Osthole-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEOsthole(Standard)Cat.No.:HY-N0054RCASNo.:484-12-8分?式:C??H??O?分?量:244.29作?靶點(diǎn):HistamineReceptor;Apoptosis;Parasite;HBV作?通路:GPCR/GProtein;Immunology/Inflammation;NeuronalSignaling;Apoptosis;Anti-infection儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性O(shè)sthole(Standard)Osthole的分析標(biāo)準(zhǔn)品。本產(chǎn)品?于研究及分析應(yīng)?。Osthole(Osthol)?種天然抗組胺藥替代試劑。Osthole可有效抑制組胺H1受體(histamineH1receptor)活性。Osthole還可抑制細(xì)胞培養(yǎng)物中HBV的分泌。IC50&TargetHistamineH1receptor[1]REFERENCES[1].KordulewskaNK,etal.Changesingeneexpressioninducedbyhistamine,fexofenadineandosthole:ExpressionofhistamineH1receptor,COX-2,NF-κB,CCR1,chemokineCCL5/RANTESandinterleukin-1βinPBMCallergicandnon-allergicpatients.Immunobiology.[2].TangDZ,etal.Ostholestimulatesosteoblastdifferentiationandboneformationbyactivationofbeta-catenin-BMPsignaling.JBoneMinerRes.2010Jun;25(6):1234-45.[3].SunW,etal.OstholepretreatmentalleviatesTNBS-inducedcolitisinmiceviabothcAMP/PKA-dependentandindependentpathways.ActaPharmacolSin.2017Aug;38(8):1120-1128.[4].ZhangZR,etal.Osthole:AReviewonItsBioactivities,PharmacologicalProperties,andPotentialasAlternativeMedicine.EvidBasedComplementAlternatMed.2015;2015:919616.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax