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ImmunoregulationGuangjieChenDept.ofImmunologyandMicrobiology2014ImmunoregulationGuangjieChenImmunefunctions:ImmunedefenseImmunehomeostasis----immunologicaltoleranceandimmunoregulationImmunesurveillance

Immunefunctions:Immunoregulation:positiveandnegativedirectionLevels:molecularlevel,cellularlevel,holisticlevelandpopulationlevelImmunoregulation:positiveaI.ImmunoregulationistheabilityofimmunesystemitselfSenseandimmunoregulationI.ImmunoregulationistheabantigenTiterofAbDaysafterimmunizationtestcontrolExchangeserumfromanotherrabbitwithoutimmunizationantigenTiterofAbDaysafteri2.Responseandimmunoregulation

negative

feedbackregulationisthemainstream3.Immunoregulation

andintervention4.Immunoregulation

and

diseases：SARS2.ResponseandimmunoregulatiII.Immunoregulationininnateimmuneresponse1.ImmunologicalregulationinTLRmediatedresponse

TLR—PAMP：NF-kB，MAPKpathway---inflammatorygeneactivated，inflammatoryresponseeliminatepathogensII.Immunoregulationininnate《雨鈴鐺》PPT【精美版】timeofinflammatoryresponseEarlyLaterIntensityofresponseStageofeffectMaintainsuitableintensityStageoftoleranceNoreactivityinhibitorysignalinhibitorysignal

stimulatingsignal

timeofinflammatoryresponseE2.SOCS(suppressorofcytokinesignaling)

CK-CKR------signaltransduction----targetgeneactivated

SOCS

geneactivated,inducenegativefeedback2.SOCS(suppressorofcytokin《雨鈴鐺》PPT【精美版】3.Regulatoryproteinofcomplement

C1INH:inhibitclassicalpathway

CD55(DAF),CR1:inhibitingformationofCconvertase

CD59:inhibitingformationofMAC3.RegulatoryproteinofcomplIII.Inhibitoryreceptormediatedimmunoregulation1.Immunoregulationbytransductionsignal

（1）PTK,PTPPTK

PTP

III.Inhibitoryreceptormedi（2）ITAMandITIMITAMCD3、Ig

、Ig

、FcRIITIM

CTLA-4、FcRIIB、KIR（2）ITAMandITIMITAM:twoYxxL/Vconservedsequence：Y--tyrosine，L—leucine，V—valineY-phosphorylation,binewithcytoplasmicPTK(ZAP-70），transductionTCRacceptableantigenstimulationsignalITAM:ITIM:I/VxYxxL：I—isoleucine

Y—phosphorylation,bindtoSHP-1andSHIP，inhibitthetransductionsignalofTcellactivationITIM:ActivationsignalsInhibitorysignalsActivationsignalsInhibitory2.Immunoregulationbyinhibitoryreceptors

（1）co-stimulatorymoleculesCD28-----B7：activationCTLA-4-----B7：inhibition（after24h）PD-1-------PD-L1/2：inhibition*Noactivationthereisnoinhibition2.Immunoregulationbyinhibitactivationinhibitionactivationinhibition《雨鈴鐺》PPT【精美版】（2）FcRIIb(Bcells)

（2）FcRIIb(Bcells)（3）InhibitoryreceptorsofNKcellInhibitoryreceptorsandtheirligandsactivatingreceptorsandtheirligands（3）InhibitoryreceptorsofNKIV.ImmunoregulationbyregulatoryTcellcharacteristicsnTregiTregInductionsitethymuspheripheralCD25

expression+++-/+Foxp3++++Ag-specificAuto-antigen(thymus)Tissue-specificantigenandforeignantigeneffectCell-cellcontact,cytokineproductionCytokinedependentfunctionInhibitionofauto-reactiveTcellimmuneresponseInhibitionofauto-reactiveinflammationandgraftrejection,benefitforcancerIV.Immunoregulationbyregul《雨鈴鐺》PPT【精美版】iTreg:Th3：TGF-

Tr1：IL-10iTreg:《雨鈴鐺》PPT【精美版】《雨鈴鐺》PPT【精美版】V.Regulationbyidiotypeandanti-idiotypenetworkAb（Id）——AIdV.RegulationbyidiotypeandImmunogenicityofimmunoglublinImmunogenicityofimmunoglublsuppressAb1：treatmentofautoimmunediseasesAntigenicinternalimageenhanceAb1：treatmentofAIDSandtumorIdiotypeandanti-idiotypenetworksuppressAb1：treatmentofaut《雨鈴鐺》PPT【精美版】《雨鈴鐺》PPT【精美版】TcellsTcelllinesExpansionTcelllinesIrradiation1stinjection2ndinjection3rdinjection1months1monthTcellsTcelllinesExpansionTIdiotypiccellAnti-idiotypiccellinducecytotoxcity

IdiotypenetworksIdiotypiccellAnti-idiotypiccIdiotypenetworksinducedbyTcellvaccineMonths

CD8+granzyme-BsecretingTcells******Positivecells/106purifiedTcellsIdiotypiccellAnti-idiotypiccellinducecytotoxcity

IdiotypenetworksinducedbyTVI.ImmunoregulationbyAICDActivationinducedcelldeathFasL-Fas（apoptosis）VI.ImmunoregulationbyAICDA《雨鈴鐺》PPT【精美版】《雨鈴鐺》PPT【精美版】AutoantigensAutoantigeninducedTcellexpansionAutoimmunelymphoproliferativesyndrome,ALPSAutoantigensAutoantigeninduceVI.EffectsoftheneuroendocrinesystemonimmunesystemVI.Effectsoftheneuroendocr《雨鈴鐺》PPT【精美版】《雨鈴鐺》PPT

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