Pinaverium-bromide - Calcium Channel 抑制劑 - 生命科學(xué)試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEPinaverium bromideCat. No.: HY-111613CAS No.: 53251-94-8分式: CHBrNO分量: 591.42作靶點(diǎn): Calcium Channel作通路: Membrane Transporter/Ion Channel; Neuronal Signaling儲(chǔ)存式: Powder -20C 3 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO

2、: 62.5 mg/mL (105.68 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 1.6908 mL 8.4542 mL 16.9085 mL5 mM 0.3382 mL 1.6908 mL 3.3817 mL10 mM 0.1691 mL 0.8454 mL 1.6908 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍福渲魄罢?qǐng)先配制澄的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)

3、的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (3.52 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (3.52 mM); Clear solution3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSol

4、ubility: 2.08 mg/mL (3.52 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 Pinaverium bromide種對(duì)胃腸道具有選擇性的L型 鈣通道 阻滯劑，能有效緩解疼痛、腹瀉和腸道不適，對(duì)腸易激綜合征 (IBS) 患者有良好的治療效果，且不良反應(yīng) 1。IC50 & Target Calcium channel 1.REFERENCES1. Dai Y, et al. Effect of pinaverium bromide on stress-induced colonic smooth muscle contractility disorder in rats. World J Gastroenterol.2003 Mar;9(3):557-61.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;/p>