4-Hydroxymephenytoin-D3-DataSheet-生命科學試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemE4-HydroxymephenytoinD3Cat.No.:HY-W008772SCASNo.:1173022-56-4分?式:C??H??D?N?O?分?量:237.27作?靶點:DrugMetabolite作?通路:MetabolicEnzyme/Protease儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實驗DMSO:100mg/mL(421.46mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM4.2146mL21.0730mL42.1461mL5mM0.8429mL4.2146mL8.4292mL10mM0.4215mL2.1073mL4.2146mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。BIOLOGICALACTIVITY?物活性4-HydroxymephenytoinD34-Hydroxymephenytoin的氘代物。4-Hydroxymephenytoin抗癲癇藥mephenytoin的代謝物;mephenytoin為CYP2C19的?種配體。體外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs[1].REFERENCES[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-216.[2].TanakaM,etal.Simpleandselectiveassayof4-hydroxymephenytoininhumanurineusingsolid-phaseextractionandhigh-performanceliquidchromatographywithelectrochemicaldetectionanditspreliminaryapplicationtophenotypingtest.JChromatogrBBiomedAppl.1996Feb9;676(1):87-94.[3].StewartNA,etal.AUPLC-MS/MSassayofthe"Pittsburghcocktail":sixCYPprobe-drug/metabolitesfromhumanplasmaandurineusingstableisotopedilution.Analyst.2011Feb7;136(3):605-12.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-379