版權(quán)說明:本文檔由用戶提供并上傳,收益歸屬內(nèi)容提供方,若內(nèi)容存在侵權(quán),請進行舉報或認領(lǐng)
文檔簡介
益氣活血化痰方對氣虛痰瘀型不穩(wěn)定型心絞痛PCI術(shù)后患者LP-PLA2和IL-10的影響及生存質(zhì)量研究摘要:目的:探討益氣活血化痰方對氣虛痰瘀型不穩(wěn)定型心絞痛PCI術(shù)后患者LP-PLA2和IL-10的影響及生存質(zhì)量研究。方法:選取2017年1月至2019年7月在我院行PCI手術(shù)的患者,根據(jù)病情分為兩組,分別為益氣活血化痰方組和對照組,每組100例。益氣活血化痰方組在基礎(chǔ)治療的基礎(chǔ)上加用益氣活血化痰方,對照組僅進行基礎(chǔ)治療。兩組均在手術(shù)后1、3、6個月進行LP-PLA2和IL-10檢測,并評估生存質(zhì)量。結(jié)果:益氣活血化痰方組與對照組比較,手術(shù)后1、3、6個月,益氣活血化痰方組LP-PLA2水平明顯低于對照組,差異有統(tǒng)計學意義(P<0.05)。益氣活血化痰方組IL-10水平明顯高于對照組,差異有統(tǒng)計學意義(P<0.05)。益氣活血化痰方組生存質(zhì)量評分明顯高于對照組,差異有統(tǒng)計學意義(P<0.05)。結(jié)論:益氣活血化痰方可以顯著降低氣虛痰瘀型不穩(wěn)定型心絞痛PCI術(shù)后患者LP-PLA2的水平,提高IL-10的水平,改善患者的生存質(zhì)量。
關(guān)鍵詞:氣虛痰瘀型;不穩(wěn)定型心絞痛;PCI;益氣活血化痰方;LP-PLA2;IL-10;生存質(zhì)量
EffectofYiqiHuoxueHuatanFangonLP-PLA2andIL-10inpatientswithunstableanginapectorisofQi-deficiency-Phlegm-stasistypeafterPCIandstudyonqualityoflife.
Abstract:Objective:ToinvestigatetheeffectofYiqiHuoxueHuatanFangonLP-PLA2andIL-10inpatientswithunstableanginapectorisofQi-deficiency-Phlegm-stasistypeafterPCIandstudyonthequalityoflife.Methods:200patientswhounderwentPCIsurgeryfromJanuary2017toJuly2019wereselectedanddividedintotwogroupsaccordingtothecondition,YiqiHuoxueHuatanFanggroupandcontrolgroup,with100casesineachgroup.YiqiHuoxueHuatanFangwasaddedtothebasictreatmentintheYiqiHuoxueHuatanFanggroup,whilethecontrolgrouponlyreceivedbasictreatment.LP-PLA2andIL-10weredetectedat1,3,and6monthsaftersurgeryinbothgroups,andthequalityoflifewasevaluated.Results:Comparedwiththecontrolgroup,theLP-PLA2levelintheYiqiHuoxueHuatanFanggroupwassignificantlylowerthanthatinthecontrolgroupat1,3,and6monthsaftersurgery,withstatisticallysignificantdifferences(P<0.05).TheIL-10levelintheYiqiHuoxueHuatanFanggroupwassignificantlyhigherthanthatinthecontrolgroup,withstatisticallysignificantdifferences(P<0.05).ThequalityoflifescoreintheYiqiHuoxueHuatanFanggroupwassignificantlyhigherthanthatinthecontrolgroup,withstatisticallysignificantdifferences(P<0.05).Conclusion:YiqiHuoxueHuatanFangcansignificantlyreducethelevelofLP-PLA2inpatientswithunstableanginapectorisofQi-deficiency-Phlegm-stasistypeafterPCI,increasethelevelofIL-10,andimprovethequalityoflifeofpatients.
Keywords:Qi-deficiency-Phlegm-stasistype;unstableanginapectoris;PCI;YiqiHuoxueHuatanFang;LP-PLA2;IL-10;qualityoflif5.Discussion
Inthisstudy,weinvestigatedtheeffectofYiqiHuoxueHuatanFangonLP-PLA2andIL-10levelsinpatientswithunstableanginapectorisofQi-deficiency-Phlegm-stasistypeafterPCI,aswellastheirqualityoflife.TheresultsshowedthatYiqiHuoxueHuatanFangcansignificantlyreducethelevelofLP-PLA2,increasethelevelofIL-10,andimprovethequalityoflifeofpatients.
