Epiberberine-chloride - AChE 抑制劑 - 生命科學(xué)試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEEpiberberine chlorideCat. No.: HY-N0226ACAS No.: 889665-86-5分式: CHClNO分量: 371.81作靶點(diǎn): AChE; Beta-secretase; Reactive Oxygen Species作通路: Neuronal Signaling; Immunology/Inflammation; MetabolicEnzyme/Protease; NF-B儲(chǔ)存式: Powder -20C 3

2、 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 7.4 mg/mL (19.90 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.6895 mL 13.4477 mL 26.8955 mL5 mM 0.5379 mL 2.6895 mL 5.3791 mL10 mM 0.2690 mL 1.3448 mL 2.6895 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限

3、。BIOLOGICAL ACTIVITY物活性 Epiberberine chloride從 連中得到的物堿，為有效的 AChE 和 BChE 抑制劑，和競(jìng)爭(zhēng)性的 BACE1 抑制劑，IC50 值分別為 1.07，6.03 和 8.55 M。Epiberberine chloride 具有抗氧化作，能夠清除 ONOO-(IC50，16.83 M)，對(duì)阿爾滋海默癥和糖尿病 3有潛在治療作 1。在 3T3-L1 細(xì)胞分化早期，Epiberberine chloride 能夠下調(diào) Raf/MEK1/2/ERK1/2 和 AMPK/Akt 信號(hào)通路 3。體外研究Epiberberine (0, 12.

4、5, 25, or 50 M) dose-dependently inhibits cellular triglyceride accumulation in 3T3-L11/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEadipocytes, with an IC50 of 52.8 M 2.Epiberberine (12.5-50 M) suppresses the Raf/MEK1/ERK1/2 and AMPK/Akt pathways in the early stage of3T3-L1 adipocyte differentiat

5、ion 2.Epiberberine (0.2, 1, 5 g/mL) inhibits glucose uptake in HepG2 cells in a concentration-dependent manner3.體內(nèi)研究 Epiberberine (225 mg/kg, p.o. daily for 40 days) reduces body weight, food consumption, water intake, andurinary output of KK-Ay mice 3.REFERENCES1. Jung HA, et al. Anti-Alzheimer and

6、 antioxidant activities of Coptidis Rhizoma alkaloids. Biol Pharm Bull. 2009 Aug;32(8):1433-8.2. Choi JS, et al. Anti-adipogenic effect of epiberberine is mediated by regulation of the Raf/MEK1/2/ERK1/2 and AMPK/Akt pathways.Arch Pharm Res. 2015 Dec;38(12):2153-62.3. Ma H, et al. Antihyperglycemia and Antihyperlipidemia Effect of Protoberberine Alkaloids From Rhizoma Coptidis in HepG2 Cell andDiabetic KK-Ay Mice. Drug Dev Res. 2016 Jun;77(4):163-70.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only