacteria or suppresses their growth or their ability to reproduce. Heat, chemicals such as chlorine, andantibiotic drugs all have antibacterial properties. Many antibacterial products for cleaning and handwashing a

2、re sold today. Suchproducts do not reduce the risk for symptoms of viral infectious diseases in otherwise healthy persons. This does not preclude thepotential contribution of antibacterial products to reducing symptoms of bacterial diseases in the home.www.MedChemE 1 HYPERLINK https:/www.MedChemE/Ta

3、rgets/Bacterial.html Bacterial HYPERLINK https:/www.MedChemE/Targets/Bacterial.html HYPERLINK https:/www.MedChemE/Targets/Bacterial.html Inhibitors, HYPERLINK https:/www.MedChemE/Targets/Bacterial.html HYPERLINK https:/www.MedChemE/Targets/Bacterial.html Agonists, HYPERLINK https:/www.MedChemE/Targe

4、ts/Bacterial.html HYPERLINK https:/www.MedChemE/Targets/Bacterial.html Antagonists, HYPERLINK https:/www.MedChemE/Targets/Bacterial.html HYPERLINK https:/www.MedChemE/Targets/Bacterial.html Activators, HYPERLINK https:/www.MedChemE/Targets/Bacterial.html HYPERLINK https:/www.MedChemE/Targets/Bacteri

5、al.html Modulators, HYPERLINK https:/www.MedChemE/Targets/Bacterial.html HYPERLINK https:/www.MedChemE/Targets/Bacterial.html Chemicals HYPERLINK https:/www.MedChemE/Targets/Bacterial.html HYPERLINK https:/www.MedChemE/Targets/Bacterial.html & HYPERLINK https:/www.MedChemE/Targets/Bacterial.html HYP

6、ERLINK https:/www.MedChemE/Targets/Bacterial.html Inducers HYPERLINK https:/www.MedChemE/3r-8s-falcarindiol.html (+)-(3R,8S)-Falcarindiol(3R,8S)-Falcarindiol; 3(R),8(S),9(Z)-Falcarindiol) Cat. No.: HY-N1976 HYPERLINK https:/www.MedChemE/_addition_-Camphor.html (+)-Camphor(D-(+)-Camphor; (1R)-(+)-Cam

7、phor) Cat. No.: HY-B1173(+)-(3R,8S)-Falcarindiol is a polyacetylene foundin carrots, has antimycobacterial activity,with an IC of 6 M and MIC of 24 M against50Mycobacterium tuberculosis H37Ra. Antineoplasticand anti-inflammatory activity.(+)-Camphor is an ingredient in cooking, and as anembalming fl

8、uid for medicinal purposes,.Purity: 99.88%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mgPurity: 98.0%Clinical Data: LaunchedSize: 10 mM 1 mL, 500 mg HYPERLINK https:/www.MedChemE/plus-medioresinol.html (+)-Medioresinol HYPERLINK https:/www.MedChemE/plus-medioresinol.html HYPERLINK htt

9、ps:/www.MedChemE/usnic-acid.html (+)-Usnic HYPERLINK https:/www.MedChemE/usnic-acid.html HYPERLINK https:/www.MedChemE/usnic-acid.html acidCat. No.: HY-N3307 Cat. No.: HY-N0656A(+)-Medioresinol is a furofuran type lignan withantifungal, antibacterial and lesishmanicidalactivities. (+)-Medioresinol l

10、eads tointracellular ROS accumulation andmitochondria-mediated apoptotic cell death inCandida albicans.(+)-Usnic acid is isolated from isolated fromlichens, binds at the ATP-binding pocket ofmTOR, and inhibits mTORC1/2 activity.Purity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 m

11、gPurity: 99.0%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 100 mg HYPERLINK https:/www.MedChemE/_addition_-Viroallosecurinine.html (+)-ViroallosecurinineCat. No.: HY-N5002 HYPERLINK https:/www.MedChemE/minus-cedrene.html (-)-Cedrene(-cedrene) Cat. No.: HY-135190(+)-Viroallosecurinine, a c

12、ytotoxic alkaloid,exhibits a MIC of 0.48 g/mL for Ps. Aeruginosa andStaph. aureus. Antibacterial activity.(-)-Cedrene (-cedrene) is a sesquiterpeneconstituent of cedarwood oils, with anti-leukemic,antimicrobial and anti-obesity activities.Purity: 98%Clinical Data: No Development ReportedSize: 5 mg,

