版權說明:本文檔由用戶提供并上傳,收益歸屬內容提供方,若內容存在侵權,請進行舉報或認領
文檔簡介
2022年安徽省巢湖市大學英語6級大學英語六級真題一卷(含答案)學校:________班級:________姓名:________考號:________
一、2.ReadingComprehension(SkimmingandScanning)(20題)1.
TokeeptheEarthoutofwarm,wecandestroytheMethanewith______.
A.greenhousegasB.sunlightC.waterD.oxygen
2.
Insuranceagainstrisksatanacceptablepricecanonlyberealizedwhentheamountofpeoplefacingthesimilarriskisquitelarge.
A.YB.NC.NG
3.
Laptopsequippedwith___________________canallowtheirownerstotemporarilydealwithofficeworkinsomepublicplaces.
4.
ThearticledemonstrateswhatwillhappenintheInformationMarketplacethroughthediscoveries.
A.YB.NC.NG
5.Amongdevelopedcountries,______spendsthegreatestshareofGDPonthepublicbroadcasting.
A.USgovernment
B.Britishgovernment
C.Germangovernment
D.Frenchgovernment
6.
Theschoolsadvocatingconstructivistmatharguethetraditionalparentsareaccustomedtobeingdeeplyinvolved______theirchildren'slives.
7.
A"SloppyJoe"combinescheeseandhamburgermeattogether.
A.YB.NC.NG
8.
MarkTwaingotmarriedwhenhewas______yearsold.
9.WhatisthemainfindingofDonaldL.McCabe'ssurveys?
A.Moreundergraduatesadmittedtocopyingafewsentencesinwrittenassignments.
B.Lessundergraduatesadmittedtocopyingafewsentencesinwrittenassignments.
C.MoreundergraduatestakeplagiarismfromtheWebforgrantednowadays.
D.LessundergraduatesarecopyingfromtheWebthanearlierinthedecade.
10.
Theauthormaintainsasthemarketsdistributeothergoodsthroughouttheeconomyandcostsomethingtheycanbeseenas______.
11.PartⅡReadingComprehension(SkimmingandScanning)
Directions:Inthispart,youwillhave15minutestogooverthepassagequicklyandanswerthequestionsonAnswerSheet1.Forquestions1-7,choosethebestanswerfromthefourchoicesmarkedA,B,CandD.Forquestions8-10,completethesentenceswiththeinformationgiveninthepassage.
TheDarkestSideofIDTheft
March9,2003—MalcolmByrdwashomeonaSaturdaynightwhenaknockcame.ThreeRockCountry,Wis.,sheriff'sofficersweretherewithawarrantforByrd'sarrest.Cocainepossession,withintenttodistribute,itsaid.Byrdtriedtotellthemthattheyhadthewrongman,thatitwasacaseofmistakenidentity.Buttheywouldn'tlisten.Insteadtheyputhiminhandcuffs(手銬)anddrovehimaway.
ItwasnothingnewforByrd,whohasspentmuchofthepastfiveyearstrying—unsuccessfully—totalkskepticalpoliceofficersoutofarrestinghim.Butthistime,itwasworse.Twodayslater,hewasstillinjail.
Thisistheworstthingforidentitytheftvictims.Losingyourcleancredithistoryisonething;losingyoufreedomisanother.AndvictimsofAmerica'sfastest-growingcrimearediscoveringtheyoftenhavemuchmoretoworryaboutthanthehundredsofhoursofpaperworktocleanupthefinancialmessassociatedwithIDtheft.Sometimes,theyhavetoworryaboutbeingpushedinjail—againandagain.
Alias(化名)BecomesaDisease
There'snothingnewaboutcriminalsusingaliasestoevadethelaw.Criminalsoftentrytogivetheirfriend'sname,address,anddateofbirthtocheatpolice.Buttheexplosionofidentitytheft,andthereadyavailabilityofstolendigitalfilesoninnoeentvictims,makesitjustaseasyforacriminaltogiveastranger'spersonaldataduringanarrest.Oncepolicebookasuspectunderafakename,thatmistakecanplagueavictimforlife.TheAliasbecomesadiseasetothetrueownerofthatcharacter.
