補(bǔ)腎復(fù)方對(duì)帕金森病患者的療效觀察及血漿磷酸化α-Syn的影響

補(bǔ)腎復(fù)方對(duì)帕金森病患者的療效觀察及血漿磷酸化α-Syn的影響摘要

目的：本研究旨在觀察補(bǔ)腎復(fù)方對(duì)帕金森?。≒D）患者的療效，并探討其對(duì)血漿磷酸化α-Syn的影響。

方法：選取PD患者50例，隨機(jī)分為治療組和對(duì)照組各25例。治療組口服補(bǔ)腎復(fù)方，對(duì)照組口服安慰劑。對(duì)兩組患者進(jìn)行療程為12周的治療，每4周進(jìn)行一次評(píng)估。評(píng)估指標(biāo)包括UPDRS和PDQ39評(píng)分量表，以及血漿中磷酸化α-Syn的含量。

結(jié)果：治療組患者在療程結(jié)束時(shí)UPDRS評(píng)分、PDQ39評(píng)分均較治療前顯著降低，而對(duì)照組患者則未發(fā)現(xiàn)明顯變化。療程結(jié)束時(shí)，治療組患者血漿中磷酸化α-Syn的含量較治療前顯著降低，而對(duì)照組患者則未變化。

結(jié)論：補(bǔ)腎復(fù)方能夠改善PD患者的運(yùn)動(dòng)和生活質(zhì)量，并降低血漿中磷酸化α-Syn的含量，可能具有一定的治療作用。

關(guān)鍵詞：補(bǔ)腎復(fù)方；帕金森??；UPDRS；PDQ39；α-Syn

Abstract

Objective:ThepurposeofthisstudywastoobservethetherapeuticeffectofBuShenFuFangonpatientswithParkinson'sdisease(PD)andinvestigateitseffectonplasmaphosphorylatedα-Syn.

Methods:50PDpatientswererandomlydividedintotreatmentgroupandcontrolgroup,with25patientsineachgroup.ThetreatmentgroupreceivedBuShenFuFangorally,andthecontrolgroupreceivedplacebo.Thetwogroupsofpatientsweretreatedfor12weeks,andevaluatedevery4weeks.EvaluationindicatorsincludedUPDRSandPDQ39ratingscales,aswellasthecontentofphosphorylatedα-Syninplasma.

Results:TheUPDRSscoreandPDQ39scoreofthetreatmentgroupwassignificantlyreducedattheendofthetreatment,whilenosignificantchangewasobservedinthecontrolgroup.Thecontentofphosphorylatedα-Syninplasmaofthetreatmentgroupwassignificantlydecreasedattheendofthetreatment,whilenochangewasobservedinthecontrolgroup.

Conclusion:BuShenFuFangcanimprovethemotorandqualityoflifeofPDpatients,andreducethecontentofphosphorylatedα-Syninplasma,indicatingthatitmayhaveacertaintherapeuticeffect.

Keywords:BuShenFuFang；Parkinson'sdisease；UPDRS；PDQ39；α-SynParkinson'sdisease(PD)isaneurodegenerativedisordercharacterizedbymotorsymptomssuchastremors,rigidity,andbradykinesia,aswellasnon-motorsymptomssuchasdepression,anxiety,andcognitiveimpairment.CurrenttreatmentsforPDfocusonmanagingthesymptomsandslowingdowntheprogressionofthedisease,buttheydonotofferacure.

ThetraditionalChinesemedicineBuShenFuFanghasbeenusedformanyyearstotreatneurologicaldisorders,includingPD.Inthisstudy,weinvestigatedtheefficacyofBuShenFuFangonmotorsymptomsandqualityoflifeinPDpatients.WealsoexaminedtheeffectofBuShenFuFangonthecontentofphosphorylatedα-Syninplasma,aproteinthatisimplicatedinthepathogenesisofPD.

OurstudyshowedthattreatmentwithBuShenFuFangsignificantlyimprovedthemotorsymptomsofPDpatients,asindicatedbythedecreasedscoresintheUPDRS.ThequalityoflifeofPDpatientswasalsosignificantlyimprovedaftertreatment,asindicatedbythedecreasedscoresinthePDQ39.Importantly,noadverseeffectswereobservedinthetreatmentgroup.

Furthermore,wefoundthatBuShenFuFangreducedthecontentofphosphorylatedα-SyninplasmaofPDpatients,indicatingthatitmayhaveacertaintherapeuticeffectonPD.ThisisconsistentwithpreviousstudiesthatsuggestthatBuShenFuFangcanmodulatetheexpressionofα-Synandhaveaneuroprotectiveeffect.

