Balapiravir-Ro-4588161-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEBalapiravirCat. No.: HY-10443CAS No.: 690270-29-2Synonyms: Ro 4588161; R1626分式: CHNO分量: 494.5作靶點: HCV作通路: Anti-infection儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 100 mg/mL (202.22 mM)

2、* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.0222 mL 10.1112 mL 20.2224 mL5 mM 0.4044 mL 2.0222 mL 4.0445 mL10 mM 0.2022 mL 1.0111 mL 2.0222 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實驗結(jié)果的可靠性，體內(nèi)實驗

3、的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.06 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (5.06 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師ww

4、w.MedChemE3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (5.06 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Balapiravir (R1626, Ro 4588161)是R1479（RG1479）的原藥，是HCV的RNA聚合酶核苷類似物抑制劑。戶使本產(chǎn)品發(fā)表的科研獻 J Infect Dis. 2016 Sep 1;214(5):707-11. Antivir Res. 2019 Jul. Antiviral Res. 2016 Sep;133:119-29.See mo

5、re customer validations on HYPERLINK / www.MedChemEREFERENCES1. Nguyen NM, et al. A randomized, double-blind placebo controlled trial of balapiravir, a polymerase inhibitor, in adult dengue patients. JInfect Dis. 2013 May 1;207(9):1442-1450.2. Nelson DR, et al. Balapiravir plus peginterferon alfa-2a

6、 (40KD)/ribavirin in a randomized trial of hepatitis C genotype 1 patients.AnnHepatol. 2012 Jan-Feb;11(1):15-31.3. Li F, et al. Chemical stability of 4-azidocytidine and its prodrug balapiravir.Drug Dev Ind Pharm. 2010 Apr;36(4):413-20.4. kros PJ, et al. R1626 plus peginterferon Alfa-2a provides pot

7、ent suppression of hepatitis C virus RNA and significant antiviral synergy incombination with ribavirin.Hepatology. 2008 Aug;48(2):385-97.5. Roberts SK, et al. Robust antiviral activity of R1626, a novel nucleoside analog: a randomized, placebo-controlled study in patients withchronic hepatitis C.Hepatology. 2008 Aug;48(2):398-406.6. Chen YL, et al. Activation of peripheral blood mononuclear cells by dengue virus infection depotentiates balapiravir. J Virol. 2014Feb;88(3):1740-1747.McePdfHeightCaution: Product has not been fully validated for medical applications.For r