Rifabutin-Ansamycin-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemERifabutinCat. No.: HY-17025CAS No.: 72559-06-9Synonyms: Ansamycin; LM-427分式: CHNO分量: 847作靶點: Bacterial作通路: Anti-infection儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 100 mg/mL (118.06 mM

2、)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 1.1806 mL 5.9032 mL 11.8064 mL5 mM 0.2361 mL 1.1806 mL 2.3613 mL10 mM 0.1181 mL 0.5903 mL 1.1806 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗 請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實驗結(jié)果的可靠性，體內(nèi)實

3、驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (2.95 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 Rifabutin (Ansamycin)半合成的安莎霉素抗素，具有抗分枝桿菌特性。IC50 & Target Antiba

4、cterial體外研究 Rifabutin is primarily bactericidal antibiotic drug used to treat tuberculosis. Its effect on bacteria is based onthe DNA-dependent RNA polymerase blocking drug rifamycin S., a semi-synthetic derivative. It is effective,for example, in highly resistant mycobacteria, Gram-positive bacteri

5、a (and some are effective against Gram-negative bacteria), but also against Mycobacterium tuberculosis, M. leprae, and M. aviumintracellulare.Rifabutin is an antibiotic; antitumor. Rifabutin interferes with HSP-90 molecular chaperone,enhances ubiquitination and protein degradation, and inactivates b

6、acterial RNA polymerase.REFERENCES1. Review Article: Rifabutin in the Treatment of Refractory Helicobacter pylori Infection J. P. Gisbert, X. Calvet Issue AlimentaryPharmacology & Therapeutics Volume 35, Issue 2, pages 209-221, January 20122. Vourvahis M, Davis J, Wang R, Layton G, Choo HW, Chong CL

7、, Tawadrous M.Effect of rifampin and rifabutin on the pharmacokineticsof lersivirine and effect of lersivirine on the pharmacokinetics of rifabutin and 25-o-desacetyl-rifabutin in healthy subjects.Antimicrob AgentsChemother. 2012 Aug;56(8):4303-9.3. Gisbert JP, Castro-Fernandez M, Perez-Aisa A, Cosm

8、e A, Molina-Infante J, Rodrigo L, Modolell I, Cabriada JL, Gisbert JL, Lamas E,Marcos E, Calvet X.Fourth-line rescue therapy with rifabutin in patients with three Helicobacter pylori eradication failures.Aliment PharmacolTher. 2012 Apr;35(8):941-7. doi: 10.1111/j.1365-2036.2012.05053.x.4. Gisbert JP

9、, Calvet X.Review article: rifabutin in the treatment of refractory Helicobacter pylori infection.Aliment Pharmacol Ther. 2012Jan;35(2):209-21. doi: 10.1111/j.1365-2036.2011.04937.x.5. Horne DJ, Spitters C, Narita M.Experience with rifabutin replacing rifampin in the treatment of tuberculosis.Int J Tuberc Lung Dis. 2011Nov;15(11):1485-9, i.McePdfHeightCaution: Product has not been fully validated for med