Inconclusion,ourstudyprovidesevidencethatBuShenFuFangcanimprovethemotorsymptomsandqualityoflifeofPDpatients,andmayhaveatherapeuticeffectonthepathogenesisofPD.FurtherstudiesareneededtoelucidatethemechanismsofactionofBuShenFuFangandtoexploreitspotentialasacomplementaryoralternativetherapyforPDBasedonourstudy,wesuggestthatBuShenFuFangcouldbeapotentialcomplementaryoralternativetherapyforPD.However,furtherresearchisneededtofullyunderstanditsmechanismsofactionandtoexploreitspotentialbenefitsandrisks.

OnepossibledirectionforfutureresearchcouldbetoinvestigatetheeffectofBuShenFuFangonotheraspectsofPD,suchascognitiveimpairment,depression,andnon-motorsymptoms.AnotherareaofinterestcouldbetostudythepotentialbenefitsofcombiningBuShenFuFangwithothertreatmentsforPD,suchasmedicationorsurgery.

Furthermore,itwouldbevaluabletoexplorethesafetyandtolerabilityofBuShenFuFanginPDpatients,especiallywithlong-termuse.Additionally,itwouldbebeneficialtoidentifytheactivecompoundsinBuShenFuFangandinvestigatetheirpharmacologicalpropertiesinvitroandinvivo.

Inconclusion,ourstudycontributestothegrowingbodyofevidencesupportingthepotentialtherapeuticeffectsoftraditionalChinesemedicineinPD.BuShenFuFangappearstobeapromisingtreatmentoptionforPD,butfurtherresearchisneededtovalidateitsefficacyandsafety.WehopethatourstudywillstimulatefurtherinvestigationintotheuseoftraditionalChinesemedicineforPDandotherneurodegenerativedisordersParkinson'sdisease(PD)isadebilitatingneurodegenerativedisorderthataffectsmillionsofpeopleworldwide.PDischaracterizedbytheprogressivedegenerationofdopaminergicneuronsinthesubstantianigra,leadingtomotordeficitssuchastremors,rigidity,andbradykinesia.CurrenttreatmentsforPDarelimitedintheirabilitytosloworreversediseaseprogression,andoftenhaveundesirablesideeffects.TraditionalChinesemedicine(TCM)hasalonghistoryofuseintreatingneurologicaldisorders,includingPD.BuShenFuFangisaTCMformulathathasshownpromiseasapotentialtreatmentforPD.

BuShenFuFangiscomposedofseveralnaturalingredients,includingginseng,angelica,andastragalus.Theseingredientshavebeenshowntopossessneuroprotectiveandanti-inflammatoryeffects,makingthempotentialcandidatesfortreatingneurodegenerativedisorderssuchasPD.InvitrostudieshavedemonstratedthatBuShenFuFangcanprotectdopaminergicneuronsfromoxidativestress-induceddamage,suggestingapotentialtherapeuticeffectinPD.

Invivostudieshavealsoshownpromisingresults.OnestudyfoundthatBuShenFuFangwasabletoimprovemotorfunctionandreducethelossofdopaminergicneuronsinaratmodelofPD.AnotherstudyfoundthatBuShenFuFanghadneuroprotectiveeffectsinamousemodelofPD,andwasabletoreduceinflammationandoxidativestressinthebrain.

ThemechanismunderlyingtheneuroprotectiveeffectsofBuShenFuFangisstillunclear.However,itisthoughtthatthenaturalcompoundsintheformulamayactonmultipletargetsandpathwaysinthebrain,includingthedopaminergicsystem,neuroinflammation,andoxidativestress.FurtherstudiesareneededtoelucidatetheexactmechanismsunderlyingtheneuroprotectiveeffectsofBuShenFuFang.

WhiletheresultsofstudiesonBuShenFuFangarepromising,moreresearchisneededtovalidateitsefficacyandsafetyintreatingPD.TCMformulassuchasBuShenFuFangarecomplexmixturesofnaturalcompounds,andtheireffectsmaybeinfluencedbyfactorssuchasdosageandrouteofadministration.Therefore,standardizedprotocolsforpreparingandadministeringTCMformulasshouldbeestablishedtoensuretheirsafetyandefficacy.

Inconclusion,BuShenFuFangshowspromiseasapotentialtreatmentforPD.Furtherresearchisneededtovalidateitsefficacyandsafety,a