Gettingnamesoffthoselistscanbeabigtask.Theproblemiscomplicatedbytheincreasingsophisticationoflawenforcementofficials."Officialsofcriminalrecordsare—forgoodreason—reluctanttoremoveinformationonceit'sbeenplacedinthedatabase,"saidBethGivens,executivedirectoroftheIdentityTheftClearingHouse.
HisWordAgainstaDatabase
InByrd'scase,hiswordhasneverbeenenough.ThesituationhaslefttheJanesville,Wis.,manthinkingaboutnamechanging.Withhisimpostor(冒名頂替者)stillcommittingcrimesandstillusinghisname,Byrdfearsanotherarrest."Idon'tfeelsafenow.WhenwedriveIfeeluncomfortable,"Byrdsaid."It'saffectedourlivesenormously."
TomSchroeder,afamouslawyer,confirmedmanyofthedetailofByrd'srepeatedrun-inswiththelaw."Mr.ByrdisworriedthatifheisinMilwaukeeCountyandgetsstoppedforsomereasonandtheofficerputsitintoacomputer,hemaystillcomeup,'Schroedersaid."AndIdon'tblamehim."
EffortstoeliminateByrd'scriminalrecordatthestateandfederallevelhaven'tsucceeded,Schroedersaid."IleftavoicemailonMr.Byrd'sphoneindicatingwe'dbehappytohelphimchangehisnameandhisSocialSecuritynumber."
HowItBegan
Byrd'snightmarebeganin1998,hesaid.AmanarrestedondrugchargesthatyearidentifiedhimselftolocaiofficialsasMalcolmByrd.
ThankstoanarticleinthelocalJanesvilleGazette,therealMalcolmByrdfoundoutabouttheidentitytheft,andheadedtothepolicetocorrecttheerror.Thepaperranacorrection,too.Butthatwashardlytheendofthenightmare.
Fourmonthslater,whenhewasstoppedforspeeding,Byrdfoundhimselffacedownonthepavement,handcuffed.Policerecordsstillshowedthathewaswantedfordrugdealing.
Thematterwascl
A.hewasavictimofidentitytheft
B.thepoliceofficersarrestedthewrongman
C.hewasfoundtopossesssomecocaine
D.hewaswantedbythepolice
12.
Manycitiesoffer______.that.cansaveyoumoneyandensureyoursafety.
13.
Thebookhasmorethanoneauthor.
A.YB.NC.NG
14.
Alternativesentencingisnowpracticedin______siatesandisspreadingfast.
15.
Theauthorsteppedoutoftheliftat______.
16.Whenreservingahotelroomwithyourcheckcard,youhavetodecidehowmuchmoneyinyouraccounthastobeonhold.
17.
Foranexam,thecrammeralwayschoosetowaituntil______.
18.Divorce
Forevery1,000marriedcouplesintheUK,13endupdivorcedaccordingtostatistics.Divorceisoftenacomplicatedandmessyprocess,andthrowsupmanypitfalls.
Divorceissues
Suchthornyissuesaswhethertosellyourhome,whichparentwilllookafteryourchildren,andhowitwillaffectanyloansyou-mayhave,willallhavetoberesolved.AndifyouaredivorcingyourpartnerinScotlandratherthaninEnglandandWalesthenanothersetoflawswillapply.
Formanycouples,obtainingadivorcehasneverbeeneasier.Theold-fashionedconceptofestablishingthat"onepartyisatfault"hasbeenconsignedtohistoryandtheimportantfacttoestablishnowisthattherelationshiphas"irretrievablybrokendown".
Incourtoronline?
Itisevenpossibletodivorceyourpartneronline,allowingyoutosaveonlegalcosts—andaccordingtoonlineexperts,thiscansaveyouabout£700fromtheaverage£800.However,thismethodisonlysuitableforverystraightforwardanduncontesteddivorces.
Alternatively,youcanapplyfordivorceatacountycourtinEnglandandWales,buttodothis,couplesmusthavebeenmarriedforatleastayear.
