Neuropeptide-Y-Receptor-Agonists-Modulators-生命科學(xué)試劑-MedChemExpress

1、 HYPERLINK https:/www.MedChemE/Targets/Neuropeptide Y Receptor.html Neuropeptide HYPERLINK https:/www.MedChemE/Targets/Neuropeptide Y Receptor.html HYPERLINK https:/www.MedChemE/Targets/Neuropeptide Y Receptor.html Y HYPERLINK https:/www.MedChemE/Targets/Neuropeptide Y Receptor.html HYPERLINK https:

2、/www.MedChemE/Targets/Neuropeptide Y Receptor.html ReceptorNPY receptorNeuropeptide Y receptors belong G protein-coupled receptor superfamily and comprise various subtypes. There are currently fivecloned NPY receptor subtypes in mammals, termed Y1, Y2, Y4, Y5, and Y6. Neuropeptide Y receptors mediat

3、e a variety ofphysiological responses including feeding and vasoconstriction.Subtypes Y1, Y2, Y4 and Y5 are expressed in humans. They are present mainly in the central and peripheral nervous systems as wellas other tissues, such as the cardiovascular system. Their physiologic ligands are the neurotr

4、ansmitter Neuropeptide Y and the 2hormones peptide YY (PYY) and pancreatic polypeptide (PP).Neuropeptide Y and its receptors regulate important biological and pathophysiological functions, such as blood pressure,neuroendocrine secretions, seizures, neuronal excitability and neuroplasticity.www.MedCh

5、emE 1 HYPERLINK https:/www.MedChemE/Targets/Neuropeptide Y Receptor.html Neuropeptide HYPERLINK https:/www.MedChemE/Targets/Neuropeptide Y Receptor.html HYPERLINK https:/www.MedChemE/Targets/Neuropeptide Y Receptor.html Y HYPERLINK https:/www.MedChemE/Targets/Neuropeptide Y Receptor.html HYPERLINK h

6、ttps:/www.MedChemE/Targets/Neuropeptide Y Receptor.html Receptor HYPERLINK https:/www.MedChemE/Targets/Neuropeptide Y Receptor.html HYPERLINK https:/www.MedChemE/Targets/Neuropeptide Y Receptor.html Agonists, HYPERLINK https:/www.MedChemE/Targets/Neuropeptide Y Receptor.html HYPERLINK https:/www.Med

7、ChemE/Targets/Neuropeptide Y Receptor.html Antagonists, HYPERLINK https:/www.MedChemE/Targets/Neuropeptide Y Receptor.html HYPERLINK https:/www.MedChemE/Targets/Neuropeptide Y Receptor.html Inhibitors HYPERLINK https:/www.MedChemE/Targets/Neuropeptide Y Receptor.html HYPERLINK https:/www.MedChemE/Ta

8、rgets/Neuropeptide Y Receptor.html & HYPERLINK https:/www.MedChemE/Targets/Neuropeptide Y Receptor.html HYPERLINK https:/www.MedChemE/Targets/Neuropeptide Y Receptor.html Modulators HYPERLINK https:/www.MedChemE/r-jnj-31020028.html (R)-JNJ-31020028 HYPERLINK https:/www.MedChemE/r-jnj-31020028.html H

9、YPERLINK https:/www.MedChemE/bibo3304-tfa.html BIBO3304 HYPERLINK https:/www.MedChemE/bibo3304-tfa.html HYPERLINK https:/www.MedChemE/bibo3304-tfa.html TFACat. No.: HY-107479 Cat. No.: HY-107725(R)-JNJ-31020028 is a high affinity, selectivebrain penetrant neuropeptide Y Y2 receptorantagonist, with p

10、IC values of 8.07, 8.22 and8.21 for human, rat, and mouse Y2 receptor,respectively.BIBO3304 TFA is a potent, orally active, andselective neuropeptide Y (NPY) Y1 receptorantagonist, with subnanomolar affinity for boththe human and the rat Y1 receptor (IC =0.38 and0.72 nM, respectively).Purity: 98%Cli

11、nical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 99.95%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg, 50 mg HYPERLINK https:/www.MedChemE/bibp3226.html BIBP3226 HYPERLINK https:/www.MedChemE/bibp3226.html HYPERLINK https:/www.MedChemE/bibp3226-tfa.html BIBP3226 HYPERLINK h

