Promethazine-racemic-Promethazine-生命科學試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEPromethazineCat.No.:HY-B1296CASNo.:60-87-7Synonyms:(±)-Promethazine分?式:C??H??N?S分?量:284.42作?靶點:HistamineReceptor作?通路:GPCR/GProtein;Immunology/Inflammation;NeuronalSignaling儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Promethazine?種抗組胺化合物，H1受體強效拮抗劑，吩噻嗪家族的第?代抗組胺化合物，該化合物可?于精神類疾病研究。體外研究Promethazine(0-100μM,24h)inhibitstheproliferationofSW480,HCT116,HT29andCaco2CRCcellsinaconcentration-dependentmanner[5].CellViabilityAssay[5]CellLine:SW480,HCT116,HT29,andCaco2CRCcellsConcentration:0-100μMIncubationTime:24hoursResult:ExhibitedIC50valuesof40.96,74.79,27.34and33.00μMinCaco2,HCT116,HT29andSW480cells,respectively.體內(nèi)研究Promethazine(intraperitonealinjection;2mg/kg,4mg/kg,6mg/kg;once)iseffectiveinreducingthewrithingresponse[6].AnimalModel:MaleNMRImice(20-30g)injectedwithaceticacid(0.7%)[6]1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEDosage:2mg/kg,4mg/kg,6mg/kgAdministration:Intraperitonealinjection;2mg/kg,4mg/kg,6mg/kg;onceResult:Inhibitedwrithingresponseby43.2%,53.9%and62.3%at2,4,6mg/kg.?PLoSNeglTropDis.2019Aug20;13(8):e0007681.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].BurtDR,etal.Antischizophrenicdrugs:chronictreatmentelevatesdopaminereceptorbindinginbrain.Science.1977Apr15;196(4287):326-8.[2].Strenkoski-NixLC,etal.Pharmacokineticsofpromethazinehydrochlorideafteradministrationofrectalsuppositoriesandoralsyruptohealthysubjects.AmJHealthSystPharm.2000Aug15;57(16):1499-505.[3].FiorellaD,etal.Theroleofthe5-HT2Aand5-HT2Creceptorsinthestimuluseffectsofhallucinogenicdrugs.I:Antagonistcorrelationanalysis.Psychopharmacology(Berl).1995Oct;121(3):347-56.[4].SeemanP,etal.DopamineD2receptorbindingsitesforagonists.Atetrahedralmodel.MolPharmacol.1985Nov;28(5):391-9.[5].XinyueTan,etal.PromethazineinhibitsproliferationandpromotesapoptosisincolorectalcancercellsbysuppressingthePI3K/AKTpathway.BiomedPharmacother.2021Nov;143:112174.[6].NiloofarAmidi,etal.ABehavioralStudyofPromethazineInteractionwithAnalgesicEffectofDiclofenac:PainCombinationTherapy.JPharmacopuncture.2020Mar31;23(1):18-24.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forre