S-10-Hydroxycamptothecin-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemE(S)-10-Hydroxycamptothecin(Standard)Cat.No.:HY-N0095RCASNo.:19685-09-7分?式:C??H??N?O?分?量:364.35作?靶點(diǎn):Topoisomerase;Apoptosis作?通路:CellCycle/DNADamage;Apoptosis儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性(S)-10-Hydroxycamptothecin(Standard)(S)-10-Hydroxycamptothecin的分析標(biāo)準(zhǔn)品。本產(chǎn)品?于研究及分析應(yīng)?。(S)-10-Hydroxycamptothecin(10-HCPT;10-Hydroxycamptothecin)?種從喜樹中分離的DNA拓?fù)洚悩?gòu)酶I(DNAtopoisomeraseI)抑制劑。(S)-10-Hydroxycamptothecin可顯誘導(dǎo)細(xì)胞凋亡，并可?于肝癌，胃癌，結(jié)腸癌和??病的研究。REFERENCES[1].MinLiu,etal.Intracellulardeliveryof10-hydroxycamptothecinwithtargetednanostructuredlipidcarriersagainstmultidrugresistance.JournalofDrugTargeting.[2].MinLiu,etal.Intracellulardeliveryof10-hydroxycamptothecinwithtargetednanostructuredlipidcarriersagainstmultidrugresistance.JDrugTarget,EarlyOnline:1–8[3].YuP,etal.Synthesisandpreliminaryanticancerevaluationof10-hydroxycamptothecinanalogs.BiolPharmBull.2012;35(8):1295-9.[4].ZhangXW,etal.Differentiation-inducingactionof10-hydroxycamptothecinonhumanhepatomaHepG2cells.ActaPharmacolSin.2000Apr;21(4):364-8.[5].ZhangXW,etal.DifferentialregulationofP53,c-Myc,Bcl-2,BaxandAFPproteinexpression,andcaspaseactivityduring10-hydroxycamptothecin-inducedapoptosisinHepG2cells.AnticancerDrugs.2000Oct;11(9):747-56.[6].LiuM,etal.Intracellulardeliveryof10-hydroxycamptothecinwithtargetednanostructuredlipidcarriersagainstmultidrugresistance.JDrugTarget.2016;24(5):433-40.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-