Carprofen-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemECarprofen(Standard)Cat.No.:HY-B1227RCASNo.:53716-49-7分?式:C??H??ClNO?分?量:273.71作?靶點:COX;FAAH;Autophagy;EndogenousMetabolite作?通路:Immunology/Inflammation;MetabolicEnzyme/Protease;NeuronalSignaling;Autophagy儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Carprofen(Standard)Carprofen的分析標(biāo)準(zhǔn)品。本產(chǎn)品?于研究及分析應(yīng)?。Carprofen?種?甾體類抗炎劑，為多靶點FAAH/COX抑制劑，能夠抑制COX-2，COX-1和FAAH的活性，IC50值分別為3.9μM，22.3μM和78.6μM。IC50&TargetIC50:3.9μM(COX-2),22.3μM(COX-1),78.6μM(FAAH)[1]REFERENCES[1].FaviaAD,etal.Identificationandcharacterizationofcarprofenasamultitargetfattyacidamidehydrolase/cyclooxygenaseinhibitor.JMedChem.2012Oct25;55(20):8807-26.[2].WaldherrK,etal.Invitrocytoprotectiveeffectsofacetylsalicylicacid,carprofen,meloxicam,orrobenacoxibagainstapoptosisinducedbysodiumnitroprussideincaninecruciateligamentcells.AmJVetRes.2012Nov;73(11):1752-8.[3].SessionsJK,etal.Invivoeffectsofcarprofen,deracoxib,andetodolaconprostanoidproductioninblood,gastricmucosa,andsynovialfluidindogswithchronicosteoarthritis.AmJVetRes.2005May;66(5):812-7.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:021-