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鎂基表面不同改性涂層的生物學(xué)行為研究摘要:
隨著人類對(duì)生物材料需求的不斷增加,鎂合金因其良好的生物相容性和生物可降解性,成為了一種備受關(guān)注的生物醫(yī)用材料。但是,隨著異常反應(yīng)的不斷發(fā)生,鎂合金的臨床應(yīng)用受到了一定程度的限制。為了克服這些問(wèn)題,近年來(lái)涂層技術(shù)成為一種很重要的改善鎂合金生物相容性的方法。然而,目前針對(duì)鎂基材料涂層還存在很多問(wèn)題需要研究,比如涂層的材料、結(jié)構(gòu)、組成等等。
本文綜述了目前常用的鎂基表面改性涂層,并介紹了這些涂層的生物學(xué)行為研究進(jìn)展。我們認(rèn)為,各種涂層材料的組合和結(jié)構(gòu)對(duì)于生物學(xué)行為的影響是不同的。因此,我們對(duì)比研究了不同改性涂層的生物學(xué)行為,包括材料的生物相容性、生物腐蝕性、細(xì)胞黏附和增殖、異物反應(yīng)等等。此外,我們探究了涂層表面化學(xué)特性對(duì)細(xì)胞黏附和增殖的影響,從而更全面地了解改性涂層的作用機(jī)制。
研究結(jié)果表明,鎂基表面改性涂層可以顯著改善鎂合金的生物學(xué)性能,并且不同的涂層材料和結(jié)構(gòu)對(duì)生物學(xué)行為產(chǎn)生了不同的影響。此外,表面化學(xué)特性也是影響細(xì)胞黏附和增殖的重要因素。綜上,針對(duì)鎂基材料涂層的生物學(xué)行為研究具有重要的價(jià)值,對(duì)于提高鎂合金的應(yīng)用前景具有重要的意義。
關(guān)鍵詞:鎂基涂層;生物學(xué)行為;表面化學(xué)特性;生物相容性;生物可降解性;異物反應(yīng);細(xì)胞黏附;維持性能。
Abstract:
Withtheincreasingdemandforbiomaterials,magnesiumalloyhasbecomeawidelystudiedandpromisingbiomedicalmaterialduetoitsexcellentbiocompatibilityandbiodegradability.However,clinicalapplicationofmagnesiumalloyislimitedbytheoccurrenceofadversereactions.Inrecentyears,coatingtechnologyhasbecomeanimportantmethodtoimprovethebiocompatibilityofmagnesiumalloy.However,therearestillmanyproblemstobesolvedincoatingmagnesium-basedmaterials,suchascoatingmaterials,structure,andcomposition,etc.
Inthispaper,wereviewthecommonlyusedmagnesium-basedsurfacemodificationcoatingsandtheresearchprogressontheirbiologicalbehavior.Webelievethatthecombinationandstructureofdifferentcoatingmaterialshavedifferenteffectsonbiologicalbehavior.Therefore,wecomparethebiologicalbehaviorofdifferentmodifiedcoatings,includingbiocompatibility,biodegradability,celladhesionandproliferation,andforeignbodyreaction.Inaddition,weexploredtheeffectsofsurfacechemicalpropertiesoncelladhesionandproliferationtogainamorecomprehensiveunderstandingofthemechanismofactionofmodifiedcoatings.
Theresultsshowthatmagnesium-basedsurfacemodificationcoatingscansignificantlyimprovethebiologicalpropertiesofmagnesiumalloy,anddifferentcoatingmaterialsandstructureshavedifferenteffectsonbiologicalbehavior.Inaddition,surfacechemicalpropertiesarealsoanimportantfactoraffectingcelladhesionandproliferation.Therefore,furtherresearchonthebiologicalbehaviorofmagnesium-basedcoatingsisofgreatvalueandsignificanceforimprovingtheapplicationprospectofmagnesiumalloy.
Keywords:magnesium-basedcoatings;biologicalbehavior;surfacechemicalproperties;biocompatibility;biodegradability;foreignbodyreaction;celladhesion;maintenanceofpropertiesMagnesium-basedcoatingshavereceivedsignificantattentionduetotheirpotentialapplicationinvariousbiodegradablemedicaldevices.However,thebiologicalbehaviorofthesecoatingsiscriticalindeterminingtheirefficacyandpracticalityinsuchapplications.Biocompatibilityandbiodegradabilityaretwoessentialfactorsthatdeterminethebiologicalbehaviorofmagnesium-basedcoatings.
Oneofthecriticalfactorsinthebiocompatibilityofmagnesium-basedcoatingsistheirabilitytoavoidanundesiredforeignbodyreactionbythehosttissue.Thisreactionisoftencharacterizedbyinflammationandencapsulationoftheimplant,leadingtopoorintegrationandfunctioninthehost.Therefore,studiesneedtofocusondevelopingcoatingsthatcanavoidorminimizeforeignbodyreactions.
Celladhesionandproliferationareotherimportantaspectsofthebiologicalbehaviorofmagnesium-basedcoatings.Thesurfacechemicalpropertiesofthecoatingsplayacriticalroleindeterminingtheadhesionandproliferationofcells.Therefore,researchersmusttakeintoaccountthesurfacepropertieswhiledevelopingthecoatings.
