免疫細胞培養(yǎng)細胞因子

免疫細胞培養(yǎng)細胞因子支持多種免疫細胞培養(yǎng)低內(nèi)毒素高純度、高活性、高批間一致性GMP級、無動物源細胞因子可供選擇高品質(zhì)細胞因子T細胞培養(yǎng)更多免疫細胞培養(yǎng)相關(guān)產(chǎn)品GMP級CD3

(OKT3)/CD28激活抗體CAR-T/CAR-NK細胞檢測流式抗體細胞因子檢測ELISA試劑盒P

04

自然殺傷（NK）細胞培養(yǎng)目錄樹突狀（DC）細胞培養(yǎng)P

08

B細胞培養(yǎng)單核/巨噬細胞培養(yǎng)P

10

粒細胞培養(yǎng)P

01P

02P

06P

09P

1

1免疫細胞培養(yǎng)細胞因子北京義翹神州科技股份有限公司免疫細胞培養(yǎng)細胞因子01高品質(zhì)細胞因子近年來，過繼性免疫細胞治療已成為腫瘤免疫療法的研究熱點，包括CAR-M、CAR-NK、CAR-T、TCR-T、NK、DC、CIK等。細胞因子能夠調(diào)節(jié)免疫細胞的增殖與分化、信號轉(zhuǎn)導(dǎo)等，是免疫細胞培養(yǎng)、細胞與基因治療藥物（CGT）開發(fā)過程中所必需的試劑。義翹神州致力于免疫細胞治療相關(guān)研究，自主研發(fā)并建立了重組蛋白生產(chǎn)平臺、抗體開發(fā)平臺、嚴謹?shù)馁|(zhì)量控制檢測平臺以及GMP質(zhì)量管理體系，開發(fā)了一系列高品質(zhì)細胞因子，具有高活性、低內(nèi)毒素、高批間一致性和高純度等特點，以支持免疫細胞培養(yǎng)、免疫細胞療法、藥物研發(fā)和疫苗開發(fā)等研究，全面助力細胞治療的開發(fā)進程。另有GMP級、無動物源細胞因子可供選擇！支持多種免疫細胞培養(yǎng)高純度、高活性和高批間一致性低內(nèi)毒素無標簽或小標簽表達GMP級、無動物源細胞因子可供選擇純度經(jīng)SDS/SEC-HPLC驗證生物活性經(jīng)細胞水平驗證完善的質(zhì)量控制體系產(chǎn)品特點資質(zhì)證書2024年值得關(guān)注的生長因子供應(yīng)商CNAS證書FDA

DMF備案ISO

9001:2015證書ISO

13485:2016證書GMP證書北京義翹神州科技股份有限公司02免疫細胞培養(yǎng)細胞因子CAR-T和腫瘤浸潤淋巴細胞療法等T細胞介導(dǎo)的癌癥療法的進步為癌癥治療開辟了新的可能性。IL-2是一種常用于T細胞培養(yǎng)的有效細胞因子，以促進效應(yīng)T細胞和記憶T細胞的增殖和分化。IL-4、IL-7、IL-15和IL-21在記憶T細胞的形成、增殖和存活中發(fā)揮重要的作用。產(chǎn)品數(shù)據(jù)展示GMP-grade

Human

IL-21

(Cat#:

GMP-10584-HNAE)高純度

高活性

經(jīng)HPLC驗證低內(nèi)毒素高批間一致性Na?veGata3IL-15NKTRorγtFoxp3Stat6Gata3TbetBcl6IL-6,

IL-21TFHIFNγTNF

αIL-10TGF

βIL-9IL-4IFNγ抗病毒IL-17IL-21TNF

α抵御胞外細菌免疫調(diào)節(jié)抗腫瘤防御過敏和哮喘抵御細胞內(nèi)病原體IL6IL-21TGF

β抵御自身免疫TGF

β+IL-6Th17TGF

β+IL-2TregTGF

β+IL-4Th9IL-4Th2IL-12Th1Na?ve

T細胞分化為不同T細胞亞群相關(guān)的細胞因子義翹神州致力于開發(fā)應(yīng)用于CAR-T細胞療法的高質(zhì)量試劑產(chǎn)品，嚴格遵循質(zhì)量管理體系和藥品級放行檢測標準，藥品級生產(chǎn)環(huán)境及生產(chǎn)管理，成功開發(fā)了一系列如IL-2、IL-7、IL-15和IL-21等高質(zhì)量的GMP級細胞因子，助力T細胞培養(yǎng)和細胞治療藥物研發(fā)。16001400120010008006004002000Conc

of

SecretionIFN-γ.(pg/ml)Competitor

R

Sinobiological1E-3

0.01

0.1

1

10

100Human

IL-21

Conc.

(ng/mL)Induced

Interferon

gamma

secretion

byhuman

natural

killer

lymphoma

NK-92

cellsThree

and

five

cycles

of

freeze-thaw

testswere

conducted

to

verify

GMP-gradehuman

IL-21

stability.1E-3

0.01

0.1

1

10

100Human

IL-21

Conc.

(ng/mL)16001400120010008006004002000-200Conc

of

SecretionIFN-γ.(pg/ml)凍融0次凍融3次凍融5次T細胞培養(yǎng)Two

independentlots

ofGMP-gradehuman

IL-21

showed

identical

bioactivity.1E-3

0.01

0.1

1

1010016001400120010008006004002000Conc

of

Secretion

IFN-r.

(pg/mL)Human

IL-21Conc.(ng/mL)Batch

1Batch

2北京義翹神州科技股份有限公司免疫細胞培養(yǎng)細胞因子03HPLC-VerifiedAnimal-FreeGMP-Grade

AvailableT細胞培養(yǎng)細胞因子推薦細胞因子貨號種屬表達宿主純度內(nèi)毒素B7-H2/ICOSLG11559-HNAHHumanHEK293

Cells≥

95%<

1.0

EU/μgBMP410609-HNAE2HumanE.

coli≥

95%<

1.0

EU/μgbasic

FGF/FGF210014-HNAEHumanE.

coli≥

95%<

10

EU/mgGMP-10014-HNAEHumanE.

coli≥

95%<

10

EU/mgFlt3

Ligand/FLT3LG10315-HNAEHumanE.

coli≥

95%<

10

EU/mgGMP-10315-HNAE1-L-AFHumanE.

coli≥

95%<

10

EU/mgIFN

gamma11725-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-11725-HNAEHumanE.

coli≥

95%<

5

EU/mgIL-1

beta10139-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-10139-HNAEHumanE.

coli≥

95%<

5

EU/mgIL-211848-HNAE2HumanE.

coli>

95%<

5

EU/mgGMP-11848-HNAEHumanE.

coli≥

95%<

5

EU/mgIL-411846-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-11846-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-11846-HNAE-LHumanE.

coli≥

95%<

10

EU/mgIL-610395-HNAEHumanE.

coli≥

95%<

10

EU/mgGMP-10395-HNAEHumanE.

coli≥

95%<

5

EU/mgIL-711821-HNAEHumanE.

coli≥

95%<

10

EU/mgGMP-11821-HNAEHumanE.

coli≥

95%<

10

EU/mgIL-12CT011-H08HHumanHEK293

Cells≥

95%<

5

EU/mgGMP-CT011-H08HHumanHEK293

Cells≥

95%<

5

EU/mgIL-1510360-HNCEHumanE.

coli≥

95%<20

EU/mgGMP-10360-HNCEHumanE.

coli≥

95%<

5

EU/mgIL-1810119-HNCEHumanE.

coli>

95%<

10

EU/mgIL-2110584-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-10584-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-10584-HNAE1-L-AFHumanE.

coli≥

95%<

10

EU/mgIL-23CT048-H08HHumanHEK293

Cells>

90%<

1.0

EU/μgSCF10451-HNAEHumanE.