13、10 mg, 25 mgPurity: 98.0%Clinical Data: No Development ReportedSize: 1 mL, 5 mL HYPERLINK https:/www.MedChemE/corynoxidine.html (-)-Corynoxidine HYPERLINK https:/www.MedChemE/corynoxidine.html HYPERLINK https:/www.MedChemE/minus-corypalmine.html (-)-CorypalmineCat. No.: HY-N7010(Discretinine) Cat. N

14、o.: HY-N3636(-)-Corynoxidine is an acetylcholinesteraseinhibitor with an IC value of 89.0 M, isolated50from the aerial parts of Corydalis speciosa.(-)-Corynoxidine exhibits antibacterial activitiesagainst Staphylococcus aureus andmethicillin-resistant S.(-)-Corypalmine (Discretinine), an alkaloid th

15、atcould be isolated from the stem of Guatteriopsisfriesiana, possesses antimicrobialactivity.Purity: 98%Clinical Data: No Development ReportedSize: 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg HYPERLINK https:/www.MedChemE/alpha-pinene.html (-)-Pinene HYPERLINK https

16、:/www.MedChemE/alpha-pinene.html HYPERLINK https:/www.MedChemE/1r-pinene.html (1R)-PineneCat. No.: HY-N0549 Cat. No.: HY-Y0739(-)-Pinene is a monoterpene and shows sleepenhancing property through a direct binding toGABAA-benzodiazepine (BZD) receptors by acting asa partial modulator at the BZD bindi

17、ng site.(1R)-Pinene is a volatile monoterpene withantimicrobial activities. (1R)-Pinene reducesBacillus cereus population growth, and exhibitsrepellent effects.Purity: 99.63%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 100 mg, 1 g, 5 gPurity: 98.16%Clinical Data: No Development ReportedSi

18、ze: 1 g2 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/20r-protopanaxadiol.html (20R)-Protopanaxadiol HYPERLINK https:/www.MedChemE/20r-protopanaxadiol.html HYPERLINK https:/www.MedChemE/3r-7-4-dihydrohomoisoflavanone.html (3R)-7,4-DihydrohomoisoflavanoneCat.

19、 No.: HY-N2040 Cat. No.: HY-N8186(20R)-Protopanaxadiol is a triterpenoid saponinmetabolite of 20(R)-ginsenoside Rg3 in blackginseng. (20R)-Protopanaxadiol exhibits anti-tumoractivity and cytotoxicity, and potently inhibitsthe growth of Helicobacter pylori.(3R)-7,4-Dihydrohomoisoflavanone is a natura

20、lproduct with antibacterial activities against S.aureus and methicillin-resistant Staphylococcusaureus (MRSA).Purity: 98.0%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mgPurity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg HYPERLINK https:/www.MedChemE/3r-4r-

21、a2-32-01.html (3R,4R)-A2-32-01 HYPERLINK https:/www.MedChemE/3r-4r-a2-32-01.html HYPERLINK https:/www.MedChemE/5-stigmastane-3-6-dione.html (5)-Stigmastane-3,6-dioneCat. No.: HY-111532 Cat. No.: HY-N1203(3R,4R)-A2-32-01 (compound 2), an anti-virulencedrug, is a specific caseinolytic protein protease

22、s(ClpP) inhibitor with an EC of 4.5 M, and50shows a tolerable cytotoxicity.(5)-Stigmastane-3,6-dione is a naturallyoccurring sterol that could be isolated fromfruits of Ailanthus altissima Swingle.Antimicrobial Activity.Purity: 99.28%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 m

23、g, 50 mg, 100 mgPurity: 96.0%Clinical Data: No Development ReportedSize: 5 mg HYPERLINK https:/www.MedChemE/8-9-dihydroxy-3-farnesylindole.html (8,9-Dihydroxy)-3-farnesylindoleCat. No.: HY-N10128 HYPERLINK https:/www.MedChemE/e-methyl-4-coumarate.html (E)-Methyl HYPERLINK https:/www.MedChemE/e-methy

24、l-4-coumarate.html HYPERLINK https:/www.MedChemE/e-methyl-4-coumarate.html 4-coumarate(Methyl trans-p-coumarate) Cat. No.: HY-N2492(8,9-Dihydroxy)-3-farnesylindole shows stronginhibitory activity (EC50 9.8 M) against B.subtilis.(E)-Methyl 4-coumarate (Methyl4-hydroxycinnamate), found in several plan

25、ts, suchas green onion (Allium cepa) or noni (Morindacitrifolia L.) leaves.Purity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mgPurity: 99.83%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 100 mg HYPERLINK https:/www.MedChemE/r-eucomol.html (R)-Eucomol HYPERLINK https:/w

26、ww.MedChemE/r-eucomol.html HYPERLINK https:/www.MedChemE/r-fangchinoline.html (R)-FangchinolineCat. No.: HY-N7321A(Thalrugosine; Thaligine) Cat. No.: HY-N1372(R)-Eucomol, a flavonoid derivative, displaysmarginal antibacterial activity. (R)-Eucomol showscytotoxic activity against KB and P-388 cells.(

27、R)-Fangchinoline (Thalrugosine), a alkaloids fromgenus Stephaniaexhibits antimicrobial andhypotensive activity.Purity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mgPurity: 99.83%Clinical Data: No Development ReportedSize: 5 mg, 10 mg HYPERLINK https:/www.MedChemE/_R_-Ofloxacin.ht

28、ml (R)-Ofloxacin HYPERLINK https:/www.MedChemE/_R_-Ofloxacin.html HYPERLINK https:/www.MedChemE/r-ofloxacin-d3.html (R)-Ofloxacin-d3(Dextrofloxacin) Cat. No.: HY-B0330DCat. No.: HY-B0330DS(R)-Ofloxacin (Dextrofloxacin) is an antibioticuseful for the treatment of a number of bacterialinfections. Anti

29、bacterial activity.(R)-Ofloxacin-d3 is the deuterium labeled(R)-Ofloxacin. (R)-Ofloxacin (Dextrofloxacin) isan antibiotic useful for the treatment of a numberof bacterial infections. Antibacterial activity.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No

30、Development ReportedSize: 2.5 mg, 25 mgwww.MedChemE 3 HYPERLINK https:/www.MedChemE/r-r-bay-y-3118.html (R,R)-BAY-Y HYPERLINK https:/www.MedChemE/r-r-bay-y-3118.html HYPERLINK https:/www.MedChemE/r-r-bay-y-3118.html 3118 HYPERLINK https:/www.MedChemE/r-r-bay-y-3118.html HYPERLINK https:/www.MedChemE

31、/s-1-4-hydroxyphenyl-ethane-1-2-diol.html (S)-1-(4-Hydroxyphenyl)ethane-1,2-diolCat. No.: HY-U00092B Cat. No.: HY-W087444A(R,R)-BAY-Y 3118 is the R-enantiomer of BAY-Y3118. (R,R)-BAY-Y 3118 shows weak bactericidalactivity.(S)-1-(4-Hydroxyphenyl)ethane-1,2-diol is anactive constituent of the aerial p

32、arts of Angelicasinensis. (S)-1-(4-Hydroxyphenyl)ethane-1,2-diolsignificantly inhibits the growth of Aeromonashydrophila. Anticoagulative and antibioticactivities.Purity: 99.06%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg, 50 mg, 100 mgPurity: 98%Clinical Data: No Development Repor

33、tedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/s-ofloxacin-d3.html (S)-Ofloxacin-d3Cat. No.: HY-B0330S1 HYPERLINK https:/www.MedChemE/_S_-Tedizolid.html (S)-Tedizolid(S)-TR 700; (S)-DA 7157) Cat. No.: HY-14855A(S)-Ofloxacin-d3 is the deuterium labeledLevofloxacin. Levofloxacin, a syntheticfluoroq

34、uinolone, is an antibacterial agent thatinhibits the supercoiling activity of bacterialDNA gyrase, halting DNA replication.(S)-Tedizolid is the S-enantiomer of Tedizolid.Tedizolid is a novel oxazolidinone with activityagainst Gram-positive pathogens. (S)-Tedizolid isthe less active isomer.Purity: 98

35、%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 95.56%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 50 mg HYPERLINK https:/www.MedChemE/z-chlorprothixene-d6-hydrochloride.html (Z)-Chlorprothixene-d6 HYPERLINK https:/www.MedChemE/z-chlorprothixene-d6-hydrochlorid

36、e.html HYPERLINK https:/www.MedChemE/z-chlorprothixene-d6-hydrochloride.html hydrochloride HYPERLINK https:/www.MedChemE/z-chlorprothixene-d6-hydrochloride.html HYPERLINK https:/www.MedChemE/z-ligustilide.html (Z)-LigustilideCat. No.: HY-B0274S Cat. No.: HY-N0401A(Z)-Chlorprothixene-d6 hydrochloride

