膿毒癥論文：膿毒癥心功能甘草酸二銨盲腸結(jié)扎穿孔

1、【英文關(guān)鍵詞】SepsisCardiacfunctionDiammoniumGlycyrrhizinateCecalligationpuncture膿毒癥論文：甘草酸二銨對(duì)膿毒癥大鼠心功能保護(hù)作用的研究【中文摘要】觀察不同劑量甘草酸二銨對(duì)膿毒癥大鼠心功能的保護(hù)作用。方法采用盲腸結(jié)扎穿孔(CLP)法制作大鼠膿毒癥模型，隨機(jī)分為CLP24h48h及72h三個(gè)亞組,并設(shè)立正常對(duì)照(N)組和假手術(shù)(S)組,于不同劑量甘草酸二銨(DG)干預(yù)性治療前后，通過(guò)超聲心動(dòng)技術(shù)檢測(cè)各實(shí)驗(yàn)組大鼠心功能相關(guān)指標(biāo)：左室舒張末期內(nèi)徑與左室收縮末期內(nèi)徑(LVIDd.LVIDs),射血分?jǐn)?shù)(EF)、左室短軸縮短率(FS)、心

2、率(HR)、心輸出量(CO)的變化。結(jié)果膿毒癥(CLP)組大鼠心功能指標(biāo)，相對(duì)于正常對(duì)照組和假手術(shù)組，差異具有統(tǒng)計(jì)學(xué)意義(PvO.05)；DG小劑量組與膿毒癥(CLP)組比較：大鼠的左室舒張末期內(nèi)徑與左室收縮末齊內(nèi)徑減小，差異具有統(tǒng)計(jì)學(xué)意義(PvO.05);而射血分?jǐn)?shù)、左室短軸縮短率、心率、心輸出量?jī)山M比較無(wú)明顯變化。DG中劑量組及大劑量組與膿毒癥(CLP)組比較,各項(xiàng)指標(biāo)比較差異均具有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論一定劑量甘草酸二銨可減輕膿毒癥大鼠心肌損傷，對(duì)膿毒癥大鼠心功能具有保護(hù)作用。購(gòu)買(mǎi)全文在線加QQ139938848即付即發(fā)同時(shí)提供論文寫(xiě)作指導(dǎo)和學(xué)術(shù)期刊發(fā)表服務(wù)在:本立為學(xué)術(shù)

3、立獻(xiàn)總庫(kù)合作提供I如有異溟請(qǐng)與總庫(kù)或?qū)W校聯(lián)系"0【英文摘要】Observedifferentdosediammoniumglycyrrhizinatetosepsisratscardiacfunctionofprotection.MethodsWistarratsweresubjectedtoanoperationofcercalligationpuncture.Theywererandomlydividedinto24hour,48hourand72hourgroups,andanormalgroup,ashamgroup,with5ratsineachgroup.Inadiffe

4、rentdosediammoniumglycyrrhizinate(DG)interveningbeforeandaftertreatment,throughtheultrasoniccardiogramtorecordthecardiacfunctiontestingindexofsepsisrats:leftventricularend-diastolicdiameterandinnerdiameterattheendofthecontract(LVIDd,LVIDs),ejectionfraction(EF),leftventricularshortshaftshortened(FS),

5、heartrate(HR),cardiacoutput(CO).Resultssepsisrats,cardiacindexrelativetothenormalcontrolgroupandshamgroup,astatisticallysignificantdifferenee(P<0.05);DGsmalldosegroupofgroupcomparedwithCLP:theratleftventricularend-diastolicdiameterandshrinkageinnerdiameterattheendofthereduced,astatisticallysignif

6、icantdifferenee(P<0.05);Andleftventricularejectionfraction,shortshaftshortenedrate,heartrate,andcardiacoutput,twogroupsofcomparisonsnochange.ModeratedoseandlargedoseofDGgroupcomparedwiththeCLPgroup,eachindexcomparativedifferencesaresignificant(P<0.05).ConclusionItwasconcludedthatregulardosesdi

7、ammoniumglycyrrhizinatecanreducethemyocardialinjuryoftheratswithsepsisprotectivethecardiacfunction.【目錄】甘草酸二銨對(duì)膿毒癥大鼠心功能保護(hù)作用的研究中文摘要3-4Abstract4第一章前言6-9第二章材料與方法9-152.1實(shí)驗(yàn)材料92.2實(shí)驗(yàn)方法及過(guò)程9-15第三章結(jié)果15-213.1各實(shí)驗(yàn)組大鼠一般情況觀察及模型死亡率評(píng)估153.2各實(shí)驗(yàn)組大鼠心功能指標(biāo)的比較15-21第四章討論21-254.1膿毒癥214.2大鼠膿毒癥模型21-224.3膿毒癥心肌抑制心功能障礙22-234.4膿毒癥心功能障礙與HMGB1234.5膿毒癥與甘草酸二銨23-25結(jié)論25-26主要結(jié)論25需要繼續(xù)探討的問(wèn)題25-26參考文獻(xiàn)26-29綜述29-35