coli≥

95%<

10

EU/mgGMP-10451-HNAE1-L-AFHumanE.

coli≥

95%<

10

EU/mgTGF

beta

110804-HNACHuman,

Rhesus,Cynomolgus,

CanineCHO

Stable

Cells>

95%<

1.0

EU/μg10804-H08HHumanHEK293

Cells>

95%<

1.0

EU/μgTGF-beta

3/TGFB310434-H01HHumanHEK293

Cells>

90%<

1.0

EU/μgTNF-alpha10602-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-10602-HNAEHumanE.

coli≥

95%<

5

EU/mgThrombopoietin10381-H07HHumanHEK293

Cells>

90%<

1.0

EU/μg北京義翹神州科技股份有限公司04免疫細胞培養(yǎng)細胞因子自然殺傷細胞分化與培養(yǎng)相關(guān)的細胞因子自然殺傷（NK）細胞是具有高度細胞毒性的非特異性免疫效應(yīng)細胞，可殺死被病原體感染的細胞和癌細胞，并釋放細胞因子，招募其他免疫細胞共同發(fā)揮作用。CAR-NK細胞療法在血液瘤和實體瘤的治療中具有顯著的效果。與CAR-T療法相比，CAR-NK細胞療法更安全。細胞因子對于NK細胞的發(fā)育和存活具有重要調(diào)節(jié)作用。如IL-21能誘導(dǎo)NK細胞的成熟，并增強其細胞毒性。義翹神州成功開發(fā)出高質(zhì)量、高活性的細胞因子，如IL-2、IL-7、IL-12、IL-15和IL-21等助力NK細胞培養(yǎng)和CAR-NK細胞治療藥物研發(fā)。自然殺傷（NK）細胞培養(yǎng)HSCCLPNKPiNKmNKCytotoxicTolerantRegulatoryKL,

FL,

IL-3,

IL-7KL,

FL,

IL-15IL-15IL-15IL-2/IL-15IL-12/IL-18/IL-21TGF-β

IL-10TGFβ/IL-15應(yīng)用案例展示NK細胞分化HumanIL-2,

IL-15,

and

IL-21

(Cat#:

11848-HNAH1-E;

Cat#:

10360-HNCE;

Cat#:

10584-HNAE)Medium

IL-2

IL-15

IL-21CD3-

CD56

dim

CD3-

CD56

bright3.52

0.63CD3-

CD56

dim

CD3-

CD56

bright5.43

1.16CD3-

CD56

dim

CD3-

CD56

bright6.59

1.24CD3-

CD56

dim

CD3-

CD56

bright6.02

0.87IL-2

+

IL-15IL-2

+

IL-21IL-15

+

IL-21UnstainedCD3-

CD56

dim

CD3-

CD56

bright5.45

0.94CD3-

CD56

dim

CD3-

CD56

bright6.65

1.56CD3-

CD56

dim

CD3-

CD56

bright7.61

1.11CD3-

CD56

dim

CD3-

CD56

bright0.068

0.011CD3CD56Natural

killer

(NK)

cells

expansion

was

detected

by

FACS

analysis.Representative

graphs

of

CD3?CD56+

(CD56bright

and

CD56dim)

expressing

cells

demonstrated

3-day

treatment

of

γccytokine

(20

ng/mL

IL-2,

20

ng/mL

IL-15,

and

25

ng/mL

IL-21)

induced

NK

cells

expansion.DOI:

10.1155/2023/8924603北京義翹神州科技股份有限公司免疫細胞培養(yǎng)細胞因子05細胞因子貨號種屬表達宿主純度內(nèi)毒素BMP410609-HNAE2HumanE.

coli≥

95%<

1.0

EU/μgFlt3

Ligand/FLT3LG10315-HNAEHumanE.

coli≥

95%<

10

EU/mgGMP-10315-HNAE1-L-AFHumanE.

