catosal科特壯犬貓疾病支持治療藥物

1、科特壯科特壯犬貓疾病支持治療藥物犬貓疾病支持治療藥物劉久占劉久占德國(guó)拜耳德國(guó)拜耳The Power of Pink支持治療支持治療支持治療是指與特異性療法配合的附加治療支持治療是指與特異性療法配合的附加治療,它可以縮短犬貓疾病的康復(fù)時(shí)間！它可以縮短犬貓疾病的康復(fù)時(shí)間！支持治療支持治療支持治療是指與特異性療法配合的附加治療支持治療是指與特異性療法配合的附加治療,它可以縮短犬貓疾病的康復(fù)時(shí)間！它可以縮短犬貓疾病的康復(fù)時(shí)間！支持治療對(duì)犬貓的重要性支持治療對(duì)犬貓的重要性 一般來(lái)說(shuō)，疾病會(huì)降低犬貓新陳代謝機(jī)能，而新陳代謝機(jī)能降低又會(huì)延緩犬貓的康復(fù)。臨床上特異性治療不會(huì)恢復(fù)患病犬

2、貓的新陳代謝機(jī)能。所以促進(jìn)新陳代謝的支持治療性藥物會(huì)明顯促進(jìn)患病寵物的康復(fù)。患病犬貓需要額外患病犬貓需要額外的能量來(lái)幫助疾病的能量來(lái)幫助疾病康復(fù)康復(fù)總結(jié)總結(jié)簡(jiǎn)而言之:患病動(dòng)物需要更多的能量:a)正常的身體功能需要 b)從疾病中快速康復(fù)支持治療形式支持治療形式 平衡營(yíng)養(yǎng) 充足休息 注意管理 增加多種維生素和礦物質(zhì) 保護(hù)肝臟等ATP+H2OADP+HPO4ENERGY脂類和糖類最終利用的形式 (ATP)ATP 變成ADP并釋放細(xì)胞利用的能量(如:提供給肌肉細(xì)胞)能量的利用方式能量的利用方式能量能量重要的因素重要的因素整個(gè)新陳代謝過(guò)程關(guān)鍵因素是磷元素的代謝磷元素在AMP-ADP-ATP循環(huán)后,有部分

3、會(huì)流失掉理論上,磷元素加入到ADP分子中是提供能量?jī)?chǔ)備的最好方式能量能量 理想的支持治療理想的支持治療磷會(huì)流失磷會(huì)流失,需要不斷補(bǔ)充需要不斷補(bǔ)充提供含能量?jī)?chǔ)備的磷能幫助細(xì)胞更好的工作!隨著能量需求的增加隨著能量需求的增加,富含能量的富含能量的磷混合物可以滿足新陳代謝的需求磷混合物可以滿足新陳代謝的需求CATOSAL就是答案就是答案每 ml含量:布他磷 100.00 mgVit B12 0.05 mgMethyl paraben 1.00 mgPhosphorus content: 17.3 mg/ml提供磷元素提供磷元素提供維生素提供維生素其他其他作用成分作用成分磷含量磷含量: 17.3 mg

4、/mlCatosal 疾病支持治療的關(guān)鍵疾病支持治療的關(guān)鍵科特壯的成分科特壯的成分布他磷布他磷 有機(jī)磷酸有機(jī)磷酸無(wú)味的白色晶體無(wú)味的白色晶體VB12 ButaphosphaneVitamin B12+The Power of Pink科特壯的成分科特壯的成分布他磷布他磷 無(wú)味的白色晶體無(wú)味的白色晶體作用機(jī)理作用機(jī)理通過(guò)促進(jìn)通過(guò)促進(jìn)ADP-ATP循環(huán)，促進(jìn)機(jī)體能量循環(huán)，促進(jìn)機(jī)體能量 代謝。代謝。 促進(jìn)機(jī)體的合成代謝過(guò)程。促進(jìn)機(jī)體的合成代謝過(guò)程。 激活犬貓機(jī)體非特異性免疫反應(yīng)激活犬貓機(jī)體非特異性免疫反應(yīng) 恢復(fù)疲勞肌肉功能?；謴?fù)疲勞肌肉功能。 緩解應(yīng)激緩解應(yīng)激 / 降低激素水平降低激素水平 De G

5、root J., van Der Werf J., van Reenen C., Schuurman T., Schmidt B. (2003) :The effect of butafosfan (component of Catosal) on psychosocial stress in pigs. J. Vet. Pharmacol. Therap. 26 (Suppl. 1), 222-223.Van der Staay J., De Groot J., Schmidt B., Schuurman T. (2006) :Effects of Catosal on the physio

6、logical and behavioral response to social stress in piglets. Proceedings of the 19th IPVS Congress, Copenhagen, Denmark, Volume 2.Simon F (1990) :Study on stress reducing effect of butafosfan in sheep. Institut fr Pharmakologie und Toxikologie, Veterinrmedizinische Universitt, Budapest, Hungary. Bay

7、er ID 12765.Hnsel A., Fuhrmann H., Sallmann H.-P, Klee W. (1992) :Infusion von Propionate and Butyrat als Belastungstest zur berprfung mglicher Butafosfanwirkungen auf den Energiestoffwechsel des Rindes. Berl. Mnch. Tierrztl. Wschr. 105, 361-366.Hasi Su-rong, DU Xiao-yan, ZHU Bei-lei, JIANG Jin-shu

8、(2004a): Studies on Effects of Compound Butaphosphan Solution on Endurance Capability and Energy Metabolism in Mice. Acta Veterinaria Et Zootechnica Sinica, 35 (03 ), 290-294.降低冷熱刺激降低冷熱刺激Stress Reduction / control of cortisol increase.Hasi Su-rong et al. (2004a)*:p0.05, *p:0.001 compared to control

9、group*: p0.05 compared to high dose butaphosphan*%High dose butaphosphan (n=15) : 250 mg/kg butaphosphan once aday for 7 days orally.Low dose butaphosphan (n=15) 125 mg/kg butaphosphan once aday for 7 days orally.Control group (n=15): 10 ml/kg physiologic saline once a dayfor 7 days oral.One hour af

10、ter treatment on the last day, each mouse was placedIn a 300 ml wide-mouthed flask which was sealed with a double layer ofgauze. In order to evaluate the cold tolerance, this was placed in a metabolic cage at 50.5 C with a cyclic pump. But, for the evaluation ofheat tolerance the temperature was 450

11、.5 C.In the cold tolerance study, after 10 hours the number of mice still alivewas recorded. In the heat tolerance study, after 50 minutes, the numberof mice still alive was recorded.布他磷作用于組織缺氧布他磷作用于組織缺氧Hasi Su-rong et al. (2004a)*p:0.05, *p:0.001 compared to control group*存活時(shí)間 (分鐘)High dose butapho

12、sphan (n=12) : 250 mg/kg butaphosphan once aday for 7 days orally.Low dose butaphosphan (n=12) 125 mg/kg butaphosphan once aday for 7 days orally.Control group (n=12): 10 ml/kg physiologic saline once a dayfor 7 days oral.One hour after treatment on the last day, each mouse was placedIn a 300 ml wid

13、e-mouthed flask which was sealed with transparent glad wrapThat did not admit air and timing was commenced. With the termination ofbreathing as the endpoint, the time for each mouse to expire from lack of oxygen was noted, so as to determine the effect of butaphosphanon the tolerance of mice hypoxia

14、.刺激能量產(chǎn)生刺激能量產(chǎn)生參考資料參考資料:Hasi Su-rong, DU Xiao-yan, ZHU Bei-lei, JIANG Jin-shu (2004a): Studies on Effects of Compound Butaphosphan Solution on Endurance Capability and Energy Metabolism in Mice. Acta Veterinaria Et Zootechnica Sinica, 35 (03 ), 290-294.HASI Su-rong , JIANG Jin-shu, DU Xiao-yan, ZHU Be

