分子細(xì)胞生物學(xué)課程教學(xué)大綱

1、分子細(xì)胞生物學(xué)課程教學(xué)大綱課程基本信息（Course Information）*課程代碼（Course Code）PM201*學(xué)時(shí)（Credit Hours）51*學(xué)分（Credits）3*課程名稱(chēng)（Course Name）（中文）分子細(xì)胞生物學(xué)-概念與應(yīng)用，簡(jiǎn)稱(chēng)分子細(xì)胞生物學(xué)（英文）Molecular Cell Biology-concepts and applications課程性質(zhì)(Course Type)生命學(xué)科專(zhuān)業(yè)基礎(chǔ)課 Foundational for All Areas of life Sciences 授課對(duì)象（Audience）對(duì)生物工程、系統(tǒng)生物學(xué)、農(nóng)業(yè)與生物技術(shù)、醫(yī)學(xué)基礎(chǔ)

2、、藥學(xué)基礎(chǔ)領(lǐng)域的國(guó)際本科生開(kāi)放，并鼓勵(lì)生農(nóng)醫(yī)藥具有較好英語(yǔ)基礎(chǔ)的國(guó)內(nèi)本科生參加。This course is one of the Shanghai Higher Education Model Course for International Students that provide basic understanding of molecular cell biology for all life science related majors including Agricultural, Biological, Medical and Pharmaceutical Sciences.

3、This course is suitable for both undergraduate and graduate studies with different knowledge extension requirements. 授課語(yǔ)言(Language of Instruction)全英語(yǔ) (Fully English)*開(kāi)課院系（School）藥學(xué)院 School of Pharmacy先修課程（Prerequisite）高中生物學(xué)，基礎(chǔ)生物化學(xué)或類(lèi)似課程（Basic Biology, Biochemistry or their equivalents）*授課教師（Instructo

4、r）李大偉 (Prof. Dawei Li)課程網(wǎng)址(Course Webpage) HYPERLINK /lodish7e /lodish7e*課程簡(jiǎn)介（Description）（中文300-500字，含課程性質(zhì)、主要教學(xué)內(nèi)容、課程教學(xué)目標(biāo)等）課程性質(zhì)：生命科學(xué)應(yīng)用基礎(chǔ)課。主要教學(xué)內(nèi)容：分子細(xì)胞生物學(xué)-概念與應(yīng)用課程根據(jù)英文原版教材的框架，輔以國(guó)際高端學(xué)術(shù)期刊，分為五個(gè)部分對(duì)相關(guān)概念與應(yīng)用進(jìn)行探索：1、生命運(yùn)行的化學(xué)與分子基礎(chǔ)與模式生物，2、現(xiàn)代分子遺傳與進(jìn)化的基本原理與概念，3、分子細(xì)胞生物學(xué)的基本研究方法與應(yīng)用，4、細(xì)胞的結(jié)構(gòu)功能與細(xì)胞信號(hào)，5、細(xì)胞生長(zhǎng)發(fā)育與腫瘤。課程突破傳統(tǒng)課程教學(xué)內(nèi)

5、容滯后、應(yīng)用性不足的缺點(diǎn)，教學(xué)內(nèi)容在保持原版教材的系統(tǒng)性框架基礎(chǔ)上，教學(xué)內(nèi)容跟蹤以Nature、Science等權(quán)威雜志的最新相關(guān)文章為代表的國(guó)際學(xué)科前沿每年更新一次。課程教學(xué)目標(biāo)：課程為學(xué)生介紹生命相關(guān)學(xué)科前沿基礎(chǔ)理論概念和探索的原理、方法與現(xiàn)狀，重點(diǎn)培養(yǎng)學(xué)生探索、分析解決生命科學(xué)相關(guān)問(wèn)題的能力，為學(xué)生從事與生命科學(xué)相關(guān)專(zhuān)業(yè)技術(shù)和科學(xué)探索研究工作打下堅(jiān)實(shí)的基礎(chǔ)。*課程簡(jiǎn)介（Description）This inter-disciplinary course combines current core concepts in molecular cell biology and the app

