Olanexidine-DataSheet-生命科學試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEOlanexidineCat.No.:HY-125654CASNo.:146510-36-3分?式:C??H??Cl?N?分?量:372.34作?靶點:Bacterial作?通路:Anti-infection儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性O(shè)lanexidine?種抗劑。Olanexidine對多種細都有抗活性，包括?蘭?陽性和?蘭?性細。Olanexidine也?種防腐劑。Olanexidine可?于感染和炎癥的研究。體外研究Olanexidine(50μM,48h)exhibitsbroad-spectrumbactericidalactivityagainstGram-positivecocciandGram-negativebacteria[1].Olanexidine(50μg/mL,24h)inhibitschronicinflammatoryreactionsinoralmucosalcells[2].Olanexidine(Olanexidinegluconate,0-15000μg/mL)inhibitsthebindingabilityofvirus-likeparticlestothebindingreceptorofhumannorovirusandincreasestheaggregationofvirus-likeparticles[3].CellViabilityAssay[1]CellLine:Gram-positivecocci,Enterococcusspp.,Gram-positivebacilli,Gram-negativestrainsConcentration:0-1mg/mLapproximatelyIncubationTime:30sResult:InhibitedbacterialactivitywithMICvaluesrangingfrom6.8to1740μg/mLapproximately.體內(nèi)研究Olanexidine(1-2%insaline,appliedtotheskin)isactiveagainsttransientorresidentbacterialfloraontheskinofmalecynomolgusmonkeys[4].AnimalModel:Malecynomolgusmonkeys[4]1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEDosage:1%,1.5%,2%insalineAdministration:AppliedtotheskinResult:Showedthefast-actingandlong-lastingbactericidaleffectsat1.5%concentration.REFERENCES[1].HagiA,etal.BactericidalEffectsandMechanismofActionofOlanexidineGluconate,aNewAntiseptic.AntimicrobAgentsChemother.2015Aug;59(8):4551-9.[2].NiiT,YumotoH,HirotaK,MiyakeY.Anti-inflammatoryeffectsofolanexidinegluconateonoralepithelialcells.BMCOralHealth.2019Nov8;19(1):239.[3].ImaiK,etal.Disinfectionefficacyandmechanismofolanexidinegluconateagainstnorovirus.AmJInfectControl.2022Jul;50(7):764-771.[4].NakataH,etal.Effectsofolanexidinegluconateonpreoperativeskinpreparation:anexperimentalstudyincynomolgusmonkeys.JMedMicrobiol.2017May;66(5):678-685.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseon