L-Lysine-hydrochloride - Other - 生命科學(xué)試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEL-Lysine hydrochlorideCat. No.: HY-N0470CAS No.: 657-27-2分式: CHClNO分量: 182.65作靶點(diǎn): Others作通路: Others儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) H2O : 100 mg/mL (547.50 mM)* means soluble, but s

2、aturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 5.4750 mL 27.3748 mL 54.7495 mL5 mM 1.0950 mL 5.4750 mL 10.9499 mL10 mM 0.5475 mL 2.7375 mL 5.4750 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 L-lysine hydrochloride類必需的氨酸，具有多種益處，包括治療疹，增加鈣吸收，減少糖尿病相關(guān)疾病和改腸道健康

3、。體內(nèi)研究L-lysine treatment attenuates pancreatic tissue injury induced by L-arginine by inhibiting the release of theinflammatory cytokine IL-6 and enhances antioxidant activity. Pre- or post-treatment with L-lysine leads tosignificant decreases in the levels of malondialdehyde and nitric oxide, while

4、significant enhancement is1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEobserved in the activities of antioxidant enzymes (superoxide dismutase, catalase, and glutathioneperoxidase) and glutathione 1. L-lysine supplementation almost completely ameliorates vascularcalcification. Dietary L-lysine s

5、trongly suppresses plasma intact parathyroid hormone in adenine rats andsupports a proper bone-vascular axis. The conserved orientation of the femoral apatite in group Lys alsoevidences the bone-protective effects of L-lysine. Dietary L-lysine elevates plasma alanine, proline, arginine,and homoargin

6、ine but not lysine 2. The dose-dependent delay in gastric emptying observed in rats isconfirmed in humans with an increase in halftime of gastric emptying of 4 min/g L-lysine. Moreover, a dose-dependent increase in intestinal fluid accumulation is observed (0.4 mL/min/g L-lysine) 3.PROTOCOLAnimal Ra

7、ts: Nephrocalcinosis in 6-week-old male Wistar rats is induced by continuous injection of rat PTH 1-34 at aAdministration 12 dosage of 40 g/kg per day via an osmotic mini-pump for 50 hours. L-lysine HCl or glycine at a dose of 20mmol/kg is administered via a gastric tube at 2 hours, 14 hours, 26 hou

8、rs, and 38 hours after the implantationof the osmotic pump. At the indicated periods, Serum and urinary biochemical parameters, urea nitrogen,albumin, calcium, inorganic phosphate, and magnesium are determined by clinical diagnostic reagents 2.Mice: Four groups of mice (10 in each group) are assesse

9、d. Group I is the control. Animals in groups II-IVare injected intraperitoneally with L-arginine hydrochloride (400 mg/kg body weight bw) for 3 days. Group IIIanimals are orally pre-treated with L-lysine(10 mg/kg bw), whereas group IV animals are orally post-treatedwith L-lysine(10 mg/kg bw). Serum

10、samples are subjected to amylase, lipase, transaminase, and interleukin-6 (IL-6) assays. The pancreas is excised to measure the levels of malondialdehyde, nitric oxide, catalase,superoxide dismutase, reduced glutathione, and glutathione peroxidase 1.MCE has not independently confirmed the accuracy o

11、f these methods. They are for reference only.戶使本產(chǎn)品發(fā)表的科研獻(xiàn) Laurea Magistrale in Biomedical Engineering, Politecnico di Milano. 2019 Jun. bioRxiv. 2019 Jan.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Al-Malki AL, et al. Suppression of acute pancreatitis by L-lysinein mice. BMC

12、 Complement Altern Med. 2015 Jun 23;15:193.2. Shimomura A, et al. Dietary L-lysineprevents arterial calcification in adenine-induced uremic rats. J Am Soc Nephrol. 2014Sep;25(9):1954-65.3. Baruffol C, et al. L-lysine dose dependently delays gastric emptying and increases intestinal fluid volume in humans and rats.Neurogastroenterol Motil. 2014 Jul;26(7):999-1009.McePdfHeightCaution