Thefirststageofdivorceisobtainingwhatisknownasa"Decreenisi(日后才生效的離婚判決書)".Thisisgrantedifthecourtissatisfiedthemarriagehas"irretrievablybrokendown",andthisisprovenbyshowingoneoffivethings:adultery(通奸行為);unreasonablebehaviour;desertiononthepartofonepartnerforatleasttwoyears;thatthecouplehavebeenseparatedfortwoyearsandbothspousesconsenttodivorce;orthatthecouplehavebeenseparatedforfiveyearn.
Yourspouse's"unreasonablebehaviour"mustbesointolerablethatnobodycouldreasonablyexpectyoutocarryonlivingwithhimorher.Itcouldinclude,forexample,financialrecklessness,drinking,gambling,orlackofemotionalsupport.Youcannotbaseyourdivorceonthisifyouthenlivetogetherforaperiodofmorethansixmonthsafterwards.Thisrulealsoappliestodesertion,andthediscoverythatadulteryhastakenplace.
Thesecondandfinalstageisobtaininga"Decreeabsolute"(絕對判決).Thedivorcecanbestoppedatanytimeuntilthisisgranted,soitisadvisabletosortoutallthefinancialandpracticaldetailsfirst.
Usingadivorcelawyer
If,asinthevastmajorityofcases,yourrelationshipiscomplicated,itisadvisabletoseeklegaladvicefromareputablefamilylawsolicitor,whowillbeabletoproperlyadviseyouaboutyourfightsandresponsibilities.
IfyouareunsurehowtogoaboutchoosingasolicitorthenitmightbeagoodideatoconsulttheLawSocietyortheFamilyLawSolicitorsAssociation,whokeepalistofaccreditedlawyers.AlternativelyvisittheCitizen'sAdviceBureauwhohasagreatdealofinformationregardingsuchmatters.
Whatarethealternatives?
Mediationisavoluntaryservicethatallowsyouandyourpartnertomeetwithatrainedandimpartialnegotiator(themediator)toclarifytheissues,discusstheavailableoptions,andreachdecisionsacceptabletoyouboth.Whilethemediatorwillmanagetheprocessofnegotiation,heorsheisnottheretopromoteeitherperson'sinterests.Thedecisionsareultimatelyyours.
Youwillstillrequiretheservicesofasolicitortoputyourdecisionsonpropertyorfinancialmattersintolegalform.Thegovernmentiskeenforpeopletoattendmediation,andthenumberofpeopleofferingthisservicehasvastlyincreasedinthelastfewyears.Youmayberequiredtoattendmediationsessionsifyourdivorceisfundedbylegalaid.FormoreinformationvisitourfeatureonMediation.
Whataboutthechildren?
Divorcecanbeespeciallyconfusingforchildren,whoarelikelytofeelbewilderedbyeventsandm
A.YB.NC.NG
19.
Inordertopreventyourbooksfrombeingdamagedbyinsects,youshouldmakeyourlibraryavoid______.
20.Ifyoufailtosay"thankyou"tothereceptionists,theywillhavenegativeimpressionsofyou.
二、3.ListeningComprehension(20題)21.聽力原文:M:IneedabookforEnglishtwo-twenty-oneandanotebook.
W:Allofthetextbooksareontheshelvesinthebackofthestore.Thenotebooksareovertherebythecashregister.
Q:Wheredidthisconversationmostprobablytakeplace?
(15)
A.Inabookstore.
B.Inalibrary.
C.Inaclassroom.
D.Inahotel.
22.(28)
A.Theylivedaluxuriouslifeandtheirdietwasverydelicate.
B.Theylivedahighlycivilizedcourtlife.
C.Theylivedaprimitivelifeandtheirtablemannerswereoftenrude.
D.Theylivedacomparativelyluxuriousbutnot-so-civilizedlife.
23.(18)
A.She'lldefinitelygetagoodgradebecauseshedidn'tuseInternetsources.
B.She'llprobablydobadlyonherpapersincesheusednothingbutInternetsources.
C.She'llgetabadgradebecausesheusedInternetsourcesratherthananythingelse.
D.Shewondershowwellshe'llperform.onherpaperforusingInternetsources.
