松齡血脈康膠囊對原發(fā)性高血壓患者動態(tài)血壓相關(guān)指標的影響：隨機 醫(yī)學論文

1、    松齡血脈康膠囊對原發(fā)性高血壓患者動態(tài)血壓相關(guān)指標的影響：隨機 醫(yī)學論文              本文由中國論文范文收集整理。                         作者：付莉, 毛振興, 王

2、靜, 張靜, 鄭太蓉, 王勝蓮 【摘要】   在聯(lián)合使用鈣離子拮抗劑及血管緊張素受體拮抗劑的基礎(chǔ)上加用中成藥，觀察其對24 h動態(tài)血壓監(jiān)測相關(guān)指標的影響，評價降壓效應(yīng)及降壓穩(wěn)定性。方法：將70例初診為原發(fā)性高血壓或有原發(fā)性高血壓病史但服藥無 規(guī)律 或未正規(guī)服藥，就診時血壓分級為23級的患者隨機分為常規(guī)降壓組（常規(guī)組）和常規(guī)降壓加松齡血脈康組（松齡血脈康組），每組各35例。常規(guī)組口服左旋氨氯地平片2.5 mg，聯(lián)合替米沙坦片40 mg，1次/d。松齡血脈康組在常規(guī)組 治療 的基礎(chǔ)上加服松齡血脈康膠囊1.5 g，3次/d。療程均為2周。治療前后分別進行24 h動態(tài)血壓監(jiān)測，并進

3、行谷峰比值、平滑指數(shù)等指標的 計算 和血壓晨峰的判定。結(jié)果：兩組治療后24 h、白晝及夜間平均收縮壓和收縮壓負荷值均低于治療前（P0.05），常規(guī)降壓加松齡血脈康的降壓效果優(yōu)于常規(guī)降壓（P0.05）。常規(guī)降壓加松齡血脈康能降低舒張壓，而常規(guī)降壓對舒張壓的影響不明顯。常規(guī)降壓加松齡血脈康降壓的同時能減慢心率，常規(guī)降壓則對心率影響不明顯。松齡血脈康組谷峰比值高于常規(guī)降壓組（P0.05），兩組平滑指數(shù)比較，差異無統(tǒng)計學意義。兩組治療后血壓晨峰現(xiàn)象均得到改善（P0.05），常規(guī)降壓加松齡血脈康對血壓晨峰現(xiàn)象的改善程度優(yōu)于常規(guī)降壓（P0.05）。結(jié)論：在聯(lián)合使用左旋氨氯地平片和替米沙坦片的基礎(chǔ)上加用中成

4、藥松齡血脈康膠囊，能更有效地降低心率和血壓，特別是收縮壓和收縮壓負荷值，降壓效應(yīng)的平穩(wěn)性更高，維持時間更長，還能有效控制血壓晨峰現(xiàn)象。 【關(guān)鍵詞】   高血壓; 血壓測定; 隨機對照試驗; 單盲法    Objective: To explore the effects of Western medicine including Ca2+ channel antagonist and angiotensin?receptor antagonist combined with Songling Xuemaikang Capsule (SXC), a com

5、pound traditional Chinese herbal medicine for calming liver and suppressing liver yang, on blood pressure indexes derived from 24?hour ambulatory blood pressure monitoring (ABPM), and to evaluate the effects and stability of SXC in lowering blood pressure.    Methods: Seventy patients

6、 with essential hypertension of grade 2 or grade 3 were randomly assigned to routine group and SXC group. There were 35 cases in each group. The patients in the routine group were administered with 2.5 mg levoamlodipine and 40 mg telmisartan once daily, and 1.5 g SXC was administered orally to the p

7、atients in the SXC group three times daily besides levoamlodipine and telmisartan treatment. They were all treated for two weeks. Twenty?four?hour ABPM, trough to peak ratio and smoothness index were measured before and after the treatment.    Results: Twenty?four?hour, day and night

8、average systolic blood pressure (SBP) and 24?hour, day and night SBP load in the two groups were lowered as compared with before treatment (P0.05). The effects of Western medicine combined with SXC on blood pressure depression were better than those of Western medicine (P0.05). Western medicine comb

9、ined with SXC had a significant influence on diastolic blood pressure (DBP) as compared with Western medicine (P0.05). The heart rate in the SXC group was reduced as compared with before treatment and the routine group (P0.05). Trough to peak ratio in SXC group was higher than that in the routine gr

10、oup, while there was no significant difference in smoothness index between the two groups. Morning surge in blood pressure in the two groups was improved as compared with before treatment (P0.05), and there was a significant difference in morning surge in blood pressure between the two groups (P0.05

11、).    Conclusion: Western medicine combined with SXC has long?lasting effects in lowering heart rate and blood pressure, especially for SBP and SBP load. SXC plus Western medicine also has an inhibition effect on morning surge in blood pressure.    Keywords: hypertensio

12、n; blood pressure determination; randomized controlled trial; single?blind method    隨著醫(yī)學界對高血壓病防治的研究日益深入，提高降壓治療的質(zhì)量和內(nèi)涵越來越受到重視。平穩(wěn)降壓以及降壓的同時發(fā)揮靶器官保護作用都成為降壓治療時應(yīng)考慮的問題。24 h動態(tài)血壓監(jiān)測（ambulatory blood pressure monitoring, ABPM）能提供豐富的血壓數(shù)據(jù)，全面準確地反映患者血壓的波動、節(jié)律和變異性，從而優(yōu)化個體化降壓策略，評估降壓效果和質(zhì)量。本研究運用24 h動態(tài)血壓監(jiān)測方法，評價中成藥松齡血脈康膠囊（Songling Xuemaikang Capsule, SXC）對動態(tài)血壓相關(guān)數(shù)據(jù)的影響。 關(guān)鍵詞:相關(guān),指標,影響,隨機,動態(tài),患者,醫(yī)