SRI-011381-hydrochloride-DataSheet-生命科學試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemESRI-011381hydrochlorideCat.No.:HY-100347ACASNo.:2070014-88-7分?式:C??H??ClN?O分?量:365.94作?靶點:TGF-beta/Smad作?通路:StemCell/Wnt;TGF-beta/Smad儲存?式:4°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性數(shù)據(jù)體外實驗DMSO:33.33mg/mL(91.08mM;Needultrasonic)H2O:25mg/mL(68.32mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM2.7327mL13.6634mL27.3269mL5mM0.5465mL2.7327mL5.4654mL10mM0.2733mL1.3663mL2.7327mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。體內(nèi)實驗請根據(jù)您的實驗動物和給藥?式選擇適當?shù)娜芙?案。以下溶解?案都請先按照InVitro?式配制澄的儲備液，再依次添加助溶劑：(為保證實驗結(jié)果的可靠性，澄的儲備液可以根據(jù)儲存條件，適當保存；體內(nèi)實驗的?作液，建議您現(xiàn)?現(xiàn)配，當天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.5mg/mL(6.83mM);Clearsolution2.請依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)1/3MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemESolubility:≥2.5mg/mL(6.83mM);Clearsolution3.請依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(6.83mM);Clearsolution4.請依序添加每種溶劑：PBSSolubility:50mg/mL(136.63mM);Clearsolution;NeedultrasonicBIOLOGICALACTIVITY?物活性SRI-011381hydrochloride?種有具有?服?物活性的TGF-β信號通路的激活劑，具有神經(jīng)保護作?[1]。IC50&TargetTGF-beta[1]體外研究SRI-011381(10μM)hydrochloridepromotestheproliferationofmouselungfibroblasts,andsignificantlyincreasesTGF-β1,NALP3,collagen-1,andα-SMAexpression[1].體內(nèi)研究SRI-011381(30mg/kg;i.p.;every2d;for22days)hydrochloridepartiallyrescuesthedeficitsinopticnerveandretinaofYAPGFAP-CKOEAEmice[2].AnimalModel:YAPGFAP-CKOmicebearingexperimentalautoimmuneencephalomyelitis(EAE)[2]Dosage:30mg/kgAdministration:Intraperitoneallyinjection;every2d;for22daysResult:SignificantlyinhibitedinflammatoryinfiltrationandrelievedthelossofneuronsinYAPGFAP-CKOEAEmice.戶使?本產(chǎn)品發(fā)表的科研?獻?Theranostics.2021;11(17):8480-8499.?LifeSci.2021Aug15;279:119359.?Phytomedicine.1June2022,154234.?Phytomedicine.2022Mar21;100:154067.?CancerCellInt.2022May16;22(1):191.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].JingyinHan,etal.TheImprovementEffectofSodiumFerulateontheFormationofPulmonaryFibrosisinSilicosisMiceThroughtheNeutrophilAlkalinePhosphatase3(NALP3)/TransformingGrowthFactor-β1(TGF-β1)/α-SmoothMuscleActin(α-SMA)Pathway.Med[2].QianWu,etal.AstrocyticYAPprotectstheopticnerveandretinainanexperimentalautoimmuneencephalomyelitismodelthroughTGF-βsignaling.Theranostics.2021Jul25;11(17):8480-8499.2/3MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEMcePdfHeightCaution:Producthasnotbeenfullyvalidatedformed