LP-PLA2isanenzymethatismainlyproducedbymacrophagesandisinvolvedintheinflammatoryprocessofatherosclerosis.Itcanhydrolyzeoxidizedlow-densitylipoprotein(ox-LDL)andgenerateproductsthatpromoteinflammatoryreactions,leadingtotheformationofunstableplaquesandsubsequentacutecardiovascularevents(20,21).StudieshaveshownthatthelevelofLP-PLA2issignificantlyhigherinpatientswithunstableanginapectorisandisassociatedwiththeseverityofthedisease(22,23).Therefore,reducingthelevelofLP-PLA2isanimportantstrategyforthepreventionandtreatmentofunstableanginapectoris.
IL-10isananti-inflammatorycytokinethatcaninhibittheproductionofpro-inflammatorycytokinesandreducetheinflammatoryresponseinthebody(24).StudieshaveshownthatIL-10levelsarelowerinpatientswithunstableanginapectorisandareassociatedwiththeprognosisofthedisease(25,26).Therefore,increasingthelevelofIL-10isalsoanimportantstrategyforthetreatmentofunstableanginapectoris.
YiqiHuoxueHuatanFangisatraditionalChinesemedicineformulaconsistingofAstragalusmembranaceus,Salviamiltiorrhiza,Paeonialactiflora,Ligusticumchuanxiong,andBorneolumsyntheticum.Ithasbeenwidelyusedinthetreatmentofcardiovasculardiseases,includingunstableanginapectoris(17,18).ThemainpharmacologicaleffectsofYiqiHuoxueHuatanFangincludepromotingbloodcirculation,removingbloodstasis,andregulatingimmunefunction(19).
Inthisstudy,wefoundthatYiqiHuoxueHuatanFangcansignificantlyreducethelevelofLP-PLA2inpatientswithunstableanginapectorisofQi-deficiency-Phlegm-stasistypeafterPCI.Thismayberelatedtoitsabilitytopromotebloodcirculationandremovebloodstasis,whichcanreducetheformationandruptureofunstableplaques.Inaddition,YiqiHuoxueHuatanFangcanincreasethelevelofIL-10,whichmayberelatedtoitsabilitytoregulateimmunefunctionandinhibittheinflammatoryresponseinthebody.
Furthermore,wefoundthatYiqiHuoxueHuatanFangcanimprovethequalityoflifeofpatientswithunstableanginapectorisofQi-deficiency-Phlegm-stasistypeafterPCI.Thismayberelatedtoitsabilitytopromotebloodcirculation,reducechestpainanddiscomfort,andimprovesleepquality.
Inconclusion,ourstudysuggeststhatYiqiHuoxueHuatanFangcansignificantlyreducethelevelofLP-PLA2,increasethelevelofIL-10,andimprovethequalityoflifeofpatientswithunstableanginapectorisofQi-deficiency-Phlegm-stasistypeafterPCI.However,therearesomelimitationstoourstudy,suchasthesmallsamplesizeandshortfollow-upperiod.Therefore,furtherstudieswithlargersamplesizesandlongerfollow-upperiodsareneededtoconfirmourfindingsInadditiontothelimitationsmentionedabove,thereareotherpotentialfactorsthatcouldhaveaffectedtheoutcomesofourstudy.Forexample,theparticipants’adherencetotheYiqiHuoxueHuatanFangregimenwasnotmonitored,whichcouldhaveinfluencedtheresults.Additionally,theuseofcertainmedicationsbytheparticipantscouldhavehadanimpactontheirLP-PLA2levelsandoverallhealthoutcomes.
Anotherlimitationisthelackofacontrolgroupinourstudy.WhilecomparingtheresultsofourinterventiongroupbeforeandaftertreatmentprovidessomeinsightintotheeffectivenessofYiqiHuoxueHuatanFang,arandomizedcontrolledtrialwithaplacebogroupwouldprovidestrongerevidence.
Despitetheselimitations,ourstudycontributestothegrowingbodyofresearchontheuseoftraditionalChinesemedicineinthetreatmentofunstableanginapectoris.YiqiHuoxueHuatanFangoffersapromisingalternativetoconventionaltreatments,particularlyforpatientsofQi-deficiency-Phlegm-stasistype.FuturestudiesshouldcontinuetoinvestigatetheefficacyandsafetyofthisandothertraditionalChinesemedicineinterventions,inordertoprovidepatientswithadiverserangeoftreatmentoptionsInadditiontoinvestigatingtheeffectivenessoftraditionalChinesemedicineforthetreatmentofunstableanginapectoris,itisalsoimportanttoconsiderthepotentialmechanismsofaction.YiqiHuoxueHuatanFang,forexample,isbelievedtoworkbyimprovingbloodcirculation,resolvingphlegm,andeliminatingstasis.Theseactionsarethoughttohelpreducethefrequencyandseverityofanginaepisodes,aswellasimproveoverallcardiovascularhealth.
However,thereisstillmuchtolearnaboutthespecificmechanismsunderlyingtraditionalChinesemedicineinterventions.Forexample,furtherresearchisneededtobetterunderstandtheroleofacupunctureinthetreatmentofunstableanginapectoris.Whilesomestudieshavesuggestedthatacupuncturecanimprovebloodflowandreduceinflammation,othershavebeeninconclusiveorconflicting.Additionally,thereisaneedformoreresearchonthesafetyoftraditionalChinesemedicine,particularlyinthecontextoflong-termuseorcombinationwithothertreatments.
Ultimately,thegoalofresearchintotraditionalChinesemedicineforthetreatmentofunstableanginapectorisshouldbe
溫馨提示
- 1. 本站所有資源如無特殊說明,都需要本地電腦安裝OFFICE2007和PDF閱讀器。圖紙軟件為CAD,CAXA,PROE,UG,SolidWorks等.壓縮文件請下載最新的WinRAR軟件解壓。
- 2. 本站的文檔不包含任何第三方提供的附件圖紙等,如果需要附件,請聯(lián)系上傳者。文件的所有權(quán)益歸上傳用戶所有。
- 3. 本站RAR壓縮包中若帶圖紙,網(wǎng)頁內(nèi)容里面會有圖紙預(yù)覽,若沒有圖紙預(yù)覽就沒有圖紙。
- 4. 未經(jīng)權(quán)益所有人同意不得將文件中的內(nèi)容挪作商業(yè)或盈利用途。
- 5. 人人文庫網(wǎng)僅提供信息存儲空間,僅對用戶上傳內(nèi)容的表現(xiàn)方式做保護處理,對用戶上傳分享的文檔內(nèi)容本身不做任何修改或編輯,并不能對任何下載內(nèi)容負責。
- 6. 下載文件中如有侵權(quán)或不適當內(nèi)容,請與我們聯(lián)系,我們立即糾正。
- 7. 本站不保證下載資源的準確性、安全性和完整性, 同時也不承擔用戶因使用這些下載資源對自己和他人造成任何形式的傷害或損失。
最新文檔
- 2024年度城市更新項目委托經(jīng)營與管理協(xié)議3篇
- 2024年新型攤位經(jīng)營合作協(xié)議書下載3篇
- 《ICC置管維護》課件
- 2024年智能家居設(shè)備租賃推廣合同范本3篇
- 2024年標準版離婚子女撫養(yǎng)權(quán)變更協(xié)議一
- 《備忘錄的寫作》課件
- 2024年版物業(yè)管理合同標的為商業(yè)物業(yè)
- 2024年版:技術(shù)研發(fā)合作合同書
- 2024年度文化傳播公司員工上下班安全免責協(xié)議3篇
- 2025餐飲公司股東協(xié)議合同
- 2024-2025學年五年級科學上冊第三單元《計量時間》測試卷(教科版)
- 大學生國家安全教育智慧樹知到期末考試答案章節(jié)答案2024年
- 介入科工作總結(jié)
- 四年級上冊道德與法治知識點匯總復(fù)習過程
- 馬克思主義學院工作匯報PPT課件
- QC課題提高檢查井周邊壓實度
- 交接班流程圖
- 工程項目節(jié)能減排策劃案(共61頁)
- 輕鋼龍骨紙面石膏板吊頂施工工藝及方法
- 用人單位職業(yè)病危害項目申報及審核PPT課件
- 淺析科學研究方法論在管理研究中的運用
評論
0/150
提交評論