37、 is thedeuterium labeled Chlorprothixene. Chlorprothixeneis a dopamine and histamine receptorsantagonist with Ks of 18 nM, 2.96 nM, 4.56 nM, 9inM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1receptors, respectively. Antipsychotic activity.(Z)-Ligustilide is extracted from Ligusticumchuanxiong Hort, has

38、 antimicrobial and antifungalactivity, exhibits an average antifungal score of5.6.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 99.79%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 20 mg HYPERLINK https:/www.MedChemE/racemic-decursinol.html ()-Decursinol HYPERLIN

39、K https:/www.MedChemE/racemic-decursinol.html HYPERLINK https:/www.MedChemE/leucine.html ()-LeucineCat. No.: HY-N2567(DL-Leucine; (RS)-Leucine) Cat. No.: HY-B1674()-Decursinol is a potent FtsZ inhibitor.()-Decursinol inhibits B. anthracis FtsZpolymerization with an IC of 102 M.50()-Leucine (DL-Leuci

40、ne), an isomer of Leucine,chemosterilant and dietary additive. ()-Leucineinhibits growth of Escherichia coli HfrH by92.08%.Purity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mgPurity: 98.0%Clinical Data: No Development ReportedSize: 500 mg, 5 g HYPERLINK https:/www.MedChemE/racemic-leuc

41、ine-13c.html ()-Leucine-13C HYPERLINK https:/www.MedChemE/racemic-leucine-13c.html HYPERLINK https:/www.MedChemE/racemic-leucine-13c-1.html ()-Leucine-13C-1(DL-Leucine-13C; (RS)-Leucine-13C) Cat. No.: HY-B1674S1 (DL-Leucine-13C-1; (RS)-Leucine-13C-1) Cat. No.: HY-B1674S2()-Leucine-13C (DL-Leucine-13

42、C) is the13C-labeled ()-Leucine. ()-Leucine (DL-Leucine),an isomer of Leucine, chemosterilant and dietaryadditive. ()-Leucine inhibits growth ofEscherichia coli HfrH by 92.08%.()-Leucine-13C-1 (DL-Leucine-13C-1) is the13C-labeled ()-Leucine. ()-Leucine (DL-Leucine),an isomer of Leucine, chemosterila

43、nt and dietaryadditive. ()-Leucine inhibits growth ofEscherichia coli HfrH by 92.08%.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg4 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedCh

44、emE/racemic-leucine-d10.html ()-Leucine-d10(DL-Leucine-d10; (RS)-Leucine-d10) Cat. No.: HY-B1674S HYPERLINK https:/www.MedChemE/racemic-leucine-d7.html ()-Leucine-d7(DL-Leucine-d7; (RS)-Leucine-d7) Cat. No.: HY-B1674S4()-Leucine-d10 (DL-Leucine-d10) is the deuteriumlabeled ()-Leucine. ()-Leucine (DL

45、-Leucine), anisomer of Leucine, chemosterilant and dietaryadditive. ()-Leucine inhibits growth ofEscherichia coli HfrH by 92.08%.()-Leucine-d7 is the deuterium labeled()-Leucine. ()-Leucine (DL-Leucine), an isomerof Leucine, chemosterilant and dietary additive.()-Leucine inhibits growth of Escherich

46、ia coliHfrH by 92.08%.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/racemic-9-hpode.html ()9-HpODE HYPERLINK https:/www.MedChemE/racemic-9-hpode.html HYPERLINK https:/www.MedChemE/1-3-d

47、ihydroxy-4-methoxy-10-methylacridin-9-10h-one.html 1,3-Dihydroxy-4-methoxy-10-methylacridin-9(10H)-oneCat. No.: HY-118149A Cat. No.: HY-128913()9-HpODE is a long chain lipid hydroperoxide, isa product of linoleic acid peroxidation.()9-HpODE can induce oxidation of intracellularglutathione (GSH). ()9

48、-HpODE also exhibitsantimicrobial activity against various fungal andbacterial pathogens.1,3-Dihydroxy-4-methoxy-10-methylacridin-9(10H)-one is an acridone alkaloid compound isolated fromthe fruits of Z. leprieurii and Z. zanthoxyloides.1,3-Dihydroxy-4-methoxy-10-methylacridin-9(10H)-onehas antibact