24.【B9】
25.【B2】
26.SectionB
Directions:Inthissection,youwillhear3shortpassages.Attheendofeachpassage,youwillhearsomequestions.Boththepassageandthequestionswillbespokenonlyonce.Afteryouhearaquestion,youmustchoosethebestanswerfromthefourchoicesmarkedA,B,CandD.
聽力原文:Therearemanywaystoloseweight.Firstofall,startsmall.Smallchangesarealoteasiertostickwiththandrasticones.Tryreducingthesizeoftheportionsyoueatandgivingupregularsodaforaweek.Onceyouhavethatdown,startgraduallyintroducinghealthierfoodsandexerciseintoyourlife.
Second,stopeatingwhenyou'refull.Lotsofpeopleeatwhenthey'rebored,lonely,orstressed,orkeepeatinglongafterthey'refulloutofhabit.Trytopayattentionasyoueatandstopwhenyou'refull.Slowingdowncanhelpbecauseittakesabout20minutesforyourbraintorecognizehowmuchisinyourstomach.Sometimestakingabreakbeforegoingforsecondscankeepyoufromeatinganotherserving.
Avoideatingwhenyoufeelupsetorbored,trytofindsomethingelsetodoinstead(awalkaroundtheblockoratriptothegymaregoodalternatives).Manypeoplefindit'shelpfultokeepadiaryofwhattheyeatandwhen.Reviewingthediarylatercanhelpthemidentifytheemotionstheyhavewhentheyovereatorwhethertheyhaveunhealthyhabits.Aregistereddietitiancangiveyoupointersonhowtodothis.
Third,eatlessmoreoften.Manypeoplefindthateatingacoupleofsmallsnacksthroughoutthedayhelpsthemtomakehealthychoicesatmeals.Stickacoupleofhealthysnacksinyourbackpacksothatyoucanhaveoneortwosnacksduringtheday.Addinghealthysnackstoyourthreesquaresandeatingsmallerportionswhenyousitdowntodinnercanhelpyoucutcalorieswithoutfeelingdeprived.
(27)
A.Becauseittakestimebeforeyourbrainrealizesthatyou'refull.
B.Becausethesloweryoueat,thelessyouabsorb.
C.Becauseit'shealthiertoeatslowly.
D.Becauseithelpstohumthefatinyourbody.
27.(32)
A.Differencesbetweenpeopleswillgraduallydisappear.
B.Thetourismindustrywillbecomeflourishing.
C.Theworldwillbecomemoreandmoreinteresting.
D.Peopleindifferentcountrieswillstillkeeptheirowncustoms.
28.(34)
A.Bymercilesslyexploitingwomenworkersintheclothingindustry.
B.Bythegreateffortofthefashiondesigners.
C.Bypayingattentiontothequalityinwomen'sclothing.
D.Byconstantlychangingthefashionsinwomen'sclothing.
29.聽力原文:M:Thewashingmachineinourapartmentismorethanseventeenyearsold,anditworkedjustfineuntillastnight.Now,Ican'tforthelifeofmegetittowork.
W:You'llneverbeabletogetsparepartsforit.Itmightbetimetoinvestinamorerecentmodel.
Q:Whatcanbeinferredfromtheconversationaboutthewashingmachine?
(16)
A.Itshouldhavelastedlonger.
B.Themanshouldbuynewpartsforit.
C.Themanshouldconsiderbuyinganewone.
D.Itwasn'tagoodinvestment.
30.(39)
31.【B8】
32.
【B7】
33.(25)
A.TheywillgototheGrill.
B.Theywillgotothelibrary.
C.Theywillgoswimming.
D.Theywillwalkhome.
34.(35)
A.Hoodsoftentakeplaceafterearthquakes.
B.Slidesoftentakeplaceafterearthquakes.
C.Slidesdonotoftentakeplaceafterearthquakes.
D.Disastersoftentakeplaceafterearthquake.
35.(22)
A.ItisconvenienttotravelinLondonbyunderground.
B.BanksareopenforthewholeweekexceptonSaturday.
C.Englishfoodisverydelicious.