coli≥

95%<

10

EU/mgIFN

gamma11725-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-11725-HNAEHumanE.

coli≥

95%<

5

EU/mgIL-211848-HNAE2HumanE.

coli>

95%<

5

EU/mgGMP-11848-HNAEHumanE.

coli≥

95%<

5

EU/mgIL-311858-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-11858-HNAEHumanE.

coli≥

95%<

5

EU/mgIL-711821-HNAEHumanE.

coli≥

95%<

10

EU/mgGMP-11821-HNAEHumanE.

coli≥

95%<

10

EU/mgIL-12CT011-H08HHumanHEK293

Cells≥

95%<

5

EU/mgGMP-CT011-H08HHumanHEK293

Cells≥

95%<

5

EU/mgIL-1510360-HNCEHumanE.

coli≥

95%<20

EU/mgGMP-10360-HNCEHumanE.

coli≥

95%<

5

EU/mgIL-1810119-HNCEHumanE.

coli>

95%<

10

EU/mgIL-2110584-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-10584-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-10584-HNAE1-L-AFHumanE.

coli≥

95%<

10

EU/mgSCF10451-HNAEHumanE.

coli≥

95%<

10

EU/mgGMP-10451-HNAE1-L-AFHumanE.

coli≥

95%<

10

EU/mgVEGF16511066-HNAHHuman,

CynomolgusHEK293

Cells≥

95%<

10

EU/mg產(chǎn)品數(shù)據(jù)展示NK細胞培養(yǎng)細胞因子推薦經(jīng)HPLC驗證高活性高純度GMP-grade

Human

IL-2(Cat#:

GMP-11848-HNAE)GMP-grade

Human

IL-15(Cat#:

GMP-10360-HNCE)低內(nèi)毒素高批間一致性Cell

proliferation

assay

using

CTLL2.

The

specific

activity

ofrecombinant

human

IL-2

is

approximately

20,000

IU/μg0.1600

ED50=1-8

ng/mL5004003002001000-100Proliferation,

%1

10Human

IL-2

Conc.

(ng/mL)ED50=0.5-5

ng/mL0.01

0.1

1

10

100-5000Human

IL-15Conc.

(ng/mL)Measuredin

a

cell

proliferationassay

usingMO7e

humanmegakaryocytic

leukemic

cells.300002500020000150001000050000Proliferation,%HPLC-VerifiedAnimal-FreeGMP-Grade

Available06免疫細胞培養(yǎng)細胞因子樹突狀細胞分化與發(fā)育相關(guān)的細胞因子義翹神州開發(fā)了一系列高純度、高生物活性、低內(nèi)毒素的高品質(zhì)細胞因子，全面支持DC細胞培養(yǎng)、DC疫苗開發(fā)和免疫細胞治療等研究。樹突狀細胞（DC）是已知功能最強的功能性抗原提呈細胞，可激活CD4+輔助T細胞和CD8+細胞毒性T細胞。成熟的DC細胞抗原提呈能力和啟動免疫應(yīng)答能力增強，可分泌細胞因子刺激T淋巴細胞發(fā)揮免疫效應(yīng)。利用GM-CSF和IL-4誘導(dǎo)可在體外得到未成熟的DC細胞，再加入TNF-α進行體外誘導(dǎo)培養(yǎng)，即可得到成熟的DC細胞。樹突狀（DC）細胞培養(yǎng)SCFM-CSFSCFFLT3LGM-CSF,

IL-4TNF-a,

IL-6,

IL-1β,

IFN-γGM-CSF,

IL-4FLT3LIL-3GM-CSF,

IL-4HSCMyeloid

precursorMonocyteCDPLymphoid

precursor

Plasmacytic

cellpre-cDCPlasmacytoid

DCMature

DCcDC1cDC2Immature

DCMature

monocyte-drived

DC外周血PBMC101

102

103

104

105

106

1074.0K3.0K2.0KCount1.0K0101

102

103

104

105

106

107SSC-H500K1.0M1.5M0101

102

103

104

105

106

107SSC-H500K1.0M1.5M0101

102

103

104

105

106

107SSC-H500K1.0M1.5M0101

102

103

104

105

106

107SSC-H500K1.0M1.5M0應(yīng)用案例展示DC細胞分化GMP-grade

Human

GM-CSF,

IL-4,

and

TNF-alpha(Cat#:

