LCL521-DataSheet-生命科學試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemELCL521Cat. No.: HY-103593CAS No.: 1226851-11-1分式: CHNO分量: 592.77作靶點: Others作通路: Others儲存式: Pure form -20C 3 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 165 mg/mL (278.35 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10

2、 mg Concentration制備儲備液1 mM 1.6870 mL 8.4350 mL 16.8699 mL5 mM 0.3374 mL 1.6870 mL 3.3740 mL10 mM 0.1687 mL 0.8435 mL 1.6870 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗 請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍福渲魄罢埾扰渲瞥蔚膬湟?，再依次添加助溶?為保證實驗結果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請

3、依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.75 mg/mL (4.64 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.75 mg/mL (4.64 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.75 mg/mL (4.64 mM); Clear solution1/2 Master of Small

4、Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 LCL521種酸性神經(jīng)酰胺酶 (ACDase) 抑制劑。LCL521 還抑制溶酶體酸性鞘磷脂酶 (ASMase)。IC50 & Target ACDase, ASMase 1體外研究 LCL521 (1 M) acts as a potent inhibitor of cellular ACDase activity, whereas 10 M LCL521 has anadditional, decreased affect on the -form of this enzyme. LCL

5、521 (10 M) causes a time-dependent (1hours and 5 hours) decrease of the -ACDase form in MCF7 cells 1.REFERENCES1. Bai A, et al. Targeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs.Bioorg Med Chem. 2014 Dec 15;22(24):6933-44.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021