D.Britishpeoplearefriendlytostrangers.
36.聽力原文:M:Thebook'sbeensellinglikehotcakessinceitwaslaunchedthreeweeksago.
W:Iunderstandthey'llberunningasecondprintsoon.AndIwillgogetoneatthecampusbookstorethisWednesday.Wouldyougowithmethen?
Q:Whatdowelearnaboutthebookfromtheconversation?
(17)
A.Itisverypopular.
B.ItwillbelaunchedthisWednesday.
C.It'snotsoldatthecampusbookstore.
D.Itranasecondprintthreeweeksago.
37.(33)
A.TointroducethecategoriesofbooksintheUSlibraries.
B.ToexplainrolesofdifferentUSlibraries.
C.TodefinethecirculationsystemofUSlibraries.
D.TodemonstratetheimportanceofUSlibraries.
38.聽力原文:W:OurEnglishteachertoldmethatthefinalexamwouldcoverthefirsttenUnitsoutofthetotaltwenty.
M:Really?IthoughtitwouldonlyincludethelastfourUnits.ThenImustspendthenextweektofinishthelessonswewillbeexamined.
Q:HowmanyUnitsmustthemanreviewnextweek?
(13)
A.SixUnits.B.FourteenUnits.C.SixteenUnits.D.TenUnits.
39.聽力原文:W:Iamsoexcitedjusttothinkaboutit!ThisismyfirsttriptoParis.Iwanttovisitalltheinterestingplacesthere.ButIamafraidthatIcan'tfindmywayaroundthere.
M:Don'tworryaboutthat.Justgivemeacallwhenyouhavetrouble.I'llbegladtoshowyouaround.Iamsofamiliarwiththeseplaces.
Q:Whatdoesthemanoffertodoforthewoman?
(18)
A.TotakehertoParis.
B.Toshowherwhattheinterestingplacesare.
C.Toserveasherguide.
D.Tointroducehertohisfamilies.
40.聽力原文:Paces,likefingerprints,areunique.DidyoueverwonderhowitispossibleforustorecognizepeopleEvenaskilledwriterprobablycouldnotdescribeallthefeaturesthatmakeonefacedifferentfromanother.Yetaveryyoungchildorevenananimal,suchasapigeoncanlearntorecognizefaces.Wealltakethisabilityforgranted.Wealsotellpeopleapartbybowtheybehave.Whenwetalkaboutsomeone'spersonality,wemeanthewaysinwhichheorsheacts,speaks,thinksandfeelsthatmakethatindividualdifferentfromothers.
Likethehumanface,humanpersonalityisverycomplex.Butdescribingsomeone'spersonalityinwordsissomewhateasierthandescribinghisface.Ifyouwereaskedtodescribewhata"niceface"lookedlike,youprobablywouldhaveadifficulttimedoingso.Butifyouwereaskedtodescribea"niceperson,"youmightbegintothinkaboutsomeonewhowaskind,considerate,friendly,warmhearted,andsoon.Therearemanywordstodescribehowapersonthinks,feelsandacts.AnAmericanpsychologistfoundnearly18,000Englishwordscharacterizingdifferencesinpeople'sbehavior.Andmanyofususethisinformationasabasisfordescribing,ortypinghispersonality.Bookworms,conservatives,militarytypes:peoplearedescribedwithsuchterms.
Peoplehavealwaystriedto"type"eachother.ActorsinearlyGreekdramaworemaskstoshowtheaudiencewhethertheyplayedthevillains'ortheheroes'role.Infact,thewords"person"and"personality"comefromLatin,meaning"mask".Today,mosttelevisionandmovieactorsdonotwearmasks.Butwecaneasilytellthe"goodguys"fromthe"badguys'becausethetwotypesdifferinappearanceaswellasinactions.
(33)
A.Howtodistinguishpeople'sfaces.
B.Howtodescribepeople'spersonality.
C.Howtodistinguishpeoplebothinwardandoutward.
D.Howtodiffergoodpersonsfrombadpersons.