GMP-10015-HNAH;

Cat#:

GMP-11846-HNAE;

Cat#:

GMP-10602-HNAE)Immature

DCsSSC-H500K1.0M1.5M0SSC-H500K1.0M1.5M0SSC-H500K1.0M1.5M0Count2.5K2.0K1.5K1.0K5000101

102

103

104

105

106

107

101

102

103

104

105

106

107

101

102

103

104

105

106

107

101

102

103

104

105

106

107

101

102

103

104

105

106

107Dendritic

Cells

(DCs)

generation

and

maturation

were

detected

by

FACS

analysis.CD14+

monocytes

were

differentiated

into

immature

DCs

by

GM-CSF

(Cat#:

GMP-10015-HNAH)

and

IL-4(Cat#:

GMP-11846-HNAE)

for

6

days.

DCs

were

matured

by

TNF

(Cat#:

GMP-10602-HNAE)

for

2

days.北京義翹神州科技股份有限公司Count1.0K1.5K2.0K5000Mature

DCs北京義翹神州科技股份有限公司免疫細胞培養(yǎng)細胞因子07產(chǎn)品數(shù)據(jù)展示經(jīng)HPLC驗證高活性高純度GMP-grade

Human

IL-4(Cat#:

GMP-11846-HNAE)GMP-grade

Human

TNF-alpha(Cat#:

GMP-10602-HNAE)低內(nèi)毒素高批間一致性Cell

proliferation

assay

using

TF-1

humanerythroleukemic

cellsCytotoxicity

assay

using

L929

mouse

fibrosarcoma

cellsin

the

presence

of

the

metabolic

inhibitor

actinomycin

D-1001E-5

1E-4

1E-3

0.01

0.1

1 10

100Human

IL-4

Conc.

(ng/mL)8007006005004003002001000Proliferation,%Sinobiological

CompetitorR1E-3

0.01

0.11 10

100

1000

10000-20100806040200Cytotoxicity,%Human

TNF-α

Conc.(ng/mL)Sinobiological

CompetitorRDC細胞培養(yǎng)細胞因子推薦HPLC-VerifiedAnimal-FreeGMP-Grade

Available細胞因子貨號種屬表達宿主純度內(nèi)毒素BMP410609-HNAE2HumanE.

coli≥

95%<

1.0

EU/μgFlt3

Ligand/FLT3LG10315-HNAEHumanE.

coli≥

95%<

10

EU/mgGMP-10315-HNAE1-L-AFHumanE.

coli≥

95%<

10

EU/mgGM-CSF/CSF210015-HNAHHumanHEK293

Cells≥

95%<

10

EU/mgGMP-10015-HNAHHumanHEK293

Cells≥

95%<

5

EU/mgIFN

gamma11725-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-11725-HNAEHumanE.

coli≥

95%<

5

EU/mgIL-1

beta10139-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-10139-HNAEHumanE.

coli≥

95%<

5

EU/mgIL-311858-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-11858-HNAEHumanE.

coli≥

95%<

5

EU/mgIL-411846-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-11846-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-11846-HNAE-LHumanE.

coli≥

95%<

10

EU/mgIL-610395-HNAEHumanE.

coli≥

95%<

10

EU/mgGMP-10395-HNAEHumanE.

coli≥

95%<

5

EU/mgIL-1010947-HNAEHumanE.

coli≥

95%<20

EU/mgM-CSF/CSF111792-HNAH1HumanHEK293

Cells≥

95%<

10

EU/mgSCF10451-HNAEHumanE.