12、ttps:/www.MedChemE/bibp3226-tfa.html HYPERLINK https:/www.MedChemE/bibp3226-tfa.html TFACat. No.: HY-107726A Cat. No.: HY-107726BIBP3226 is a potent and selective neuropeptide YY1 (NPY Y1) and neuropeptide FF (NPFF)receptor antagonist, with Ks of 1.1, 79, and 108nM for rNPY Y1, hNPFF2, and rNPFF, re

13、spectively.BIBP3226 displays anxiogenic-like effect.BIBP3226 TFA is a potent and selectiveneuropeptide Y Y1 (NPY Y1) and neuropeptide FF(NPFF) receptor antagonist, with Ks of 1.1, 79,and 108 nM for rNPY Y1, hNPFF2, and rNPFF,respectively. BIBP3226 TFA displaysanxiogenic-like effect.Purity: 98%Clinic

14、al Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98.09%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 25 mg HYPERLINK https:/www.MedChemE/BIIE-0246.html BIIE-0246(AR-H 053591) Cat. No.: HY-101986 HYPERLINK https:/www.MedChemE/bms-193885.html BMS-193885Cat. No.: HY-120619

15、BIIE-0246 is a potent and highly selectivenon-peptide neuropeptide Y (NPY) Y receptorantagonist, with an IC of 15 nM.Purity: 99.0%Clinical Data: No Development ReportedSize: 1 mgBMS-193885 is a potent, selective, competitive,and brain penetrant neuropeptide Y receptorantagonist with a Ki of 3.3 nM,

16、and has an IC of5.9 nM for hY , which displays 100, 160, 160 and 160-fold selectivity over , hY , hY and hY receptors, respectively .Purity: 99.08%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg HYPERLINK https:/www.MedChemE/cart-55-102-human-tfa.html CART(55-102)(human) HYPERLIN

17、K https:/www.MedChemE/cart-55-102-human-tfa.html HYPERLINK https:/www.MedChemE/cart-55-102-human-tfa.html TFA HYPERLINK https:/www.MedChemE/cart-55-102-human-tfa.html HYPERLINK https:/www.MedChemE/cart-55-102-rat-tfa.html CART(55-102)(rat) HYPERLINK https:/www.MedChemE/cart-55-102-rat-tfa.html HYPER

18、LINK https:/www.MedChemE/cart-55-102-rat-tfa.html TFACat. No.: HY-P1304A Cat. No.: HY-P1305ACART(55-102)(human) TFA is a human satiety factorwith potent appetite-suppressing activity.CART(55-102)(human) TFA is closely associated withleptin and neuropeptide Y.CART(55-102)(rat) TFA is a rat satiety fa

19、ctor withpotent appetite-suppressing activity.CART(55-102)(rat) TFA is closely associated withleptin and neuropeptide Y. CART(55-102)(rat) TFAcan induces anxiety and stress-related behavior.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development Repo

20、rtedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/CGP71683_hydrochloride.html CGP71683 HYPERLINK https:/www.MedChemE/CGP71683_hydrochloride.html HYPERLINK https:/www.MedChemE/CGP71683_hydrochloride.html hydrochloride HYPERLINK https:/www.MedChemE/CGP71683_hydrochloride.html HYPERLINK https:/www.Med

21、ChemE/cym-9484.html CYM HYPERLINK https:/www.MedChemE/cym-9484.html HYPERLINK https:/www.MedChemE/cym-9484.html 9484(CGP71683A) Cat. No.: HY-107723Cat. No.: HY-107735CGP71683 hydrochloride is a competitiveneuropeptide Y5 receptor antagonist with a K of1.3 nM, and shows no obvious activity at Y1recep

22、tor (K, 4000 nM) and Y2 receptor ( ,Ki200 nM) in cell membranes.CYM 9484 is a selective and highly potentneuropeptide Y (NPY) Y2 receptor antagonist withan IC value of 19 nM.Purity: 99.12%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mgPurity: 99.0%Clinical Data: No

23、 Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg2 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/cym2503.html CYM2503 HYPERLINK https:/www.MedChemE/cym2503.html HYPERLINK https:/www.MedChemE/Benzo3,4cyclohept1,2-dimidazole,_1,4,5,6-tetrahydro-9-methyl-2-_3-p

24、yridinyl_-.html FR252384Cat. No.: HY-123671 Cat. No.: HY-U00335CYM2503 is a putative GalR2-positive allostericmodulator. CYM2503 increases the latency to firstelectrographic seizure and decreases the totaltime in seizure. CYM2503 also attenuateselectroshock-induced seizures in mice.FR252384 is a neu

