Hederagenin - Terpenoids and Glycoside - 生命科學(xué)試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEHederageninCat. No.: HY-N0256CAS No.: 465-99-6分式: CHO分量: 472.7作靶點(diǎn): Others作通路: Others儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 50 mg/mL (105.78 mM; Need ultrasonic)Mass Solvent1 mg 5 m

2、g 10 mg Concentration制備儲(chǔ)備液1 mM 2.1155 mL 10.5775 mL 21.1551 mL5 mM 0.4231 mL 2.1155 mL 4.2310 mL10 mM 0.2116 mL 1.0578 mL 2.1155 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積

3、占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (5.29 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (5.29 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE物活性 Hederagenin是三萜皂苷，能夠抑制細(xì)胞中由于LPS刺激引起的 iNOS, COX-2,

4、和 NF-B的表達(dá)。REFERENCES1. Su-Hong Lu et al. Experimental Study of Antiatherosclerosis Effects with Hederagenin in Rats. Evid Based Complement Alternat Med,2015, Oct 192. Diego Rodrguez-Hernndez et al. Hederagenin as a triterpene template for the development of new antitumor compounds. Eur J MedChem, 20

5、15 Nov 13, 105:57-623. Chul Won Lee et al. Hederagenin, a major component of Clematis mandshurica Ruprecht root, attenuates inflammatory responses inRAW 264.7 cells and in mice. Int Immunopharmacol, 2015 Dec, 29(2):528-37.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-589