coli≥

95%<

10

EU/mgGMP-10451-HNAE1-L-AFHumanE.

coli≥

95%<

10

EU/mgThrombopoietin10381-H07HHumanHEK293

Cells>

90%<

1.0

EU/μgTNF-alpha10602-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-10602-HNAEHumanE.

coli≥

95%<

5

EU/mgVEGF16511066-HNAHHuman,

CynomolgusHEK293

Cells≥

95%<

10

EU/mg北京義翹神州科技股份有限公司08免疫細胞培養(yǎng)細胞因子B細胞可產(chǎn)生抗體介導(dǎo)體液免疫應(yīng)答，在適應(yīng)性免疫應(yīng)答中發(fā)揮重要作用，主要包括中和作用、調(diào)理吞噬作用、參與補體的溶細胞或溶菌作用以及ADCC作用。B細胞作為抗原提呈細胞，能捕獲可溶性抗原，但只有活化的B細胞才能提呈抗原。此外，B細胞可分泌細胞因子參與炎癥反應(yīng)和造血等過程。在B細胞的發(fā)育過程中，有多種細胞因子會影響B(tài)細胞的生長和存活。IL-4和IL-6可影響B(tài)細胞優(yōu)先分泌特定類別的抗體，IL-7主要使發(fā)育中的B細胞存活。義翹神州開發(fā)了一系列高純度、高生物活性、低內(nèi)毒素的高品質(zhì)細胞因子，全面支持B細胞培養(yǎng)及其相關(guān)研究。B細胞培養(yǎng)產(chǎn)品數(shù)據(jù)展示GMP-grade

Human

IL-7

(Cat#:

GMP-11821-HNAE)高純度

高活性

經(jīng)HPLC驗證低內(nèi)毒素高批間一致性5

10

15

20 25

min≥

95%

as

determined

by

SDS-PAGE

andSEC-HPLCCell

proliferation

assay

using

anti-CD3antibody

activated

human

peripheralblood

mononuclear

cellCell

proliferation

assay

using

anti-CD3antibody

activated

human

peripheralblood

mononuclear

cell

(PBMC)kDa

M

11666.245.035.025.018.414.4mAU

7060504030201000.11

10

100Human

IL-7

Conc.

(ng/mL)10009008007006005004003002001000Proliferation,%Batch

1Batch

20.1

1

1010010009008007006005004003002001000Proliferation,%Human

IL-7

Conc.

(ng/mL)Competitor

R

SinobiologicalB細胞培養(yǎng)細胞因子推薦HPLC-VerifiedAnimal-FreeGMP-Grade

Available細胞因子貨號種屬表達宿主純度內(nèi)毒素BAFF/BLyS/TNFSF13B10056-HNCHHumanHEK293

Cells>

95%<

1.0

EU/μgCD40

Ligand/TNFSF510239-H01HHumanHEK293

Cells≥

95%<

1.0

EU/μgFlt3

Ligand/FLT3LG10315-HNAEHumanE.

coli≥

95%<

10

EU/mgGMP-10315-HNAE1-L-AFHumanE.

coli≥

95%<

10

EU/mgIFN

gamma11725-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-11725-HNAEHumanE.

coli≥

95%<

5

EU/mgIL-211848-HNAE2HumanE.

coli>

95%<

5

EU/mgGMP-11848-HNAEHumanE.

coli≥

95%<

5

EU/mgIL-411846-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-11846-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-11846-HNAE-LHumanE.

coli≥

95%<

10

EU/mgIL-711821-HNAEHumanE.

coli≥

95%<

10

EU/mgGMP-11821-HNAEHumanE.

coli≥

95%<

10

EU/mgIL-1010947-HNAEHumanE.

coli≥

95%<20

EU/mgIL-2110584-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-10584-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-10584-HNAE1-L-AFHumanE.