三、4.ReadingComprehension(ReadinginDepth)(20題)41.SectionB
Directions:Thereare2passagesinthissection.Eachpassageisfollowedbysomequestionsorunfinishedstatements.ForeachofthemtherearefourchoicesmarkedA,B,CandD.Youshoulddecideonthebestchoice.
Over-cultivationandalongperiodofsoilerosionhadreducedthefertilityofmuchoftheUnitedStates'farmland.Forestshadbeencutorburnedtoprovideadditionalcropland.Inthemid1930s,aseriesofdryyearsresultedinextremecroplossesintheMidwest.ThewindsoftheGreatPlainscausedhugeduststormsonovergrazed(過度放牧的)lands.
Tomeetthischallengeaphilosophyoflanduseandconservationbegantodevelop.Governmentbureausbelievedfarmersneededtobeencouragedandeducatedonthevaluesofbetterland-usepractices.Theindependent-mindedfarmerssometimesfoundithardtoacceptthatsomeoneelseknewtheirbusinessbetterthantheydid,orthattheyshouldthinkintermsoflongrangeself-interestratherthannextyear'scrop.Governmentconservationagentswereemployedtodemonstratebettertechniques,andwhenfarmerssawthattheirneighborswhousednewmethodswereprospering,theybegantoadoptthenewmethods.Further,governmentincentiveswereofferedintheform.offreeserviceorevencashpaymenttoimprovetheirland.
Inthe1920s,demandforAmericanfarmproductsfell,asEuropeancountriesbegantorecoverfromWorldWarIandinstitutedausterity(緊縮)programstoreducetheirimports.Theresultwasasharpdropinfarmprices.Thisperiodwasmoredisastrousforfarmersthanearliertimeshadbeen,becausefarmerswerenolongerself-sufficient.Theywerepayingformachinery,seed,andfertilizer,andtheywerealsobuyingconsumergoods.Thepricesoftheitemsfarmersboughtremainedconstant,whilepricestheyreceivedfortheirproductsfell.ThesedevelopmentsweremadeworsebytheGreatDepression,whichbeganin1929andextendedthroughoutthe1930s.
In1929,theFederalFarmBoardwasorganized.Itestablishedtheprincipleofdirectinterferencewithsupplyanddemand,andrepresentedthefirstnationalcommitmenttoprovidegreatereconomicstabilityforfarmers.
OneofthefirstmeasuresproposedbyPresidentFranklinD.Rooseveltwhenhetookofficein1933wastheAgriculturalAdjustmentAct,whichwassubsequentlyenactedbyCongress.ThislawgavetheSecretaryofAgriculturethepowertoreduceproductionthroughvoluntaryagreementswithfarmerswhowerepaidtotaketheirlandoutofuse.Adeliberatescarcityoffarmproductswasplannedinanefforttoraiseprices.ThislawwasdeclaredunconstitutionalbytheSupremeCourtonthegroundsthatgeneraltaxeswerebeingleviedtopayonespecialgroupofpeople.However,newlawswerepassedimmediatelythatachievedthesameresultofrestingsoilandprovidingflood-controlmeasures,butwhichwerebasedontheprincipleofsoilconservation.TheRooseveltAdministrationbelievedthatrebuildingthenation'ssoilwasinthenationalinterestandwasnotsimplyaplantohelpfarmersattheexpenseofothercitizens.
Accordingtothepassage,Americanfarmers______.
A.knewtheirbusinessbetterthananyoneelse
B.usuallycaredmoreabouttheirshort-terminterest
C.readilyadoptedbetteragriculturaltechniques
D.realizedthevaluesofbetterlandusebythemselves
42.
TothecountriesinSoutheastAsia,buildingatsunamimonitoringsystem
43.
Whichofthefollowinggroupswouldbemostconcernedwiththeissuesraisedbytheauthor?
A.Electricians.B.Environmentalists.C.Aviators.D.Teachers.
44.
Weknowfromthefirstparagraphthatpeopleinoldtimes______.
A.weremoreenthusiasticaboutthedevelopmentofscienceandtechnology
B.hadastrongersenseofbeauty
C.over-dependentonlaborsavingdevices
D.paidmoreattentiontomaterialbenefits
45.
