Fmoc-3VVD-OH-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemEFmoc-3VVD-OHCat.No.:HY-78921CASNo.:863971-44-2分?式:C??H??N?O?分?量:637.81作?靶點:ADCLinker作?通路:Antibody-drugConjugate/ADCRelated儲存?式:4°C,storedundernitrogen*Insolvent:-80°C,6months;-20°C,1month(storedunder

nitrogen)溶解性數(shù)據(jù)體外實驗DMSO:≥37mg/mL(58.01mM)H2O:<0.1mg/mL(insoluble)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制備儲備液1mM1.5679mL7.8393mL15.6787mL5mM0.3136mL1.5679mL3.1357mL10mM0.1568mL0.7839mL1.5679mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存?式和期限。體內(nèi)實驗請根據(jù)您的實驗動物和給藥?式選擇適當?shù)娜芙?案，配制前請先配制澄的儲備液，再依次添加助溶劑(為保證實驗結(jié)果的可靠性，體內(nèi)實驗的?作液，建議您現(xiàn)?現(xiàn)配，當天使?；澄的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分?指該溶劑在您配制終溶液中的體積占?)：1.請依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥5mg/mL(7.84mM);ClearsolutionBIOLOGICALACTIVITY1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemE?物活性Fmoc-3VVD-OH?種可降解(non-cleavable)的ADC連接橋，?于抗體藥物結(jié)合物(ADCs)的合成。IC50&TargetCleavable體外研究ADCsarecomprisedofanantibodytowhichisattachedanADCcytotoxinthroughanADClinker.REFERENCES[1].MichinoriAkaiwa,etal.SynthesisandEvaluationofLinearandMacrocyclicDolastatin10AnaloguesContainingPyrrolidineRingModifications.ACSOmega.2018May31;3(5):5212-5221.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax: