Cepharanthine-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECepharanthineCat. No.: HY-N6972CAS No.: 481-49-2分式: CHNO分量: 606.71作靶點(diǎn): HIV; Autophagy; Apoptosis作通路: Anti-infection; Autophagy; Apoptosis儲(chǔ)存式: Please store the product under the recommended conditions inthe COA.溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 1

2、25 mg/mL (206.03 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 1.6482 mL 8.2412 mL 16.4823 mL5 mM 0.3296 mL 1.6482 mL 3.2965 mL10 mM 0.1648 mL 0.8241 mL 1.6482 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，

3、建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (3.43 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (3.43 mM); Clear solutionBIOLOGICAL ACTIVITY物活性Cepharanthine從 Stephania cepharanth

4、a Hayata 中提取的物堿，具有抗炎、抗氧化作 1 2 3。1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemECepharanthine 能減輕肢體缺再灌注 (I/R) 引起的肌和腎臟損傷 3。Cepharanthine 能誘導(dǎo)乳腺癌細(xì)胞發(fā)噬、凋亡和細(xì)胞周 期阻滯 4。Cepharanthine 通過(guò)降低細(xì)胞膜的流動(dòng)性來(lái)抑制 HIV-1 侵 5。REFERENCES1. Huang H, et al. Cepharanthine, an alkaloid from Stephania cepharantha Hayata, inhibits

5、the inflammatory response in the RAW264.7cell and mouse models. Inflammation. 2014 Feb;37(1):235-46.2. Nagano M, et al. Cepharanthine, an anti-inflammatory drug, suppresses mitochondrial membrane permeability transition. Physiol ChemPhys Med NMR. 2003;35(2):131-43.3. Kao MC, et al. Salutary Effects

6、of Cepharanthine against Skeletal Muscle and Kidney Injuries following Limb Ischemia/Reperfusion. EvidBased Complement Alternat Med. 2015;2015:504061.4. Gao S, et al. Cepharanthine Induces Autophagy, Apoptosis and Cell Cycle Arrest in Breast Cancer Cells. Cell Physiol Biochem.2017;41(4):1633-1648.5. Matsuda K, et al. Cepharanthine inhibited HIV-1 cell-cell transmission and cell-free infection via modification of cell membrane fluidity.Bioorg Med Chem Lett. 2014 May 1;24(9):2115-7.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use onl