15、i-lei (2005a): Anti-cold stress effects and mechanisms of compound butaphosphan solution. Progress in Veterinary Medicine, 26, (03), 59-62.HASI Su-rong , JIANG Jin-shu , ZHU Bei-lei , DU Xiao-yan (2005b) : Studies on Anti-Heat Stress Effects and Mechanisms of Compound Butafosfan Solution. Acta Veter

16、inaria Et Zootechnica Sinica, 36 (12), 1334-1338.布他磷刺激肝糖元產(chǎn)生布他磷刺激肝糖元產(chǎn)生Content of liver gycogen (mg/g)* = p0.05, * = p0.001Compared to control groupHasi Su-rong et al. (2004a)Experiment 1(n=12): 250 mg/kg butaphosphan once a day for 7 days orally.Experiment 2 (n=12): 125 mg/kg butaphosphan once a day

17、for 7 days orally.Control group (n=12) : 10 ml/kg physiologic saline solution.One hour after last treatment on thelast day, mice were sacrificed andliver glycogen content was determinedvia spectrometer布他磷刺激肌糖元產(chǎn)生布他磷刺激肌糖元產(chǎn)生Content of muscle glycogen (mg/g)* = p0.01, * = p0.001Compared to control group

18、Hasi Su-rong et al. (2004a)Experiment 1(n=12): 250 mg/kg butaphosphan once a day for 7 days orally.Experiment 2 (n=12): 125 mg/kg butaphosphan once a day for 7 days orally.Control group (n=12) : 10 ml/kg physiologic saline solution.One hour after last treatment on thelast day, mice were sacrificed a

19、ndmuscle glycogen content was determinedvia spectrometer提高提高 肌肉中的肌肉中的Tri-phosphate (ATP) 含量含量Content of muscle ATP (mg/g)* = p0.001Compared to control groupHasi Su-rong et al. (2004a)Butaphosphan treatment group (n=12): 250 mg/kg butaphosphan once a day for 7 days orally.Control group (n=12) : 10 ml

20、/kg physiologic saline solution.One hour after last treatment on thelast day, mice were sacrificed andmuscle ATP content was determinedvia HPLC.提高肝臟功能提高肝臟功能StudiesFrll M., Witteck Th., Gengenbach S., Schmidt B. (2006) :Effects of pre-operative application of butaphosphan and cyanocobalamine on recon

21、valescence clinico-chemical parameters, antioxidavive metabolism and postoperative abomosal emptying in cows with abomosal dislocation.Tierrztl. Prax. 34 (G): 351-356. HASI Su-rong , JIANG Jin-shu, DU Xiao-yan, ZHU Bei-lei (2005a): Anti-cold stress effects and mechanisms of compound butaphosphan sol

22、ution. Progress in Veterinary Medicine, 26, (03), 59-62.HASI Su-rong , JIANG Jin-shu , ZHU Bei-lei , DU Xiao-yan (2005b) : Studies on Anti-heat Stress Effects and Mechanisms of Compound Butafosfan Solution. Acta Veterinaria Et Zootechnica Sinica, 36 (12), 1334-1338.Sommer H., Marx D., und Starker G.

23、 (1971) :Studies to reduce reproductive disorders in cattle by using Catosal as metaphylaxis.Dtsch. Tierrtzl.Wschr. 78, 593 616.Flasshoff F.-H. (1974) :Clinical and chemical blood serum investigations in cattle and treatment studies with ornithine-aspartate-product HMV 20 and with Catosal for the re

24、duction of fertility and health disorders.Doctorate Thesis, Tierrztliche Hochschule Hannover, Germany.Marbach W (1980) :Alkalische Phosphatase (AP) und Aspartataminotransferase (AST) des Blutplasmas als Parameter der Kondition von Rennpferden und die Wirkung von Coforta/Catosal auf diese Enzyme.Vet.

