一氧化氮在人體所扮演角色-課件

1、The Role of Nitric Oxide in the Body How NitroFX Fills the Void 一氧化氮在人體所扮演的角色 及尼多樂(lè)如何補(bǔ)強(qiáng)其效果 Thomas J. Burke, PhDScientific Advisory BoardEnliven International茵萊國(guó)際科學(xué)顧問(wèn)：湯瑪斯柏克 博士What is Nitric Oxide (NO)?一氧化氮是什麼Most powerful endogenous vasodilator 人體本身最有效的血管擴(kuò)張劑 (keeps blood vessels open and blood flowing

2、 to tissues) (保持血管擴(kuò)張並使血液能流向各組織)Discovered in 1988 於2019年被發(fā)現(xiàn)Nobel Prize for NO in 2019 此發(fā)現(xiàn)於2019年獲得諾貝爾獎(jiǎng)Dont EVER say “nitrous oxide” 絕對(duì)別說(shuō)它是”含氮的氧化物”Where does NO come from?一氧化氮從哪裡而來(lái)L-arginine, one of the 20 amino acids that form proteinL精氨酸, 蛋白質(zhì)內(nèi)所含20種氨基酸的其中一項(xiàng)Nutrition is important in health outcomes營(yíng)養(yǎng)是

3、人體健康最重要的基礎(chǔ)What (else) does NO do in the body?一氧化氮在人體還有其他功能嗎?Improved immune system改善免疫系統(tǒng)Inhibits pain抑制疼痛Antibacterial抗菌Enhanced nerve function增強(qiáng)神經(jīng)功能Antiviral抵抗病毒How does NO do these various things?一氧化氮如何運(yùn)作這麼多事情?NO is a gas and is “free” for only 1-2 seconds一氧化氮是一種氣體, 而且釋放後只存在1-2秒NO QUICKLY binds to

4、 proteins and peptides including enzymesand these “activated” proteins exert their effects for up to 6 hours!一氧化氮能快速將蛋白質(zhì), 縮氨酸, 及多種酵素結(jié)合, 這些活化的蛋白質(zhì)能使一氧化氮效果長(zhǎng)達(dá)6個(gè)小時(shí)之久!Any “extra” NO is rapidly converted to very stable nitrates and nitrites任何多餘的一氧化氮都會(huì)快速地轉(zhuǎn)化為非常穩(wěn)定的硝酸物及亞硝酸物So, whats all this have to do with Ni

5、troFX?那麼, 以上這些要和尼多樂(lè)如何一起運(yùn)作呢?NitroFX contains large amounts of nitrates and nitrites.尼多樂(lè)含有大量的硝酸物及亞硝酸物NO must have been previously formed by M.citrifolia! 所以一氧化氮一定會(huì)被諾麗果提前形成! Plants do form NO and nitrates and nitrites植物確實(shí)能形成一氧化氮,硝酸物及亞硝酸物Prove it! 證據(jù)!Science. 2019 Oct 3;302(5642):100-3. 科學(xué)期刊, 2019年10月,

6、第302期(5642):100-103頁(yè)Identification of a plant nitric oxide synthase gene involved in hormonal signaling.題目: 植物的一氧化氮綜合基因與荷爾蒙信號(hào)有關(guān)的證明Guo FQ, Okamoto M, Crawford NM. (作者)Yes, plants make nitric oxide!是的, 植物能形成一氧化氮!Prove it! 證據(jù)!Phytochemistry. 2019 Apr;65(7):783-92. 植物化學(xué)期刊, 2019年4月, 第65期(7):783-792頁(yè)Nitri

7、c oxide and nitric oxide synthase activity in plants.題目:一氧化氮與一氧化氮綜合體在植物內(nèi)的活動(dòng)情形del Rio LA, Corpas FJ, Barroso JB. (作者)Ingesting NitroFXwhat happens next?食用尼多樂(lè)後會(huì)有什麼情形Nitrates and nitrites are converted to NO gas in the stomach in the presence of stomach acid.在胃酸中的硝酸物及亞硝酸物會(huì)轉(zhuǎn)化成一氧化氮?dú)怏wNO gas: 一氧化氮?dú)怏w會(huì)- diff

8、uses through the stomach wall into the blood stream, 從胃壁擴(kuò)散到血液中 - is taken up by red blood cells and 並經(jīng)由紅血球攜帶 - is carried to all parts of the body! 輸送到全身各部位Prove it! 證據(jù)!Gut. 2019 Feb;40(2):211-4.內(nèi)臟期刊, 2019年2月, 第40期(2):211-214頁(yè)Chemical synthesis of nitric oxide in the stomach from dietary nitrate in