WhatmakestheAmericandeliberatelyunhappyaccordingtotheauthor?
46.SectionA
Directions:Inthissection,thereisashortpassagewith5questionsorincompletestatements.Readthepassagecarefully.Thenanswerthequestionsorcompletethestatementsinthefewestpossiblewords.
Scientistssaytheyhavehighhopesforadrugthatcouldonedayprovideanewform.oftreatmentforH1V-AIDS.Acompound,whichinterfereswithanelusiveproteinusedbytheHIVvirustoinfecthumancells,hasworkedextremelywellinmonkeys,Ifthe.drugproveseffectiveinhumantrials,scientistssay,itcouldbolster(加強)theeffectivenessoftwoexistingAIDSdrugs,particularlyinfightingdrug-resistantstrainsofthevirus.
Researchersatthepharmaceutical(制藥的)companyMerckareveryexcitedaboutanexperimentaldrug,whichhasworkedaswellinmonkeysinfectedwithaprimateversionofthevirusasanyoftheexistinganti-AIDSdrugs.
Itworksbyblockingoneofthreeproteins,orenzymes,theHIVvirususestogainentranceintoandinfecthumanimmunesystemcells.
Inhibitordrugshavebeendevelopedtoblocktwooftheproteins,toslowprogressionofthediseaseafterinfection.Theyhavebecomestandardtherapyasa"cocktail"forpeopleinfectedwithHIV.
Thoseenzymeserereversetranscriptase(轉錄酶)andprotease(蛋白酶).Thefirstconvertsthevirus'geneticmaterialintothatofitshostcells.Thesecondchopsuptheresultinglargerproteinsintosmallerpieces,producingsmallerviralparticlesthatinfectnewcells.
Thethirdprongofcellularattackisaproteincalledintegrase(整合酶),whichexpertssayhasbeenhardertoblock.OnceHIVfoolshostcellsbychangingitsgeneticinformationsoitcanenterthem,integraseactslikeacutandpasteoperationinawordprocessor,deletinganimmunecell'sgeneticmaterialandreplacingitwithitsown.
AnintegraseinhibitorwouldgivedoctorsathirdlineofattackagainstHIVinfection,accordingtovirologistDariaHazudaofthedivisionofVirusandCellBiologyatMerck.
"Thiswouldofferathirdclassofanti-retroviralmedicationsthatcanbecombinedwithreversetranscriptaseinhibitorsandproteaseinhibitors.Andsinceitisanewmechanismofaction,thesecompoundsareactiveagainstmulti-drugresistantvariants.SovariantsthatareresistanttoallcurrenttherapieshavebeenselectedinHIV-patients,"shesaid.
Currentanti-AIDSdrugseventuallybecomeresistanttotherapy,orstopworking,becausetheviruschangesitsshape.
Whileresearchersareencouragedbythesuccesswiththecompound'seffectivenessinmonkeytrials,developingadrugthatisequallyeffectiveinhumanscanbedifficult.
StevenYoungisexecutivedirectoroftheDepartmentofMedicinalChemistryatMerck.Hesays,ifscientistsfindacompoundthatisequallyeffectiveinpeople,thecompanywouldaskU.S.regulatorstospeedapprovalofthedrug.
"Yeah,Ireallythinkthat'swhatwe'rehopingfor,"hesaid."Imean,weneedtogetdatathatshowithasrobustanti-viraleffectsinpeople.Andifwe'reabletogetthatdata,Ithinkwewouldpetitionforfasttrackstatus."
Dr.Youngsaysanintegraseinhibitorhasthepotentialtopreventdrugresistance.
"Toensureourbestchancesofpreventingresistance,wewouldgivethisaspartofacocktailtherapy,"headded."AndIthinkit'sreallyourplanthatwewouldtestthiswithreversetranscriptaseinhibitorsandproteaseinhibitors,aswell."
Ifthedrugproveseffectiveinhumantrials,itcouldenhancetheeffectivenessofexistingAIDSdrugsin______.
47.
Anassistantstagemanager'sjobisdifficultbecausehehasto______.
A.doallkindsofstagework
B.workforlonghours
C.waitforabettercompany
D.actwell
48.
