Adenosine-amine-congener-ADAC-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAdenosine amine congenerCat. No.: HY-128064CAS No.: 96760-69-9Synonyms: ADAC分式: CHNO分量: 576.6作靶點(diǎn): Adenosine Receptor作通路: GPCR/G Protein儲(chǔ)存式: Please store the product under the recommended conditions inthe COA.溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 31.

2、25 mg/mL (54.20 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 1.7343 mL 8.6715 mL 17.3430 mL5 mM 0.3469 mL 1.7343 mL 3.4686 mL10 mM 0.1734 mL 0.8672 mL 1.7343 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍福渲魄罢?qǐng)先配制澄的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建

3、議您現(xiàn)現(xiàn)配，當(dāng)天使；澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (3.61 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (3.61 mM); Clear solution3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubilit

4、y: 2.08 mg/mL (3.61 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 Adenosine amine congener (ADAC)種選擇性的 A1 腺苷受體 (A1 adenosine receptor) 激動(dòng)劑，可以改善噪和鉑引起的蝸損傷。Adenosine amine congener 還具有神經(jīng)保護(hù)作。IC50 & Target A1 adenosine receptor 1 2體外研究 Adenosine amine congener

5、 can reduce oxidative stress in the noise-exposed cochlea, leading to protectionof sensory hair cells. Adenosine amine congener also can reduce cisplatin-induced apoptosis in cochleartissues, particularly in sensory hair cells and strial marginal cells. The mechanisms of otoprotection byAdenosine am

6、ine congener include inhibition of glutamate release via presynaptic A1 receptors and inhibitionof voltage-gated Ca2+ channels, which can prevent activation of apoptotic and necrotic cell death pathways1.體內(nèi)研究 Adenosine amine congener (25-300g/kg/day; intraperitoneal injection; daily; for 5 days; mal

7、e Wistar rats)treatment is most effective in the first 24 hours after noise exposure at doses 50g/kg, providing up to 21dB protection. Adenosine amine congener mitigates noise-induced hearing loss in a dose- and time-dependent manner 1.Animal Model: Male Wistar rats (8-10 weeks old) treated with noi

8、se exposure 1Dosage: 25 g/kg/day, 50 g/kg/day, 100 g/kg/day, 200 g/kg/day, and 300g/kg/dayAdministration: Intraperitoneal injection; daily; for 5 daysResult: Most effective in the first 24 hours after noise exposure at doses 50g/kg, and providedup to 21dB protection (averaged across 8-28kHz).REFEREN

9、CES1. Vlajkovic SM, et al. Adenosine amine congener as a cochlear rescue agent. Biomed Res Int. 2014;2014:841489.2. Vlajkovic SM, et al. Adenosine amine congener mitigates noise-induced cochlear injury. Purinergic Signal. 2010 Jun;6(2):273-81.McePdfHeightCaution: Product has not been fully validated for medical