病理學(xué)總論3損傷的修復(fù)

1、Chapter 2 Repair oftissue damagerepair of tissue damage injury tissue and cells abrasion tissue loss restorerepairdepartment of pathologyDuring repair, the injured tissue is replaced by regeneration of native parenchymal cells completely restore (completely regeneration) by filling of the defect wit

2、h fibroblast scar tissue fibrous scar restore ( pletely regeneration) department of pathologySection 1: Regeneration one cell divided tow cells physiological - normal pathological - abnormaldepartment of pathology2.Regeneration capacity of cells: divided into three groups . labile cells . stable cel

3、ls . permanent cells: department of pathologypermanent cells: normally divide only during fetal life and they cannot be replaced when lose. nerve cell skeletal muscles cells cardiac muscles cellsdepartment of pathologynerve cellcardiac muscles cellsskeletal muscles cellsdepartment of pathologystable

4、 cells: divide very infrequently under normal conditions, but are stimulated to divide rapidly when such cells are lost. Gland organs( Liver,Endocrine gland ) Bone Fibrous tissue Renal tubulesdepartment of pathologyRenal tubuleGland organsFibrous tissuestable cellsdepartment of pathologylabile cells

5、: proliferate continuously in post-natal life, they have a short life-span and a rapid turnover time. except stable, permanent department of pathologySection 2: fibrin repair granulation tissue granulation tissue is formed in the early stage of connective tissue, which consists new capillary and fib

6、roblast,with inflammatory cells infiltrating .department of pathologyGranulation tissue consist of 1. New capillaries 2. New connective tissue ( fibroblast,myofibroblast,collagen) 3. Inflammatory cells department of pathologyNew capillaryCapillary endothelial cellsBase membrane Red cellsdepartment o

7、f pathologyfibroblastcollagenFibrin cell Fibroblast are stimulated to divide and to secrete collagendepartment of pathologyGranulation tissueGranulation tissuedepartment of pathologyMyofibroblast wound repair tissue defect may be reduced by 80% Why ? myofibroblastdepartment of pathologyMyofibroblast

8、sdisplay features and functions of both fibroblast and smooth muscles cells. department of pathologyFunction of granulation tissue: 1.anti-infection and to cover wound surface 2. to fill the tissue loss and wound anization and encapisulation department of pathologySection 3 Wound healing skinThe pro

9、cess of healing of a skin wound depends on the size of the defect. healing by first intention healing by second intention healing under scab department of pathologyhealing by first intentiondepartment of pathologydepartment of pathologydepartment of pathologydepartment of pathologydepartment of pathologyhealing by second intentiondepartment of pathologyhealing under scabdepartment of pathologyHealing of bone fracturedepartment of pathologyPDGFTGF- plateletfibronectincollagengrowth +EGFnutrientsFactors mediating wound healingPDGFTGF- TGF-myofibroblast+