25、ropeptide Y-Y5 receptorantagonist, with an IC of 2.3 nM.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/Galanin_1-16_,_mouse,_porcine,_rat.html Galanin HYPERLINK https:/www.MedChemE/Galan

26、in_1-16_,_mouse,_porcine,_rat.html HYPERLINK https:/www.MedChemE/Galanin_1-16_,_mouse,_porcine,_rat.html (1-16), HYPERLINK https:/www.MedChemE/Galanin_1-16_,_mouse,_porcine,_rat.html HYPERLINK https:/www.MedChemE/Galanin_1-16_,_mouse,_porcine,_rat.html mouse, HYPERLINK https:/www.MedChemE/Galanin_1-

27、16_,_mouse,_porcine,_rat.html HYPERLINK https:/www.MedChemE/Galanin_1-16_,_mouse,_porcine,_rat.html porcine, HYPERLINK https:/www.MedChemE/Galanin_1-16_,_mouse,_porcine,_rat.html HYPERLINK https:/www.MedChemE/Galanin_1-16_,_mouse,_porcine,_rat.html rat HYPERLINK https:/www.MedChemE/Galanin_1-16_,_mo

28、use,_porcine,_rat.html HYPERLINK https:/www.MedChemE/Galanin_1-16_,_mouse,_porcine,_rat_TFA.html Galanin HYPERLINK https:/www.MedChemE/Galanin_1-16_,_mouse,_porcine,_rat_TFA.html HYPERLINK https:/www.MedChemE/Galanin_1-16_,_mouse,_porcine,_rat_TFA.html (1-16), HYPERLINK https:/www.MedChemE/Galanin_1

29、-16_,_mouse,_porcine,_rat_TFA.html HYPERLINK https:/www.MedChemE/Galanin_1-16_,_mouse,_porcine,_rat_TFA.html mouse, HYPERLINK https:/www.MedChemE/Galanin_1-16_,_mouse,_porcine,_rat_TFA.html HYPERLINK https:/www.MedChemE/Galanin_1-16_,_mouse,_porcine,_rat_TFA.html porcine, HYPERLINK https:/www.MedChe

30、mE/Galanin_1-16_,_mouse,_porcine,_rat_TFA.html HYPERLINK https:/www.MedChemE/Galanin_1-16_,_mouse,_porcine,_rat_TFA.html rat HYPERLINK https:/www.MedChemE/Galanin_1-16_,_mouse,_porcine,_rat_TFA.html HYPERLINK https:/www.MedChemE/Galanin_1-16_,_mouse,_porcine,_rat_TFA.html TFACat. No.: HY-P1578 Cat.

31、No.: HY-P1578AGalanin (1-16), mouse, porcine, rat is an agonistof the hippocampal galanin receptor, with a Kof 3 nM.Galanin (1-16), mouse, porcine, rat (TFA) is anagonist of the hippocampal galanin receptor, witha K of 3 nM.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 99.

32、39%Clinical Data: No Development ReportedSize: 500 g, 1 mg, 5 mg HYPERLINK https:/www.MedChemE/galanin-1-29-rat-mouse.html Galanin HYPERLINK https:/www.MedChemE/galanin-1-29-rat-mouse.html HYPERLINK https:/www.MedChemE/galanin-1-29-rat-mouse.html (1-29)(rat, HYPERLINK https:/www.MedChemE/galanin-1-2

33、9-rat-mouse.html HYPERLINK https:/www.MedChemE/galanin-1-29-rat-mouse.html mouse) HYPERLINK https:/www.MedChemE/galanin-1-29-rat-mouse.html HYPERLINK https:/www.MedChemE/galanin-1-29-rat-mouse-tfa.html Galanin HYPERLINK https:/www.MedChemE/galanin-1-29-rat-mouse-tfa.html HYPERLINK https:/www.MedChem

34、E/galanin-1-29-rat-mouse-tfa.html (1-29)(rat, HYPERLINK https:/www.MedChemE/galanin-1-29-rat-mouse-tfa.html HYPERLINK https:/www.MedChemE/galanin-1-29-rat-mouse-tfa.html mouse) HYPERLINK https:/www.MedChemE/galanin-1-29-rat-mouse-tfa.html HYPERLINK https:/www.MedChemE/galanin-1-29-rat-mouse-tfa.html

35、 TFACat. No.: HY-P1132 Cat. No.: HY-P1132AGalanin (1-29)(rat, mouse) is a non-selectivegalanin receptor agonist, with Ks of 0.98, 1.48and 1.47 nM for GAL1, GAL2 and GAL3 respectively.Anticonvulsant effect.Galanin (1-29)(rat, mouse) TFA is a non-selectivegalanin receptor agonist, with Ks of 0.98, 1.4

