鎂基表面不同改性涂層的生物學(xué)行為研究

鎂基表面不同改性涂層的生物學(xué)行為研究摘要：

隨著人類對(duì)生物材料需求的不斷增加，鎂合金因其良好的生物相容性和生物可降解性，成為了一種備受關(guān)注的生物醫(yī)用材料。但是，隨著異常反應(yīng)的不斷發(fā)生，鎂合金的臨床應(yīng)用受到了一定程度的限制。為了克服這些問(wèn)題，近年來(lái)涂層技術(shù)成為一種很重要的改善鎂合金生物相容性的方法。然而，目前針對(duì)鎂基材料涂層還存在很多問(wèn)題需要研究，比如涂層的材料、結(jié)構(gòu)、組成等等。

本文綜述了目前常用的鎂基表面改性涂層，并介紹了這些涂層的生物學(xué)行為研究進(jìn)展。我們認(rèn)為，各種涂層材料的組合和結(jié)構(gòu)對(duì)于生物學(xué)行為的影響是不同的。因此，我們對(duì)比研究了不同改性涂層的生物學(xué)行為，包括材料的生物相容性、生物腐蝕性、細(xì)胞黏附和增殖、異物反應(yīng)等等。此外，我們探究了涂層表面化學(xué)特性對(duì)細(xì)胞黏附和增殖的影響，從而更全面地了解改性涂層的作用機(jī)制。

研究結(jié)果表明，鎂基表面改性涂層可以顯著改善鎂合金的生物學(xué)性能，并且不同的涂層材料和結(jié)構(gòu)對(duì)生物學(xué)行為產(chǎn)生了不同的影響。此外，表面化學(xué)特性也是影響細(xì)胞黏附和增殖的重要因素。綜上，針對(duì)鎂基材料涂層的生物學(xué)行為研究具有重要的價(jià)值，對(duì)于提高鎂合金的應(yīng)用前景具有重要的意義。

關(guān)鍵詞：鎂基涂層；生物學(xué)行為；表面化學(xué)特性；生物相容性；生物可降解性；異物反應(yīng)；細(xì)胞黏附；維持性能。

Abstract:

Withtheincreasingdemandforbiomaterials,magnesiumalloyhasbecomeawidelystudiedandpromisingbiomedicalmaterialduetoitsexcellentbiocompatibilityandbiodegradability.However,clinicalapplicationofmagnesiumalloyislimitedbytheoccurrenceofadversereactions.Inrecentyears,coatingtechnologyhasbecomeanimportantmethodtoimprovethebiocompatibilityofmagnesiumalloy.However,therearestillmanyproblemstobesolvedincoatingmagnesium-basedmaterials,suchascoatingmaterials,structure,andcomposition,etc.

Inthispaper,wereviewthecommonlyusedmagnesium-basedsurfacemodificationcoatingsandtheresearchprogressontheirbiologicalbehavior.Webelievethatthecombinationandstructureofdifferentcoatingmaterialshavedifferenteffectsonbiologicalbehavior.Therefore,wecomparethebiologicalbehaviorofdifferentmodifiedcoatings,includingbiocompatibility,biodegradability,celladhesionandproliferation,andforeignbodyreaction.Inaddition,weexploredtheeffectsofsurfacechemicalpropertiesoncelladhesionandproliferationtogainamorecomprehensiveunderstandingofthemechanismofactionofmodifiedcoatings.

Theresultsshowthatmagnesium-basedsurfacemodificationcoatingscansignificantlyimprovethebiologicalpropertiesofmagnesiumalloy,anddifferentcoatingmaterialsandstructureshavedifferenteffectsonbiologicalbehavior.Inaddition,surfacechemicalpropertiesarealsoanimportantfactoraffectingcelladhesionandproliferation.Therefore,furtherresearchonthebiologicalbehaviorofmagnesium-basedcoatingsisofgreatvalueandsignificanceforimprovingtheapplicationprospectofmagnesiumalloy.

Keywords:magnesium-basedcoatings;biologicalbehavior;surfacechemicalproperties;biocompatibility;biodegradability;foreignbodyreaction;celladhesion;maintenanceofpropertiesMagnesium-basedcoatingshavereceivedsignificantattentionduetotheirpotentialapplicationinvariousbiodegradablemedicaldevices.However,thebiologicalbehaviorofthesecoatingsiscriticalindeterminingtheirefficacyandpracticalityinsuchapplications.Biocompatibilityandbiodegradabilityaretwoessentialfactorsthatdeterminethebiologicalbehaviorofmagnesium-basedcoatings.

Oneofthecriticalfactorsinthebiocompatibilityofmagnesium-basedcoatingsistheirabilitytoavoidanundesiredforeignbodyreactionbythehosttissue.Thisreactionisoftencharacterizedbyinflammationandencapsulationoftheimplant,leadingtopoorintegrationandfunctioninthehost.Therefore,studiesneedtofocusondevelopingcoatingsthatcanavoidorminimizeforeignbodyreactions.

Celladhesionandproliferationareotherimportantaspectsofthebiologicalbehaviorofmagnesium-basedcoatings.Thesurfacechemicalpropertiesofthecoatingsplayacriticalroleindeterminingtheadhesionandproliferationofcells.Therefore,researchersmusttakeintoaccountthesurfacepropertieswhiledevelopingthecoatings.

Thebiodegradabilityofmagnesium-basedcoatingsisalsoanessentialaspectthataffectstheirbiologicalbehavior.Therateofdegradationofcoatingsshouldmatchtherateoftissuehealingtoavoidanyadverseeffectsonthehealingprocess.Moreover,thebyproductsofthedegradationprocessmustbebiocompatiblewiththehosttissue.

Inconclusion,furtherresearchonthebiologicalbehaviorofmagnesium-basedcoatingsiscrucialinenhancingtheirapplicationprospectinvariousbiodegradablemedicaldevices.Biocompatibility,biodegradability,foreignbodyreactions,celladhesion,andmaintenanceofpropertiesarekeyfactorsthatmustbetakenintoaccounttooptimizetheireffectivenessintheseapplicationsMagnesium-basedcoatingshavegainedattentionaspotentialbiodegradablematerialsinmedicalapplicationsduetotheiruniqueproperties.However,therearestillsomechallengesthatneedtobeaddressedbeforetheirwidespreaduseinclinicalsettingscanbeachieved.

Oneofthemajorchallengesisimprovingtheircorrosionresistance.Therapiddegradationofmagnesium-basedcoatingscanleadtoprematurefailureofmedicalimplants,causingadverseeffectsonthehosttissue.Topreventthis,severalapproacheshavebeenproposed,includingtheadditionofalloyingelementsandsurfacemodificationusingplasmaspraying,electrochemicaldeposition,orsol-gelprocessing.

Anotherchallengeistheforeignbodyreactionthatcanoccurwhenmagnesium-basedcoatingsareimplantedinvivo.Thisreactioninvolvestheactivationofthehostimmunesystem,whichcanresultininflammationandtissuedamage.Toaddressthisissue,researchershavebeenexploringdifferentsurfacemodifications,suchastheuseofcoatingsthatmimictheextracellularmatrixtopromotecelladhesionandreduceinflammation.

Inaddition,themechanicalpropertiesofmagnesium-basedcoatingsneedtobeoptimizedtoensuretheirlong-termperformance.Forexample,thecoatingsshouldmaintaintheirstrengthandelasticityovertimetowithstandthestressesandstrainsofthehosttissueenvironment.

Finally,thedegradationbyproductsofmagnesium-basedcoatingsmustbebiocompatibletoensurethattheydonotcauseanyadverseeffects.Researchershavebeeninvestigatingdifferentstrategiesfortuningthedegradationrateofthesecoatings,suchastailoringthecoatingthicknessorthecompositionofthealloy.

Overall,magnesium-basedcoatingshaveimmensepotentialinthefieldofbiodegradablemedicaldevicesduetotheirbiocompatibilityandbiodegradability.ContinuedresearchanddevelopmentofthesecoatingsisessentialtoovercometheexistingchallengesandtoexpandtheirapplicationprospectsinawiderangeofbiomedicalapplicationsOneareawheremagnesium-basedcoatingsshowgreatpromiseisinorthopedicimplants.Orthopedicimplantsareusedtoreplaceorrepairdamagedordiseasedboneandjointtissue.Traditionally,orthopedicimplantshavebeenmadeofmaterialssuchastitanium,stainlesssteel,andcobalt-chromiumalloys.Whilethesematerialsarestronganddurable,theyarenotbiodegradableandcancauselong-termproblemsinsomepatients.Forexample,metalimplantscaninterferewithmagneticresonanceimaging(MRI)andcancauseallergicreactionsortoxicityovertime.

Magnesium-basedcoatingsofferanumberofadvantagesovertraditionalorthopedicimplantmaterials.First,theyarebiodegradable,whichmeansthattheynaturallydegradeovertime,eliminatingtheneedforadditionalsurgeriestoremovetheimplant.Thisisparticularlyimportantforpediatricpatientswhomayrequiremultiplesurgeriesastheygrow.Additionally,magnesium-basedcoatingsarelightweightandbiocompatible,whichmeansthattheyarelesslikelytocauseinflammationorrejectionbythepatient'simmunesystem.

Anotheradvantageofmagnesium-basedcoatingsisthattheyarehighlycustomizable.Magnesiumalloyscanbetailoredtohavespecificmechanicalandcorrosionproperties,whichmeansthattheycanbedesignedtomatchthestrengthanddurabilityrequirementsofdifferentapplications.Additionally,thethicknessandcompositionofthecoatingscanbeadjustedtocontroltherateofdegradation,allowingthemtobecustomizedfordifferentpatientneeds.

Despitetheseadvantages,therearestillseveralchallengesthatmustbeovercomebeforemagnesium-basedcoatingscanbewidelyusedinorthopedicimplants.Onechallengeisthatmagnesiumalloystendtocorrodequicklyinthepresenceofbodyfluids,whichcancompromisetheirstructuralintegrityandreleasepotentiallytoxicbyproducts.Researchersareworkingonwaystoimprovethecorrosionresistanceofmagnesiumalloysbyadjustingtheircompositionordevelopingnewcoatingtechnologies.

Anotherchallengeisthatthedegradationproductsofmagnesiumalloyscancauseinflammationorotheradverseeffectsinsomepatients.Thisisthoughttoberelatedtotheproductsofmagnesiumionhydrolysis,whicharegeneratedasthecoatingdegrades.Researchers