coli≥

95%<

10

EU/mg免疫細胞培養(yǎng)細胞因子09單核/巨噬細胞是機體重要的免疫細胞，具有抗感染、抗腫瘤、呈遞抗原以及免疫調(diào)節(jié)等重要作用，可清除病原體、受損細胞并刺激適應(yīng)性免疫應(yīng)答，與慢性疾病、自身免疫性疾病、纖維化、糖尿病和腫瘤的發(fā)生和進展相關(guān)。GM-CSF、IFN

gamma、IL-4和M-CSF與單核/巨噬細胞體外培養(yǎng)密切相關(guān)，義翹神州已開發(fā)了一系列高品質(zhì)細胞因子，全面支持單核/巨噬細胞培養(yǎng)、疾病治療、新型腫瘤療法開發(fā)等相關(guān)研究。產(chǎn)品數(shù)據(jù)展示GMP-grade

Human

IFN

gamma

(Cat#:

GMP-11725-HNAE)單核/巨噬細胞培養(yǎng)經(jīng)HPLC驗證高活性高純度低內(nèi)毒素高批間一致性單核/巨噬細胞培養(yǎng)細胞因子推薦0.11

10

100HumanIFN-gamma

Conc.

(ng/mL)0.300.250.350.400.450.50OD-BlankEC50=0.06-0.3

ng/mLmAU120100806040200kDa

M

11666.245.035.025.018.414.45

10

15

20 25

min≥

95%

as

determined

by

SDS-PAGE

andSEC-HPLCMeasuredin

anti-viral

assays

using

WISH

cells

infectedwith

vesicular

stomatitisvirus

(VSV)HPLC-Verified Animal-Free北京義翹神州科技股份有限公司GMP-Grade

Available細胞因子貨號種屬表達宿主純度內(nèi)毒素GM-CSF/CSF210015-HNAHHumanHEK293

Cells≥

95%<

10

EU/mgGMP-10015-HNAHHumanHEK293

Cells≥

95%<

5

EU/mgIFN

gamma11725-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-11725-HNAEHumanE.

coli≥

95%<

5

EU/mgIL-311858-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-11858-HNAEHumanE.

coli≥

95%<

5

EU/mgIL-411846-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-11846-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-11846-HNAE-LHumanE.

coli≥

95%<

10

EU/mgIL-610395-HNAEHumanE.

coli≥

95%<

10

EU/mgGMP-10395-HNAEHumanE.

coli≥

95%<

5

EU/mgIL-1010947-HNAEHumanE.

coli≥

95%<20

EU/mgIL-1310369-HNACHumanCHO

StableCells>

92%<

1.0

EU/μgM-CSF/CSF111792-HNAH1HumanHEK293

Cells≥

95%<

10

EU/mgSCF10451-HNAEHumanE.

coli≥

95%<

10

EU/mgGMP-10451-HNAE1-L-AFHumanE.

coli≥

95%<

10

EU/mgThrombopoietin10381-H07HHumanHEK293

Cells>

90%<

1.0

EU/μgIL-1

beta10139-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-10139-HNAEHumanE.

coli≥

95%<

5

EU/mgTGF

beta

110804-HNACHuman,

Rhesus,Cynomolgus,

CanineCHO

StableCells>

95%<

1.0

EU/μg10804-H08HHumanHEK293

Cells>

95%<

1.0

EU/μg北京義翹神州科技股份有限公司10免疫細胞培養(yǎng)細胞因子粒細胞是一類高異質(zhì)性的白細胞，可分為中性粒細胞、嗜酸性粒細胞、嗜堿性粒細胞和肥大細胞。粒細胞被活化后，會釋放免疫刺激分子來抵抗病毒和寄生蟲感染，并分泌細胞因子將其他免疫細胞募集到炎癥部位，共同發(fā)揮免疫調(diào)節(jié)作用；此外，粒細胞在慢性炎癥、哮喘、過敏、自身免疫和癌癥等多種疾病中都發(fā)揮著重要的作用。義翹神州已開發(fā)了一系列高純度、高生物活性、低內(nèi)毒素的高品質(zhì)細胞因子，全面支持粒細胞等相關(guān)免疫研究，另有GMP級細胞因子可供選擇，歡迎選購。粒細胞培養(yǎng)產(chǎn)品數(shù)據(jù)展示GMP-grade

