Celiprolol-hydrochloride-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemECeliprolol(hydrochloride)(Standard)Cat.No.:HY-B1264RCASNo.:57470-78-7分子式:C??H??ClN?O?分子量:415.95作用靶點:NOSynthase;AdrenergicReceptor作用通路:Immunology/Inflammation;GPCR/GProtein;NeuronalSignaling儲存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性 Celiprolol(hydrochloride)(Standard)是Celiprolol(hydrochloride)的分析標(biāo)準(zhǔn)品。本產(chǎn)品用于研究及分析應(yīng)用。Celiprolol(REV5320)是一種有效的，具有口服活性的心臟選擇性的β1-雄激素受體(β1-andrenoceptor)拮抗劑，具有部分β2激動劑活性，其Ki值為0.14-8.3μM。Celiprolol具有降壓和抗心絞痛的活性，可被用于高血壓等心血管疾REFERENCESJamesJNawarskas,et,al.Celiprolol:AUniqueSelectiveAdrenoceptorModulator.CardiolRev.Sep/Oct2017;25(5):247-253.ToshioHayashi,etal.beta1antagonistandbeta2agonist,celiprolol,restorestheimpairedendothelialdependentandindependentresponsesanddecreasedTNFalphainratwithtypeIIdiabetes.LifeSci.2007Jan16;80(6):592-9.NaohikoKobayashi,etal.CeliprololactivateseNOSthroughthePI3K-AktpathwayandinhibitsVCAM-1ViaNF-kappaBinducedbyoxidativestress.Hypertension.2003Nov;42(5):1004-13.RGVanInwegen,etal.Effectsofceliprolol(REV5320),anewcardioselectivebeta-adrenoceptorantagonist,oninvitroadenylatecyclase,alpha-andbeta-adrenergicreceptorbindingandlipolysis.ArchIntPharmacodynTher.1984Nov;272(1):40-55.YukioKato,etal.Involvementofinfluxandeffluxtransportsystemsingastrointestinalabsorptionofceliprolol.JPharmSci.2009Jul;98(7):2529-39.J.Karlsson,etal.Transportofceliprololacrosshumanintestinalepithelial(Caco-2)cells:mediationofsecretionbymultipletransportersincludingP-glycoprotein.BrJPharmacol.1993Nov;110(3):1009–1016.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-379