ChCD分子和粘附分子ppt課件

1、All rights reserved by Dr Baiqing LIBengbu Medical College Department of ImmunologyPPT課件課件醫(yī)學(xué)免疫學(xué)醫(yī)學(xué)免疫學(xué)Medical ImmunologyAll rights reserved by Dr Baiqing LIBengbu Medical College Department of Immunology人與人如何人與人如何交流交流? ?All rights reserved by Dr Baiqing LIBengbu Medical College Department of Immunolog

2、y細(xì)胞與細(xì)胞呢細(xì)胞與細(xì)胞呢? ?All rights reserved by Dr Baiqing LIBengbu Medical College Department of Immunology基基 礎(chǔ)礎(chǔ) 免免 疫疫 學(xué)學(xué)Basic Immunology)Basic Immunology)第七章第七章 CD分子和粘附分子分子和粘附分子cluster of differentiation molecules and adhesion moleculesAll rights reserved by Dr Baiqing LIBengbu Medical College Department o

3、f Immunology 免疫細(xì)胞的膜外表分子：免疫細(xì)胞外表存在免疫細(xì)胞的膜外表分子：免疫細(xì)胞外表存在著大量不同種類的蛋白質(zhì)分子，如受體、配著大量不同種類的蛋白質(zhì)分子，如受體、配體、體、MHC分子、信號(hào)傳導(dǎo)分子等。分子、信號(hào)傳導(dǎo)分子等。 CD分子和粘附分子均為免疫細(xì)胞的膜外分子和粘附分子均為免疫細(xì)胞的膜外表分子。表分子。All rights reserved by Dr Baiqing LIBengbu Medical College Department of Immunology(一一) CD分子：分子：白細(xì)胞分化抗原白細(xì)胞分化抗原(leukocyte differentiation an

4、tigen) 血細(xì)胞在發(fā)育、分化不同階段或活化血細(xì)胞在發(fā)育、分化不同階段或活化過程中表達(dá)的膜外表分子過程中表達(dá)的膜外表分子,多為跨膜蛋白多為跨膜蛋白或糖蛋白?；蛱堑鞍?。 CD(Cluster of differentiation) ：利用不：利用不同分化抗原的抗原性可制備相應(yīng)的單克同分化抗原的抗原性可制備相應(yīng)的單克隆抗體，以隆抗體，以CD表示。表示。 2019年公布的人的年公布的人的CD編號(hào)已從編號(hào)已從CD1CD247附錄。附錄。All rights reserved by Dr Baiqing LIBengbu Medical College Department of Immunology

5、 參與細(xì)胞間粘附和跨膜信號(hào)傳送，如參與細(xì)胞間粘附和跨膜信號(hào)傳送，如 CD3、CD4、CD28等。等。Th B7 CD4 ICAM LFA-1APC CD28CD28CD分子的主要作用：分子的主要作用：All rights reserved by Dr Baiqing LIBengbu Medical College Department of Immunology 用于細(xì)胞的鑒定：如T細(xì)胞標(biāo)志：CD3+；B細(xì)胞標(biāo)志：CD19+ CD21+ ；NK細(xì)胞標(biāo)志：CD16+CD56+；。All rights reserved by Dr Baiqing LIBengbu Medical College

6、 Department of Immunology(二二) 細(xì)胞粘附分子細(xì)胞粘附分子 cell adhesion molecule，CAM -介導(dǎo)細(xì)胞與細(xì)胞或細(xì)胞與細(xì)胞外基質(zhì)間相互接觸和結(jié)合的蛋白質(zhì)。 據(jù)構(gòu)造劃分為四類據(jù)構(gòu)造劃分為四類: All rights reserved by Dr Baiqing LIBengbu Medical College Department of Immunology1. 免疫球蛋白超家族免疫球蛋白超家族IgSF -含有一個(gè)或多個(gè)與含有一個(gè)或多個(gè)與Ig構(gòu)造類似的黏附構(gòu)造類似的黏附分子。如分子。如: CD3, CD4, CD8All rights reserve

7、d by Dr Baiqing LIBengbu Medical College Department of Immunology2. 整合素家族：整合素家族：integrin -由、鏈組成的異二聚體分子。 如：LFA-1CD11a/CD18、CR3等。All rights reserved by Dr Baiqing LIBengbu Medical College Department of Immunology3 3 選擇素家族選擇素家族selectinselectin - -是一類細(xì)胞膜外表單肽分子，是一類細(xì)胞膜外表單肽分子，介導(dǎo)白細(xì)胞與內(nèi)皮細(xì)胞粘附、參與炎癥介導(dǎo)白細(xì)胞與內(nèi)皮細(xì)胞粘附、

8、參與炎癥發(fā)生及淋巴細(xì)胞歸巢。發(fā)生及淋巴細(xì)胞歸巢。 包括包括: L-: L-選擇素白細(xì)胞選擇素，選擇素白細(xì)胞選擇素， E- E-選擇素內(nèi)皮細(xì)胞選選擇素內(nèi)皮細(xì)胞選擇素，擇素， P- P-選擇素血小板選擇選擇素血小板選擇素。素。All rights reserved by Dr Baiqing LIBengbu Medical College Department of ImmunologyAll rights reserved by Dr Baiqing LIBengbu Medical College Department of Immunology4 4 鈣粘素家族：鈣粘素家族：cadheri

9、ncadherin 一組需求鈣離子參與，主要介導(dǎo)同型細(xì)胞間相一組需求鈣離子參與，主要介導(dǎo)同型細(xì)胞間相互粘附的分子互粘附的分子, 如如: E-鈣粘素內(nèi)皮鈣粘素；鈣粘素內(nèi)皮鈣粘素； N-鈣粘素神經(jīng)鈣粘素；鈣粘素神經(jīng)鈣粘素； P-鈣粘素胎盤鈣粘素。鈣粘素胎盤鈣粘素。All rights reserved by Dr Baiqing LIBengbu Medical College Department of ImmunologyAll rights reserved by Dr Baiqing LIBengbu Medical College Department of Immunology粘附分子的生物學(xué)功能粘附分子的生物學(xué)功能 參與免疫細(xì)胞的分化和發(fā)育參與免疫細(xì)胞的分化和發(fā)育 參與免疫應(yīng)對(duì)參與免疫應(yīng)對(duì)( (提供輔助受體和協(xié)同提供輔助受體和協(xié)同刺激信號(hào)等刺激信號(hào)等) ) 參與炎癥反響參與炎癥反響 參與淋巴細(xì)胞的歸巢和再循環(huán)參與淋巴細(xì)胞的歸巢和再循環(huán)All rights reserved by Dr Baiqing LIBengbu Medical College Department of ImmunologyAll rights reserved by Dr Baiqing LIBengbu Medical College Department of Immunology