Palmitelaidic-Acid-9-trans-Hexadecenoic-acid-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEPalmitelaidic AcidCat. No.: HY-N2341CAS No.: 10030-73-6Synonyms: 9-trans-Hexadecenoic acid; trans-Palmitoleic acid分式: CHO分量: 254.41作靶點: AMPK; PPAR; Glucokinase作通路: Epigenetics; PI3K/Akt/mTOR; Cell Cycle/DNA Damage;Metabolic Enzy

2、me/Protease儲存式: Pure form -20C 3 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 Ethanol : 100 mg/mL (393.07 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 3.9307 mL 19.6533 mL 39.3066 mL5 mM 0.7861 mL 3.9307 mL 7.8613 mL10 mM 0.3931 mL 1.9653 mL 3.9307 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選

3、擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Palmitelaidic Acid (9-trans-Hexadecenoic acid)棕櫚油酸 palmitoleic acid 的反式異構(gòu)體。 棕櫚油酸 清和組織中最豐富的脂 酸之。IC50 & Target AMPK PPAR Glucokinase體外研究The monounsaturated fatty acid palmitoleate (palmitoleic acid) is one of the most abundant fatty acids in1/2 Master

4、of Small Molecules 您邊的抑制劑師www.MedChemEserum and tissues, particularly adipose tissue and liver. Its endogenous production by stearoyl-CoAdesaturase 1 gives rise to its cis isoform, cis-palmitoleate. Palmitoleic acid has been correlated with multiplecardiometabolic risk factors, including high blood

5、pressure, total cholesterol, TGs, apoA-I, apoB, andendothelial dysfunction 1.體內(nèi)研究 Palmitoleic acid promotes a faster uptake of glucose in the body, associated with higher insulinconcentration. Palmitoleic acid increases the phosphorylation of AMPK, up-regulates glucokinase and down-regulates SREBP-1

6、. Regarding AMPK downstream, palmitoleic acid increases the production of FGF-21 andstimulates the expression of PPAR 2. Palmitoleic acid reduces body weight increase, ameliorates thedevelopment of hyperglycemia and hypertriglyceridemia, and improves insulin sensitivity. Furthermore,palmitoleic acid

7、 down-regulates mRNA expressions of proinflammatory adipocytokine genes (TNF andresistin) in white adipose tissue and lipogenic genes (SREBP-1, FAS, and SCD-1) in liver 3.PROTOCOLAnimal Mice: Male C57BL/6J wild type and PPAR-KO mice are fed a high-fat diet or a standard diet for 12 weeks.Administrat

8、ion 2 In the last two weeks, the HF-fed mice are treated daily with oleic acid (300 mg/kg of body weight) orpalmitoleic acid (00 mg/kg of body weight) by oral gavage. After 12 weeks, the mice are fasted for 6 h,injected with insulin or PBS vehicle. Blood and liver samples are collected and stored fo

9、r the further analysisof RNA and protein expression 2.MCE has not independently confirmed the accuracy of these methods. They are for reference only.戶使本產(chǎn)品發(fā)表的科研獻 J Neurosci Res. 2019 Aug 16.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Frigolet ME, et al. The Role of the Novel

10、 Lipokine Palmitoleic Acid in Health and Disease.2. de Souza CO, et al. Palmitoleic Acid Improves Metabolic Functions in Fatty Liver by PPAR-Dependent AMPK Activation. J Cell Physiol.2016 Dec 7. doi: 10.1002/jcp.25715.3. Yang ZH, et al. Chronic administration of palmitoleic acid reduces insulin resistance and hepatic lipid accumulation in KK-Ay Mice withgenetic type 2 diabetes. Lipids Health Dis. 2011 Jul 21;10:120.McePdfHeightCaution: Product has not been full