TCS7010-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemETCS7010Cat.No.:HY-70061CASNo.:1158838-45-9分?式:C??H??ClFN?O?分?量:588.08作?靶點(diǎn):AuroraKinase;Apoptosis作?通路:CellCycle/DNADamage;Epigenetics;Apoptosis儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:50mg/mL(85.02mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM1.7004mL8.5022mL17.0045mL5mM0.3401mL1.7004mL3.4009mL10mM0.1700mL0.8502mL1.7004mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請(qǐng)先按照InVitro?式配制澄的儲(chǔ)備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請(qǐng)依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(4.25mM);Clearsolution1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEBIOLOGICALACTIVITY?物活性TCS7010有效，?度選擇的AuroraA抑制劑，IC50值為3.4nM。IC50&TargetAuroraAAuroraB3.4nM(IC50)3.4μM(IC50)體外研究TCS7010isexceptionallyselectiveAuroraAinhibitors.TCS7010isanusefultoolcompoundsforinvestigatingthecellularroleofAuroraAkinaseswithoutthecomplicationofalsoinhibitingAuroraB[1].戶使?本產(chǎn)品發(fā)表的科研?獻(xiàn)?JBiomolScreen.2013Oct;18(9):1062-71.?HarvardMedicalSchoolLINCSLIBRARYSeemorecustomervalidationsonwww.MedChemEREFERENCES[1].Aliagas-MartinI,BurdickD,CorsonL,DotsonJ,DrummondJ,FieldsC,HuangOW,HunsakerT,KleinheinzT,KruegerE,LiangJ,MoffatJ,PhillipsG,PulkR,RawsonTE,UltschM,WalkerL,WiesmannC,ZhangB,ZhuBY,CochranAG.Aclassof2,4-bisanilinopyMcePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;