49、erial activity.Purity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/1-3-dithiane.html 1,3-DithianeCat. No.: HY-W001189 HYPERLINK https:/www.MedChemE/1-deoxynojirimycin-hydrochloride.ht

50、ml 1-Deoxynojirimycin HYPERLINK https:/www.MedChemE/1-deoxynojirimycin-hydrochloride.html HYPERLINK https:/www.MedChemE/1-deoxynojirimycin-hydrochloride.html hydrochloride(Duvoglustat hydrochloride) Cat. No.: HY-14860A1,3-Dithiane is a protected formaldehyde anionequivalent that could serve as a use

51、ful labeledsynthon. 1,3-Dithiane is also a sulfur-containingMaillard reaction products (MRPs) found in boiledbeef extracts.1-Deoxynojirimycin hydrochloride (Duvoglustathydrochloride) is a potent and orally active-glucosidase inhibitor. 1-Deoxynojirimycinhydrochloride suppresses postprandial bloodglu

52、cose and is widely used for diabetes mellitus.Purity: 98.0%Clinical Data: No Development ReportedSize: 500 mgPurity: 98%Clinical Data: Phase 2Size: 5 mg, 10 mg, 25 mg HYPERLINK https:/www.MedChemE/1-heptadecanol.html 1-Heptadecanol HYPERLINK https:/www.MedChemE/1-heptadecanol.html HYPERLINK https:/w

53、ww.MedChemE/1-hydroxy-2-butanone.html 1-Hydroxy-2-butanoneCat. No.: HY-W004296 Cat. No.: HY-W0053271-Heptadecanol is a long-chain primary alcoholwith antibacterial activity from Solenaamplexicaulis leaves.1-Hydroxy-2-butanone is a natural compoundisolated from Bomboo Juice with antitubercularactivit

54、y.Purity: 98%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 500 mgPurity: 96.0%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 250 mg HYPERLINK https:/www.MedChemE/1-hydroxy-2-methylanthraquinone.html 1-Hydroxy-2-methylanthraquinone HYPERLINK https:/www.MedChemE/1-hydroxy-2-methylan

55、thraquinone.html HYPERLINK https:/www.MedChemE/1-Kestose.html 1-KestoseCat. No.: HY-N1625 Cat. No.: HY-N25791-Hydroxy-2-methylanthraquinone exhibitsantimicrobial, antioxidant, pesticidal, andanti-inflammatory activities.1-Kestose, the smallest fructooligosaccharidecomponent, which efficiently stimul

56、atesFaecalibacterium prausnitzii as well asBifidobacteria.Purity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mgPurity: 99.01%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 10 mg, 25 mgwww.MedChemE 5 HYPERLINK https:/www.MedChemE/1-methoxyphaseollidin.html 1-Methoxyphaseo

57、llidin HYPERLINK https:/www.MedChemE/1-methoxyphaseollidin.html HYPERLINK https:/www.MedChemE/1-methyl-2-4z-7z-4-7-tridecadienyl-4-1h-quinolone.html 1-Methyl-2-(4Z,7Z)-4,7-tridecadienyl-4(1H)-quinoloneCat. No.: HY-N8489 Cat. No.: HY-N95301-Methoxyphaseollidin, a flavonoid compound, is alysoPAF acety

58、ltransferase inhibitor, with an IC of5048 M. 1-Methoxyphaseollidin exhibits anti-H.pyloriactivity against the CLAR and AMOX-resistantstrain as well as four CLAR (AMOX)-sensitivestrains.1-Methyl-2-(4Z,7Z)-4,7-tridecadienyl-4(1H)-quinolone, a quinolone alkaloid, is a diacylglycerolacyltransferase inhi

59、bitor and angiotensin IIreceptor blocker, with IC s of 20.1 M and 34.150M, respectively.Purity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mgPurity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg HYPERLINK https:/www.MedChemE/1-monomyristin.html 1-MonomyristinC

60、at. No.: HY-N2512 HYPERLINK https:/www.MedChemE/1-naphthalenemethanol.html 1-Naphthalenemethanol(1-Hydroxymethylnaphthalene) Cat. No.: HY-W0172411-Monomyristin, extracted from Serenoa repens,inhibits the hydrolysis of 2-oleoylglycerol(IC =32 M) and fatty acid amide hydrolase (FAAH)50activity (IC =18