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RickettsialDiseasesGeneralintroductionGram-negative,obligateintracellularcoccobacilli

bacteriathatinfectmammaolsandarthropodsRickettsiaearetransmittedinthearthropods,whichservesasbothvectorandreserviorBothDNAandRNAIssensitivetoantibiotic.CategoryofrickettsiaGenusRickettsia,Coxiella,Orientia,EhrlichiaBartonellaSpeciesRickettsiaprowazekii(epidemictyphus),Rickettsiatyphi(endemictyphus),Rickettsiarickettsii(spottedfever),Rochalimaeaquintana(trenchfever),Coxiellaburnetii(Qfever)BilogicalfeaturesVariableshape,coccobacilliGramnegativeMicrocapsuleandslimlayerCulture:inyorksacsofembryonatedeggsReplicationcycleofRickettsiaand

Orientia

AntigenicstructureLPS

RickettsiatsutsugamushiCoxiellaburnetii(Qfever)LPSⅠsmoothLPSⅡroughWeil-FelixreacrionSurfaceprotein(SPA)TransmissionTyphus,spottedfeverandtrenchfeveraretransmittedviaarthropodvectors;Qfeverisacquiredviainhalationoringestionofcontaminatedmilkorfood.PathogenesisVirulencefactors:endotoxin,phospholipaseA,andslimelayerSites:vascularsystemproducingvasculitis血管炎Characteristictriadofsymptoms:fever,headacheandrash(norashwithQfever).Rickettsiaprowazekii

普氏立克次體epidemictyphusaverageincubationperiods(days):8thelouseRespiratorytractandconjunctivaLatentperiod:2weeksAbruptonset,fever,chills,headache,myalgia,arthralgiaRickettsiatyphi

地方性斑疹傷寒立克次體endemictyphus7-14daysMicethelouse&fleaMouth,noseandconjunctivaGradualonset,fever,headache,myalgia,coughRickettsiatsutsugamushi

恙蟲病立克次體Tsutsugamushidisease(scrubtyphus)MicetsutsugamushiBlackeachar焦痂Coxiellaburnetti貝納柯斯體QfeverCowandsheeptickHighresistanceabruptonset,fever,headache,chills,myalgia,granulomatoushepatitischronicdiaeasewithsubacuteonset,endocarditis,hepaticdysfunctionReplicationofC.burnetiiGeneralizedLifeCycleof

DermacentorvariabilisandDermacentorandersoniTicks

Bartonellahenselae漢賽巴通體CSD(catscratchdisease)CatanddogConjunctivainflammationandlymphnodeswellEhrlichia埃里希體屬Ehrlichiachaffeensis:humanmonocytotropicehrlichiosisEhrlichiasennetsu:humangranulocytotropicehrlichiosisReplicationofEhrlichia埃里希體ProposedlifecyclefortheagentofHumanGranulocyticEhrlichiosis埃里希體病DiagnosisTheuseofimmunofluorescentantibodiestoexamineabiopsycanbediagnostic.Theorganismcanbeinoculatedintotissuecultureandgrownover4-7daysbutthisisveryhazardoustopersonnel.TheWeil-FelixtestlooksfortheproductionofserumantibodythatisreactiveagainstProteusOX19,OX2orOXKantigensbutitisnotalwaysreliable.ControlSanitary:Arthro

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