Sarafloxacin-hydrochloride-A-56620-hydrochloride-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESarafloxacin hydrochlorideCat. No.: HY-B0343ACAS No.: 91296-87-6Synonyms: A-56620 hydrochloride分式: CHClFNO分量: 421.83作靶點(diǎn): Bacterial作通路: Anti-infection儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn)

2、 DMSO : 7.8 mg/mL (18.49 mM; Need ultrasonic and warming)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.3706 mL 11.8531 mL 23.7062 mL5 mM 0.4741 mL 2.3706 mL 4.7412 mL10 mM 0.2371 mL 1.1853 mL 2.3706 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Sarafloxacin (hydrochlori

3、de) (A-56620 (hydrochloride)是抗菌化合物。IC50 & Target Antibacterial 1.體外研究Sarafloxacin (hydrochloride) is a fluoroquinolone antibiotic registered for use against poultry diseases.Sarafloxacin treatment demonstrated mineralization to 14CO2 amounting to 0.58%, 0.49%, and 0.57% in1/2 Master of Small Molecul

4、es 您邊的抑制劑師www.MedChemEloam, silt loam, and sandy loam soils, respectively, at the termination of the test 1. The inhibitory level ofsarafloxacin for the tested bacteria was strain dependent. It appeared that in broth culture Escherichia coliisolates were sensitive to sarafloxacin concentrations 5-fo

5、ld lower than the concentrations present in thesimulated gut model, suggesting that sarafloxacin may be partially unavailable due to absorption to organicmatter in the model 2.體內(nèi)研究 Administering Sarafloxacin (hydrochloride) in the feed for 5 d at a dose of 10 or 12.5 mg/kg of fish provedefficacious

6、in treating channel catfish infected with E. ictaluri in all three field trials. Average survival of thenonmedicated group was 43% in trial 1, 11% in trial 2, and 59% in trial 3. Survival of the correspondingSarafloxacin hydrochloride-medicated groups averaged 68, 48, and 73%. Antibiotic therapy wit

7、h Sarafloxacinhydrochloride significantly (P 0.05) improved survival in all trials 3.REFERENCES1. Marengo, J.R., et al., Aerobic biodegradation of (14C)-sarafloxacin hydrochloride in soil. Environmental Toxicology and Chemistry, 1997.16(3): p. 462-471.2. McConville, M.L., et al., Effects of saraflox

8、acin hydrochloride on human enteric bacteria under simulated human gut conditions. Vet Q,1995. 17(1): p. 1-5.3. Johnson, M.R., K.L. Smith, and C.R. Boyle, Field efficacy trials of the antibacterial sarafloxacin-hydrochloride (A-56620) for treatment ofEdwardsiella ictaluri infections in channel catfish. Journal of aquatic animal health, 1992. 4(4): p. 244-251.McePdfHeightCaution: Product has not been fully validated for medical applicati