Thebiodegradabilityofmagnesium-basedcoatingsisalsoanessentialaspectthataffectstheirbiologicalbehavior.Therateofdegradationofcoatingsshouldmatchtherateoftissuehealingtoavoidanyadverseeffectsonthehealingprocess.Moreover,thebyproductsofthedegradationprocessmustbebiocompatiblewiththehosttissue.
Inconclusion,furtherresearchonthebiologicalbehaviorofmagnesium-basedcoatingsiscrucialinenhancingtheirapplicationprospectinvariousbiodegradablemedicaldevices.Biocompatibility,biodegradability,foreignbodyreactions,celladhesion,andmaintenanceofpropertiesarekeyfactorsthatmustbetakenintoaccounttooptimizetheireffectivenessintheseapplicationsMagnesium-basedcoatingshavegainedattentionaspotentialbiodegradablematerialsinmedicalapplicationsduetotheiruniqueproperties.However,therearestillsomechallengesthatneedtobeaddressedbeforetheirwidespreaduseinclinicalsettingscanbeachieved.
Oneofthemajorchallengesisimprovingtheircorrosionresistance.Therapiddegradationofmagnesium-basedcoatingscanleadtoprematurefailureofmedicalimplants,causingadverseeffectsonthehosttissue.Topreventthis,severalapproacheshavebeenproposed,includingtheadditionofalloyingelementsandsurfacemodificationusingplasmaspraying,electrochemicaldeposition,orsol-gelprocessing.
Anotherchallengeistheforeignbodyreactionthatcanoccurwhenmagnesium-basedcoatingsareimplantedinvivo.Thisreactioninvolvestheactivationofthehostimmunesystem,whichcanresultininflammationandtissuedamage.Toaddressthisissue,researchershavebeenexploringdifferentsurfacemodifications,suchastheuseofcoatingsthatmimictheextracellularmatrixtopromotecelladhesionandreduceinflammation.
Inaddition,themechanicalpropertiesofmagnesium-basedcoatingsneedtobeoptimizedtoensuretheirlong-termperformance.Forexample,thecoatingsshouldmaintaintheirstrengthandelasticityovertimetowithstandthestressesandstrainsofthehosttissueenvironment.
Finally,thedegradationbyproductsofmagnesium-basedcoatingsmustbebiocompatibletoensurethattheydonotcauseanyadverseeffects.Researchershavebeeninvestigatingdifferentstrategiesfortuningthedegradationrateofthesecoatings,suchastailoringthecoatingthicknessorthecompositionofthealloy.
Overall,magnesium-basedcoatingshaveimmensepotentialinthefieldofbiodegradablemedicaldevicesduetotheirbiocompatibilityandbiodegradability.ContinuedresearchanddevelopmentofthesecoatingsisessentialtoovercometheexistingchallengesandtoexpandtheirapplicationprospectsinawiderangeofbiomedicalapplicationsOneareawheremagnesium-basedcoatingsshowgreatpromiseisinorthopedicimplants.Orthopedicimplantsareusedtoreplaceorrepairdamagedordiseasedboneandjointtissue.Traditionally,orthopedicimplantshavebeenmadeofmaterialssuchastitanium,stainlesssteel,andcobalt-chromiumalloys.Whilethesematerialsarestronganddurable,theyarenotbiodegradableandcancauselong-termproblemsinsomepatients.Forexample,metalimplantscaninterferewithmagneticresonanceimaging(MRI)andcancauseallergicreactionsortoxicityovertime.
Magnesium-basedcoatingsofferanumberofadvantagesovertraditionalorthopedicimplantmaterials.First,theyarebiodegradable,whichmeansthattheynaturallydegradeovertime,eliminatingtheneedforadditionalsurgeriestoremovetheimplant.Thisisparticularlyimportantforpediatricpatientswhomayrequiremultiplesurgeriesastheygrow.Additionally,magnesium-basedcoatingsarelightweightandbiocompatible,whichmeansthattheyarelesslikelytocauseinflammationorrejectionbythepatient'simmunesystem.
Anotheradvantageofmagnesium-basedcoatingsisthattheyarehighlycustomizable.Magnesiumalloyscanbetailoredtohavespecificmechanicalandcorrosionproperties,whichmeansthattheycanbedesignedtomatchthestrengthanddurabilityrequirementsofdifferentapplications.Additionally,thethicknessandcompositionofthecoatingscanbeadjustedtocontroltherateofdegradation,allowingthemtobecustomizedfordifferentpatientneeds.
Despitetheseadvantages,therearestillseveralchallengesthatmustbeovercomebeforemagnesium-basedcoatingscanbewidelyusedinorthopedicimplants.Onechallengeisthatmagnesiumalloystendtocorrodequicklyinthepresenceofbodyfluids,whichcancompromisetheirstructuralintegrityandreleasepotentiallytoxicbyproducts.Researchersareworkingonwaystoimprovethecorrosionresistanceofmagnesiumalloysbyadjustingtheircompositionordevelopingnewcoatingtechnologies.
Anotherchallengeisthatthedegradationproductsofmagnesiumalloyscancauseinflammationorotheradverseeffectsinsomepatients.Thisisthoughttoberelatedtotheproductsofmagnesiumionhydrolysis,whicharegeneratedasthecoatingdegrades.Researchers
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