MC3482 - Sirtuin 抑制劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMC3482Cat. No.: HY-112587分式: CHNO分量: 618.68作靶點(diǎn): Sirtuin作通路: Cell Cycle/DNA Damage; Epigenetics儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 130 mg/mL (210.12 mM)H2O : 40% PEG300 5% Tween-

2、80 45% salineSolubility: 2.17 mg/mL (3.51 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.17 mg/mL (3.51 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 MC3482種特異性sirtuin5 (SIRT5) 抑制劑。IC50 & Target SIRT5 1體外研究 MC3482 inhibits sirtuin5. 5

3、0 M MC3482 inhibits SIRT5 desuccinylating activity without affecting SIRT5intracellular expression levels. Autophagy and mitophagy increase in SIRT5-silenced cells and in WT cellstreated with MC3482 and decrease in SIRT5-overexpressing cells 1.PROTOCOLCell Assay 1 MDA-MB-231 and C2C12 cells are trea

4、ted with 50M of SIRT5 inhibitor MC3482 for 24 h. Ammonia levelsare measured in the culture medium every other day 1.MCE has not independently confirmed the accuracy of these methods. They are for reference only.REFERENCES1. Polletta L, et al. SIRT5 regulation of ammonia-induced autophagy and mitophagy. Autophagy. 2015;11(2):253-70.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax