Methylene-blue-purity-70-Basic-Blue-9-purity-70-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEMethyleneblue(purity≥70%)Cat.No.:HY-14536ACASNo.:61-73-4Synonyms:BasicBlue9(purity≥70%);CI-52015(purity≥70%);Methylthioniniumchloride(purity≥70%)分?式:C??H??ClN?S分?量:319.85作?靶點(diǎn):GuanylateCyclase;MonoamineOxidase;NOSynthase;Microtubule/Tubulin作?通路:GPCR/GProtein;NeuronalSignaling;Immunology/Inflammation;CellCycle/DNADamage;Cytoskeleton儲(chǔ)存?式:4°C,storedundernitrogen*Insolvent:-80°C,6months;-20°C,1month(storedunder

nitrogen)BIOLOGICALACTIVITY?物活性Methyleneblue(purity≥70%)?種鳥(niǎo)苷酸環(huán)化酶(sGC)，單胺氧化酶A(MAO-A)和NO合酶(NOS)抑制劑。Methyleneblue(purity≥70%)?種?管加壓劑，在醫(yī)療中通常?作染料。Methyleneblue(purity≥70%)通過(guò)?氧化氮合成酶/鳥(niǎo)苷酸環(huán)化酶信號(hào)通路降低脈沖前抑制。Methyleneblue(purity≥70%)blue(purity≥70%)Tau聚集抑制劑。亞甲藍(lán)可減輕腦?腫，減弱?膠質(zhì)細(xì)胞活化，減少神經(jīng)炎癥。REFERENCES[1].KlamerD,et,al.Phencyclidine-inducedbehaviourinmicepreventedbymethyleneblue.BasicClinPharmacolToxicol.2004Feb;94(2):65-72.[2].Hochgr?feK,et,al.Preventivemethylenebluetreatmentpreservescognitioninmiceexpressingfull-lengthpro-aggreganthumanTau.ActaNeuropatholCommun.2015May10;3:25.[3].FennAM,et,al.Methyleneblueattenuatestraumaticbraininjury-associatedneuroinflammationandacutedepressive-likebehaviorinmice.JNeurotrauma.2015Jan15;32(2):127-38.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:02