Tubulin-inhibitor-40-DataSheet-生命科學試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemETubulininhibitor40Cat.No.:HY-163195分?式:C??H??N?O?分?量:356.37作?靶點:Microtubule/Tubulin作?通路:CellCycle/DNADamage;Cytoskeleton儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Tubulininhibitor40（compound45）?種Tubulin抑制劑，IC50值1.2μM。Tubulininhibitor40對癌細胞具有選擇性的細胞毒性。Tubulininhibitor40具有抗腫瘤活性[1]。IC50&Target0.005μM(Tubulin,A549),0.008μM(Tubulin,VA13),0.009μM(Tubulin,MCF7’),0.008μM(Tubulin,HEK293T)[1]體外研究Tubulininhibitor40revealscytotoxicitytowardscelllinesA549,VA13,MCF7’andHEK293T,withIC50valuesof0.005μM,0.008μM,0.009μMand0.008μM,respectively[1].Tubulininhibitor40inhibitstubulinpolymerizationwithIC50of1.2μM[1].Tubulininhibitor40(1-25μM,24h)causeschangesincellmorphologyandtubulinassemblyinA549[1].CellCytotoxicityAssay[1]CellLine:A549,VA13,MCF7’,HEK293TConcentration:arangeofconcentrationsfromafewnMto100μMIncubationTime:72hResult:ShowedcytotoxicitytowardscelllinesA549,VA13,MCF7’andHEK293T.體內研究Tubulininhibitor40(i.v.,20mg/kg,5days)processesantitumoractivity[1].AnimalModel:antitumorefficacyinmurineL1210andP388leukemiainBALB/cnudemice[1]1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEDosage:20mg/kg,i.v.,5daysAdministration:intravenousinjectionResult:ShowedT/Cvaluesof233%and324%forP388andL1210leukemia.AnimalModel:AntitumorEfficacyinHumanCancerXenografts.SW620inBALB/cnudemice[1]Dosage:20mg/kg,i.v.,5daysAdministration:i.v..intravenousinjectionResult:Reducedtumorgrowthby74%.REFERENCES[1].GeorgyLetal.,3,4-Diarylisoxazoles─AnaloguesofCombretastatinA-4:Design,Synthesis,andBiologicalEvaluationInVitroandInVivo.ACSPharmacology&TranslationalScienceArticleASAP,January16,2024McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400