9、humans.題目:從人體內(nèi)的硝化物到一氧化氮的化學(xué)綜合物McKnight GM, Smith LM, Drummond RS, Duncan CW, Golden M, Benjamin N.(作者)Take away message將訊息帶走NitroFX should increase a persons stores of NO!尼多樂(lè)能增加人體內(nèi)一氧化氮的儲(chǔ)存量That increased NO can help to:這些增加的一氧化氮能幫助我們Decrease pain 減低疼痛Repair damaged tissue 修復(fù)受損組織Speed up fracture heali

10、ng 加速骨折的復(fù)原Improve the immune system 改善免疫系統(tǒng)Fight off infections and viruses 抵抗傳染病及病毒And if that werent enough如果還不夠的話NitroFX contains “something” that stimulates our natural production of NO尼多樂(lè)含有某種東西能刺激一氧化氮的自然產(chǎn)物The first suspicion that this was the case came in 2019. 第一次被推測(cè)有此可能的是由於2019年的一件案子Phytother

11、Res. 2019 Aug;13(5):380-7.植物療法期刊, 2019年8月, 第13期(5):380-387頁(yè) An immunomodulatory polysaccharide-rich substance from the fruit juice of Morinda citrifolia (noni) with antitumour activity.題目: 諾麗果汁在抗腫瘤活動(dòng)中所產(chǎn)生的有如免疫調(diào)節(jié)器的豐富多醣類物質(zhì)Hirazumi A, Furusawa E. (作者)From their abstract 該文摘要“Noni-ppt was also capable of

12、 stimulating the release of several mediators from murine effector cells, including tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-10, IL-12 p70, interferon-gamma (IFN-gamma) and nitric oxide (NO)”諾麗能夠刺激白老鼠神經(jīng)末端受動(dòng)器細(xì)胞, 釋出多種介體, 包括腫瘤壞死因子、IL-1beta 、IL-10 、IL12p70 、干擾素及一氧化氮Inte

13、grated Systems Physiology綜合系統(tǒng)生理學(xué)NitroFX contains large amounts of nitrates尼多樂(lè)含有大量的硝化物 and nitrites以及亞硝酸物And而且NitroFX stimulates endothelial cells to produce nitric oxide尼多樂(lè)能刺激內(nèi)覆組織細(xì)胞產(chǎn)生一氧化氮Conclusion 結(jié)論A. Hirazumi was correctnoni contains “something” that stimulates cells to produce NO.A.Hirazumi 是對(duì)的,

14、 諾麗含有某種東西能刺激細(xì)胞產(chǎn)生一氧化氮Nitric oxide and fracture healing一氧化氮與骨折的復(fù)原J Bone Miner Res. 2000 Feb;15(2):342-51. J 骨質(zhì)研究期刊, 2000年2月, 第15期(2):342-351頁(yè)Nitric oxide modulates fracture healing.題目: 一氧化氮對(duì)骨折復(fù)原的調(diào)節(jié)Diwan AD, Wang MX, Jang D, Zhu W, Murrell GA. (作者)Nitric oxide and wounds一氧化氮與傷口Curr Opin Clin Nutr Metab

15、 Care. 2000 May;3(3):197-204. Curr Opin Clin Nutr Metab Care期刊, 2000年5月, 第3期(3):197-204頁(yè)Role of nitric oxide in wound healing.一氧化氮在傷口痊癒所扮演的角色Efron DT, Most D, Barbul A. (作者)Nitric oxide and pain一氧化氮與疼痛Eur J Pharmacol. 1991 Aug 16;201(1):121-2.Eur J 藥物學(xué) 期刊,1991年8月, 第16;201期(1):121-122頁(yè)The molecular m

16、echanism of action of peripheral morphine analgesia: stimulation of the cGMP system via nitric oxide release.體表麻醉劑止痛行為的分子機(jī)制: 經(jīng)由一氧化氮釋放而刺激環(huán)狀鳥(niǎo)糞核糖苷單磷酸鹽系統(tǒng)Ferreira SH, Duarte ID, Lorenzetti BB. (作者)L-arginine and immune function L精氨酸及免疫功能N Engl J Med. 1993 Dec 30;329(27):2019-12. N Engl J Med 期刊,1993年12月,