36、8and 1.47 nM for GAL1, GAL2 and GAL3, respectively.Anticonvulsant effect.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/Galanin_1-30_,_human.html Galanin HYPERLINK https:/www.MedChemE/Ga

37、lanin_1-30_,_human.html HYPERLINK https:/www.MedChemE/Galanin_1-30_,_human.html (1-30), HYPERLINK https:/www.MedChemE/Galanin_1-30_,_human.html HYPERLINK https:/www.MedChemE/Galanin_1-30_,_human.html human HYPERLINK https:/www.MedChemE/Galanin_1-30_,_human.html HYPERLINK https:/www.MedChemE/galanin-

38、receptor-ligand-m35.html Galanin HYPERLINK https:/www.MedChemE/galanin-receptor-ligand-m35.html HYPERLINK https:/www.MedChemE/galanin-receptor-ligand-m35.html Receptor HYPERLINK https:/www.MedChemE/galanin-receptor-ligand-m35.html HYPERLINK https:/www.MedChemE/galanin-receptor-ligand-m35.html Ligand

39、 HYPERLINK https:/www.MedChemE/galanin-receptor-ligand-m35.html HYPERLINK https:/www.MedChemE/galanin-receptor-ligand-m35.html M35Cat. No.: HY-P1127 Cat. No.: HY-P1840Galanin (1-30), human is a 30-amino acidneuropeptide, and acts as an agonist of GalR1 andGalR2 receptors, with Ks of both 1 nM.Galani

40、n Receptor Ligand M35 is a high-affinityligand and antagonist of galanin receptor(K =0.1 nM). Galanin Receptor Ligand M35 exertsa K values of 0.11 and 2.0 nM for human galaninreceptor type 1 and 2, respectively.Purity: 99.11%Clinical Data: No Development ReportedSize: 500 g, 1 mg, 5 mgPurity: 99.65%

41、Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mg HYPERLINK https:/www.MedChemE/galanin-receptor-ligand-m35-tfa.html Galanin HYPERLINK https:/www.MedChemE/galanin-receptor-ligand-m35-tfa.html HYPERLINK https:/www.MedChemE/galanin-receptor-ligand-m35-tfa.html Receptor HYPERLINK https:/www

42、.MedChemE/galanin-receptor-ligand-m35-tfa.html HYPERLINK https:/www.MedChemE/galanin-receptor-ligand-m35-tfa.html Ligand HYPERLINK https:/www.MedChemE/galanin-receptor-ligand-m35-tfa.html HYPERLINK https:/www.MedChemE/galanin-receptor-ligand-m35-tfa.html M35 HYPERLINK https:/www.MedChemE/galanin-rec

43、eptor-ligand-m35-tfa.html HYPERLINK https:/www.MedChemE/galanin-receptor-ligand-m35-tfa.html TFA HYPERLINK https:/www.MedChemE/galanin-receptor-ligand-m35-tfa.html HYPERLINK https:/www.MedChemE/Galantide.html GalantideCat. No.: HY-P1840A Cat. No.: HY-P0262Galanin Receptor Ligand M35 TFA is a high-af

44、finityligand and antagonist of galanin receptor (K =0.1nM). Galanin Receptor Ligand M35 TFA exerts a Kvalues of 0.11 and 2.0 nM for human galaninreceptor type 1 and 2, respectively.Galantide, a non-specific galanin receptorantagonist, is a peptide consisting of fragmentsof galanin and substance P. G

45、alantide recognizestwo classes of galanin binding sites (K 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 99.27%Clinical Data: No Development ReportedSize: 500 g, 1 mg, 5 mgwww.MedChemE 3 HYPERLINK https:/www.MedChemE/galnon.html GalnonCat. No.: HY-103536 HYPERLINK https:/www.MedCh

46、emE/gr231118.html GR231118(1229U91; GW1229) Cat. No.: HY-P1321Galnon is a selective and non-peptide agonist ofgalanin GAL1 and GAL2 receptor, with Ks of 11.7and 34.1 M respectively. Galnon exhibitsanticonvulsant and anxiolytic effects.GR231118, an analogue of the C-terminus ofneuropeptide Y, is a po

47、tent , competitive andrelative seletive antagonist at human neuropeptideY Y receptor with a pK of 10.4.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/gr231118-tfa.html GR231118 HYPERLINK