Itcanbeinferredfromthepassagethattheauthormainlyconcernsthat______.
A.femaleleaderscanchangethecourseofourpoliticalandeconomicfuture
B.whowillbenefitmostwhenthepoliticalpoweriscontrolledbywomen
C.whythepoliticalleadershipofwomenisonekindofworldcrises
D.thewaysinwhichwomencanobtaintheleadershipinthefuture
49.Movingfarmorequicklythanmanyhadthoughtlikelyorpossible,lawmakersinthe10-memberHouse-Senatecommitteeannouncedtheagreementafterlessthan24hoursofnegotiations.
SenateMajorityLeaderHarryReid:"Likeanynegotiation,thisinvolvedgiveandtake,andifyoudon'tmindmysayingsothatisanunderstatement."
Theagreementdropsthetotalto$789billion,whilebothSenateandHouse-passedmeasuresexceeded$800billion.
Acombinationoflowandmiddleincometaxcuts,makingupabout35percentofthebill,anddomesticspending,itssupporterssayitmeetsPresidentBarackObama'sgoalofcreatingorsavingasmanyas4millionjobs.
SusanCollinsofMainewasamongonly3moderateSenateRepublicanswhojoinedtheDemocraticmaj
溫馨提示
- 1. 本站所有資源如無特殊說明,都需要本地電腦安裝OFFICE2007和PDF閱讀器。圖紙軟件為CAD,CAXA,PROE,UG,SolidWorks等.壓縮文件請下載最新的WinRAR軟件解壓。
- 2. 本站的文檔不包含任何第三方提供的附件圖紙等,如果需要附件,請聯(lián)系上傳者。文件的所有權益歸上傳用戶所有。
- 3. 本站RAR壓縮包中若帶圖紙,網頁內容里面會有圖紙預覽,若沒有圖紙預覽就沒有圖紙。
- 4. 未經權益所有人同意不得將文件中的內容挪作商業(yè)或盈利用途。
- 5. 人人文庫網僅提供信息存儲空間,僅對用戶上傳內容的表現方式做保護處理,對用戶上傳分享的文檔內容本身不做任何修改或編輯,并不能對任何下載內容負責。
- 6. 下載文件中如有侵權或不適當內容,請與我們聯(lián)系,我們立即糾正。
- 7. 本站不保證下載資源的準確性、安全性和完整性, 同時也不承擔用戶因使用這些下載資源對自己和他人造成任何形式的傷害或損失。
最新文檔
- 智慧城市服務公司合并合同(2篇)
- 機場地勤招聘中介合同(2篇)
- 交通安全風險評估-第2篇-深度研究
- 智能客服技術應用-第1篇-深度研究
- 二零二五年度2025年反壟斷法律援助委托代理合同
- 2025年度輕傷害事故賠償和解及長期護理服務合同
- 2025年度醫(yī)院醫(yī)生個人醫(yī)療咨詢服務合同
- 2025年倉庫出租合同的損害賠償標準
- 2025年《產品市場推廣合同》
- 2025年照明技術專利實施許可合同
- 2025年合資經營印刷煙包盒行業(yè)深度研究分析報告
- 天津市五區(qū)縣重點校2024-2025學年高一上學期1月期末聯(lián)考試題 化學 含答案
- 吉林省吉林市普通中學2024-2025學年高三上學期二模試題 生物 含答案
- 2025年湖南省通信產業(yè)服務限公司春季校園招聘76人高頻重點提升(共500題)附帶答案詳解
- 《電影之創(chuàng)戰(zhàn)紀》課件
- 2024-2025學年人教版五年級(上)英語寒假作業(yè)(一)
- 開題報告-鑄牢中華民族共同體意識的學校教育研究
- 浙江省五校鎮(zhèn)海中學2025屆高考考前模擬數學試題含解析
- 公司2025年會暨員工團隊頒獎盛典攜手同行共創(chuàng)未來模板
- 新滬科版八年級物理第三章光的世界各個章節(jié)測試試題(含答案)
- 人教版五年級上冊四則混合運算300道及答案
評論
0/150
提交評論