Sodium-diatrizoate-Diatrizoic-acid-sodium-salt-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESodium diatrizoateCat. No.: HY-B0926ACAS No.: 737-31-5Synonyms: Diatrizoic acid sodium salt; Sodium amidotrizoate分式: CHINNaO分量: 635.9作靶點(diǎn): Others作通路: Others儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性

2、數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 100 mg/mL (157.26 mM; Need ultrasonic)H2O : 50 mg/mL (78.63 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 1.5726 mL 7.8629 mL 15.7257 mL5 mM 0.3145 mL 1.5726 mL 3.1451 mL10 mM 0.1573 mL 0.7863 mL 1.5726 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意

3、儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Sodium diatrizoate種碘化放射造劑。體內(nèi)研究Sodium diatrizoate is an iodinated radiocontrast agent. Histological examination of rat lung tissue shows noacute toxicity or inflammation after insufflation of Sodium diatrizoate nanoparticle agglomerates. Sodium1/2 Master of Small Mol

4、ecules 您邊的抑制劑師www.MedChemEdiatrizoate nanoparticle agglomerates offers a promising radiocontrast agent for safe and effective lungvisualization 1.PROTOCOLAnimal Female Sprague-Dawley rats (200 to 250 grams) are housed in temperature and humidity controlled roomsAdministration 1 with free access to f

5、ood and water and maintained on a 12 h light/dark cycle. Rats are anesthetized by a 67.5mg/kg ketamine, 3.5 mg/kg xylazine and 0.66 mg/kg acepromazine subcutaneous cocktail. While underanesthesia, rats are placed on a heating pad to maintain a body temperature of 37C. Sodium diatrizoatenanoparticle

6、agglomerates (10 mg) is administered by intratracheal insufflation using a dry powder insufflator.At the end of the experiment, the rats are euthanized by isoflurane inhalation overdose followed by harvest ofmajor organs 1.MCE has not independently confirmed the accuracy of these methods. They are for reference only.REFERENCES1. El-Gendy N, et al. Dry powdered aerosols of diatrizoic acid nanoparticle agglomerates as a lung contrast agent. Int J Pharm. 2010 May31;391(1-2):305-12.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use onl