48、 https:/www.MedChemE/gr231118-tfa.html HYPERLINK https:/www.MedChemE/gr231118-tfa.html TFA(1229U91 TFA; GW1229 TFA) Cat. No.: HY-P1321A HYPERLINK https:/www.MedChemE/HT-2157.html HT-2157(SNAP 37889) Cat. No.: HY-100717GR231118 TFA, an analogue of the C-terminus ofneuropeptide Y, is a potent , compet

49、itive andrelative seletive antagonist at human neuropeptideYY receptor with a pK of 10.4.HT-2157 (SNAP 37889) is a selective,high-affinity, competitive antagonists of galanin-3receptor (Gal ).Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98.0%Clinical Data: Phase 2Size: 10

50、 mM 1 mL, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/JNJ-31020028.html JNJ-31020028 HYPERLINK https:/www.MedChemE/JNJ-31020028.html HYPERLINK https:/www.MedChemE/jnj-5207787.html JNJ-5207787Cat. No.: HY-14450 Cat. No.: HY-107732JNJ-31020028 is a selective brain penetrantantagonis

51、t of neuropeptide Y2 receptor with highaffinity (pIC50=8.07, human; pIC50=8.22 rat);100-fold selective versus human Y1/Y4/Y5receptors.Purity: 98.62%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mgJNJ-5207787 is a nonpeptidic, selective andpenetrate the blood-brain b

52、arrier neuropeptide YY receptor (Y ) antagonist. JNJ-5207787inhibits the binding of peptide YY (PYY) withpIC s of 7.0 and 7.1 for human Y receptor andrat Y receptor, respectively.Purity: 98.0%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/l-152804.html L HYPERLI

53、NK https:/www.MedChemE/l-152804.html HYPERLINK https:/www.MedChemE/l-152804.html 152804 HYPERLINK https:/www.MedChemE/l-152804.html HYPERLINK https:/www.MedChemE/lu-aa33810.html Lu HYPERLINK https:/www.MedChemE/lu-aa33810.html HYPERLINK https:/www.MedChemE/lu-aa33810.html AA33810Cat. No.: HY-107734

54、Cat. No.: HY-107729L 152804 is an orally active and selectiveneuropeptide Y Y5 receptor (NPY5-R) antagonist,with a K of 26 nM for . L 152804 causeshY5weight loss in diet-induced obese mice bymodulating food intake and energy expenditure.Lu AA33810 is a potent and selective antagonist ofneuropeptide

55、Y5 receptor with a K of 1.5 nM forthe human receptor. Lu AA33810 exhibtsantianxiolytic-like and antidepressant-likeeffects.Purity: 99.73%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https

56、:/www.MedChemE/m1145.html M1145 HYPERLINK https:/www.MedChemE/m1145.html HYPERLINK https:/www.MedChemE/m1145-tfa.html M1145 HYPERLINK https:/www.MedChemE/m1145-tfa.html HYPERLINK https:/www.MedChemE/m1145-tfa.html TFACat. No.: HY-P1135 Cat. No.: HY-P1135AM1145, a chimeric peptide, is a selective gal

57、aninreceptor type 2 (GAL2) agonist, with a K of 6.55nM. M1145 shows more than 90-fold higher affinityfor GAL2 over GAL1 (K=587 nM) and a 76-fold higheraffinity over GalR3 (K=497nM).M1145 TFA, a chimeric peptide, is a selectivegalanin receptor type 2 (GAL2) agonist, with a Kof 6.55 nM. M1145 TFA show

58、s more than 90-foldhigher affinity for GAL2 over GAL1 (K=587 nM) anda 76-fold higher affinity over GalR3 (K=497nM).Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg4 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedCh

59、emE HYPERLINK https:/www.MedChemE/M40.html M40 HYPERLINK https:/www.MedChemE/M40.html HYPERLINK https:/www.MedChemE/m617.html M617Cat. No.: HY-P1025 Cat. No.: HY-P1131M40 is a potent, non-selective galanin receptorantagonist.M617 is a selective galanin receptor 1 (GAL1)agonist, with Ks of 0.23 and 5

60、.71 nM for GAL1 andGAL2, respectively. M617, acting through itscentral GAL1, can promote GLUT4 expression andenhance GLUT4 content in the cardiac muscle oftype 2 diabetic rats.Purity: 98%Clinical Data: No Development ReportedSize: 500 g, 1 mg, 5 mg, 10 mgPurity: 98%Clinical Data: No Development Repo