Human

GM-CSF/CSF2

(Cat#:

GMP-10015-HNAH)經(jīng)HPLC驗證高活性高純度低內(nèi)毒素高批間一致性5

10

15

20 25

min≥

95%

as

determined

by

SDS-PAGE

andSEC-HPLCMeasuredin

anti-viral

assays

using

WISH

cells

infectedwith

vesicular

stomatitisvirus

(VSV)粒細胞培養(yǎng)細胞因子推薦HPLC-VerifiedAnimal-FreeGMP-Grade

Available1E-5

1E-4

1E-3

0.01

0.1110

10010000200030004000Proliferation

%HumanGM-CSFConc.

(ng/mL)ED50=0.06-0.3

ng/mLmAU

100020406080kDa

M

11666.245.035.025.018.414.4細胞因子貨號種屬表達宿主純度內(nèi)毒素G-CSF10007-HNAHHumanHEK293

Cells≥

95%<

10

EU/mgGM-CSF/CSF210015-HNAHHumanHEK293

Cells≥

95%<

10

EU/mgGMP-10015-HNAHHumanHEK293

Cells≥

95%<

5

EU/mgIL-311858-HNAEHumanE.

coli≥

95%<

5

EU/mgGMP-11858-HNAEHumanE.

coli≥

95%<

5

EU/mgIL-515673-HNCEHumanE.

coli>

95%IL-610395-HNAEHumanE.

coli≥

95%<

10

EU/mgGMP-10395-HNAEHumanE.

coli≥

95%<

5

EU/mgM-CSF/CSF111792-HNAH1HumanHEK293

Cells≥

95%<

10

EU/mgSCF10451-HNAEHumanE.

coli≥

95%<

10

EU/mgGMP-10451-HNAE1-L-AFHumanE.

coli≥

95%<

10

EU/mgThrombopoietin10381-H07HHumanHEK293

Cells>

90%<

1.0

EU/μgVEGF16511066-HNAHHuman,

CynomolgusHEK293

Cells≥

95%<

10

EU/mg北京義翹神州科技股份有限公司免疫細胞培養(yǎng)細胞因子11義翹神州致力于開發(fā)高質(zhì)量的用于細胞治療研究及臨床的相關(guān)試劑，除RUO級和GMP級細胞因子之外，我們還提供CD3

(OKT3)/CD28激活抗體、CAR-T/CAR-NK細胞檢測流式抗體和細胞因子檢測ELISA試劑盒等高品質(zhì)產(chǎn)品，更好地助力細胞治療藥物開發(fā)和生產(chǎn)。更多免疫細胞培養(yǎng)相關(guān)產(chǎn)品GMP級CD3

(OKT3)單克隆抗體(Cat#:

GMP-10977-H001)GMP級CD28單克隆抗體(Cat#:

GMP-11524-H001)Effect

of

human

CD3

(humanized

OKT3)

antibodyon

the

proliferation

and

IFN-gamma

secretion

ofCD4+

T

cellsGMP級CD3

(OKT3)/CD28激活抗體CAR-T/CAR-NK細胞檢測流式抗體特異性好

親和力佳

信噪比優(yōu)多種標記嚴格按照GMP規(guī)范生產(chǎn)，質(zhì)量標準參照《中國藥典》2020版四部

15項質(zhì)控指標，涵蓋支原體、異常毒性、宿主DNA殘留、HCP殘留等高純度，超低內(nèi)毒素（<0.5

EU/mg），高生物活性高批間一致性，現(xiàn)貨供應(yīng)400200060080010000.1101Anti-CD3(μg/mL)Proliferation,%300250200150100503501E-4