25、 Med. Nahchr., 12.CATOSAL: 營(yíng)養(yǎng)肝臟營(yíng)養(yǎng)肝臟 ASAT (U/l)50100150200250300350Catosal對(duì)照組對(duì)照組 谷草轉(zhuǎn)氨酶(ASAT)是一種線粒體內(nèi)的酶，當(dāng)肝臟或肌肉損傷或肝臟代謝負(fù)擔(dān)過(guò)重是會(huì)釋放到血液中?？铺貕涯艽龠M(jìn)糖異生的過(guò)程，這樣減輕肝臟的負(fù)擔(dān)。0d1d2d3dpost OP科特壯科特壯-藥理作用藥理作用 游離脂肪酸游離脂肪酸 (mol/l)20060010001400180022000d1d2d3dCATOSAL: 營(yíng)養(yǎng)肝臟營(yíng)養(yǎng)肝臟 血液中的游離脂肪酸含量是脂肪代謝的指標(biāo)，脂肪代謝不好時(shí)其含量高 用科特壯治療后游離脂肪酸含量比未治療明顯降

26、低Catosal對(duì)照組對(duì)照組Catosal 藥理作用藥理作用科特壯的成分科特壯的成分VB12 水溶性水溶性,提供鈷元素提供鈷元素 需要不斷攝入需要不斷攝入作用方式作用方式 調(diào)節(jié)蛋白質(zhì)、脂類和碳水化合物的新陳代謝調(diào)節(jié)蛋白質(zhì)、脂類和碳水化合物的新陳代謝 提供鈷元素，幫助紅細(xì)胞合成。提供鈷元素，幫助紅細(xì)胞合成。 促進(jìn)蛋氨酸合成，而蛋氨酸是機(jī)體蛋白質(zhì)重要的合成原料。促進(jìn)蛋氨酸合成，而蛋氨酸是機(jī)體蛋白質(zhì)重要的合成原料。 促進(jìn)身體生長(zhǎng)促進(jìn)身體生長(zhǎng),提高食物利用率。提高食物利用率。 黑色晶體黑色晶體,吸水性吸水性科特壯科特壯-藥理作用藥理作用CATOSAL: 抗氧化作用抗氧化作用布他磷是一種布他磷是一種-氨

27、基磷酸氨基磷酸,可以保護(hù)犬貓機(jī)體免受氧化損傷?？梢员Ｗo(hù)犬貓機(jī)體免受氧化損傷。CATOSAL: 促進(jìn)生長(zhǎng)發(fā)育促進(jìn)生長(zhǎng)發(fā)育布他磷能夠影響寵物的中間代謝（布他磷能夠影響寵物的中間代謝（GIESECKE 1985），主要表現(xiàn)為促進(jìn)能量代謝、提），主要表現(xiàn)為促進(jìn)能量代謝、提高蛋白質(zhì)合成（高蛋白質(zhì)合成（KAEMMERER 1984, KIETZMANN 1986）和促進(jìn)生長(zhǎng)發(fā)育。）和促進(jìn)生長(zhǎng)發(fā)育。實(shí)驗(yàn)證明，給予科特壯、維生素以及硒元素可使動(dòng)物生長(zhǎng)速度提高實(shí)驗(yàn)證明，給予科特壯、維生素以及硒元素可使動(dòng)物生長(zhǎng)速度提高38%（El-Sherif et al., 1981） 。促進(jìn)生長(zhǎng)發(fā)育得益于科特壯能促進(jìn)新陳代謝和提高肌肉的運(yùn)動(dòng)促進(jìn)生長(zhǎng)發(fā)育得益于科特壯能促進(jìn)新陳代謝和提高肌肉的運(yùn)動(dòng)科特壯科特壯-藥理作用藥理作用C