17、 第30;329期(27):2019-2019頁(yè)The L-arginine-nitric oxide pathway. L精氨酸-一氧化氮路徑Moncada S, Higgs A. (作者)L-arginine and immune system L精氨酸及免疫系統(tǒng)Postepy Hig Med Dosw 2019 Sep 1;58:321-32. Postepy Hig Med Dosw 期刊,2019年9月, 第1;58期:321-332頁(yè)Arginine-metabolism and functions in the human organism精氨酸人類生物體內(nèi)的新陳代謝及功能Sci

18、bior D, Czeczot H. (作者)When you see L-arginine, think NitroFX and nitric oxidefrom their abstract當(dāng)你看到L精氨酸就想到一氧化氮(從以上論文的摘要)” L-arginine administration improves cardiovascular, pulmonary, immune, and digestive functions and protects against the early stages of cancerogenesis.”L精氨酸能改善心血管的, 肺部的, 免疫力的, 及

19、消化的功能, 並能抵禦癌細(xì)胞的初期活動(dòng)Mini summary 簡(jiǎn)論NitroFX increases nitric oxide尼多樂(lè)能增加一氧化氮, 而一氧化氮能NO reduces pain 減輕疼痛NO heals broken bones 治癒受創(chuàng)骨骼NO improves the rate and quality of wound healing 促進(jìn)傷口癒合的速度及品質(zhì)NO improves immune function改善免疫功能NitroFX does ONE thingNO does many, many things尼多樂(lè)做了一件事(增加一氧化氮), 而一氧化氮就做了許多

20、許多事Cardiovascular 心血管NO inhibits platelets from sticking to vessels walls (think about 81mg baby aspirin)一氧化氮能抑制血小板阻塞血管壁 (想想看81毫克的小劑量阿斯匹林)NO dilates existing blood vessels一氧化氮能擴(kuò)張血管壁NO grows new blood vessels after injury一氧化氮能在血管受損後增生新的血管More on “Cardiovascular”更多有關(guān)心血管的Dilating existing blood vessels

21、 and growing new blood vessels means more oxygen, nutrients, vitamins and growth factors delivered to tissues.擴(kuò)張心血管及增生新的心血管意謂著有更多的氧氣, 養(yǎng)分, 維生素, 及成長(zhǎng)因子輸送到組織去Fibromyalgia pain纖維肌疼痛 (one of 17 medical papers) 17篇醫(yī)學(xué)論文中的一篇Rheumatology (Oxford). 2000 Aug;39(8):917-21.風(fēng)濕病學(xué)(牛津)期刊, 2000年8月, 第39(8)期: 917-921頁(yè) A

22、bnormal microcirculation and temperature in skin above tender points in patients with fibromyalgia.輕觸纖維肌疼痛患者皮膚而產(chǎn)生異常的微循環(huán)及溫度Jeschonneck M, Grohmann G, Hein G, Sprott H.(作者)From their abstract 根據(jù)以上論文摘要“CONCLUSION: Vasoconstriction occurs in the skin above tender points in FM patients”結(jié)論: 輕觸纖維肌疼痛患者的皮膚會(huì)發(fā)

23、生血管緊縮(Remember, vasoconstriction means decreased blood flow and NO increases blood flow.)(記住, 血管緊縮就是血流量減少, 而一氧化氮能增加血流量)Sickle cell and nitric oxide鐮狀細(xì)胞及一氧化氮Pediatr Pathol Mol Med. 2019 20(1):1-13. Pediatr Pathol Mol Med 期刊, 2019年, 第20期(1):1-13頁(yè)Exciting new treatment approaches for pathophysiologic m

24、echanisms of sickle cell disease.目前已獲認(rèn)同對(duì)於鐮狀細(xì)胞疾病的生理疼痛機(jī)制的新治療方法Mankad VN. (作者)From his abstract 該文摘要“Other promising therapies include butyrate compounds, clotrimazole, magnesium supplementation, poloxamer 188, antiadhesion agents, anticoagulant approaches, and nitric oxide.”其他有希望的治療方法包括: 酪酸鹽化合物,抗生素, 鎂補(bǔ)充劑,聚醚188, 抗黏著劑, 抗凝血法, 及一氧化氮 Virus replication濾過(guò)性病原體複製Lancet Infect Dis. 2019 May;2(5):273-80.Lancet Infect Dis期刊, 2019年5月, 第2期(5):273-280頁(yè) Role of nitric oxide in HIV-1 infection: friend or foe?一氧化氮在”人類免疫缺陷病毒1型”(愛(ài)滋病1型)中所扮演的角色: 是敵是友?Torre D, Pugliese A, Speranza F. (作者)From the