6、lications of these concepts in basic research, as well as translational research and applications in life science related fields. The knowledge organization system of this course is based on the textbook “Molecular Cell Biology-Concepts and Applications” widely used around the world, with up-to-date

7、 knowledge extensions supported by recent advancements reported in peer-reviewed high impact journals, such as Science and Nature. There are five major parts in this course: 1. The Chemical and Molecular Basis of Life and Model Organisms. 2. Molecular Genetics and Current Concepts of Evolution. 3. B

8、asic Molecular Genetic Techniques and Applications. 4. Cell Structure, Function And Cell Signaling. 5. Cell growth, Development And Cancer. This course follows the knowledge framework of a well known textbook. In addition, this course is complemented by the recent discoveries to reflect current tren

9、d in the development of molecular biology that is renewed each year. The goal of this course is to encourage students to explore new knowledge, to analyze and explain experimental data, and to apply these abilities in their future work through introduce the basic knowledge and cutting-edge concepts

10、focusing on the current applications of these knowledge and concepts. 課程教學(xué)大綱（course syllabus）*學(xué)習(xí)目標(biāo)(Learning Outcomes)1、生命運(yùn)行的化學(xué)與分子基礎(chǔ)與模式生物：A.復(fù)習(xí)了解化學(xué)小分子與生物大分子在生命運(yùn)行中的化學(xué)原理與模式生物概念及應(yīng)用；B.熟悉生物大分子結(jié)構(gòu)與功能的關(guān)系；C.理解什么是同行評(píng)議的科學(xué)文獻(xiàn)并掌握信息獲取途徑。2、現(xiàn)代分子遺傳與進(jìn)化的基本原理與概念：A.理解基因的概念，熟悉基因結(jié)構(gòu)與基因組的關(guān)系；B.掌握從基因到細(xì)胞功能的基本運(yùn)行原理；C. 了解常見(jiàn)的基因表達(dá)調(diào)控方式

11、與機(jī)制。D.通過(guò)文獻(xiàn)了解基因研究應(yīng)用的進(jìn)展。3、分子細(xì)胞生物學(xué)的基本研究方法與應(yīng)用：A. 熟悉基因克隆的概念、常用技術(shù)及其應(yīng)用；B.熟悉研究蛋白表達(dá)、調(diào)控與純化的常見(jiàn)技術(shù)與應(yīng)用；C.熟悉RNA相關(guān)技術(shù)的原理與應(yīng)用。D.通過(guò)文獻(xiàn)了解生物技術(shù)轉(zhuǎn)化應(yīng)用的最新進(jìn)展。4、細(xì)胞的結(jié)構(gòu)功能與細(xì)胞信號(hào)：A.熟悉細(xì)胞水平研究的主要技術(shù)方法；B.了解細(xì)胞內(nèi)部結(jié)構(gòu)與細(xì)胞功能的關(guān)系；C.理解掌握細(xì)胞間相互作用的分子信號(hào)概念與作用原理；D.通過(guò)文獻(xiàn)了解細(xì)胞信號(hào)研究的最新進(jìn)展。5、細(xì)胞生長(zhǎng)發(fā)育與腫瘤：A.熟悉理解細(xì)胞周期的概念和調(diào)控原理，以及細(xì)胞的產(chǎn)生分化與死亡過(guò)程； B.了解發(fā)育的細(xì)胞分子生物學(xué)原理和概念；C. 了解神

12、經(jīng)與免疫系統(tǒng)基本知識(shí)與概念；D.理解腫瘤的概念與可能的產(chǎn)生機(jī)制，了解抗腫瘤研究的前沿進(jìn)展。*教學(xué)內(nèi)容、進(jìn)度安排及要求(Class Schedule& Requirements)教學(xué)內(nèi)容學(xué)時(shí)教學(xué)方式作業(yè)及要求基本要求考查方式1、生命運(yùn)行的化學(xué)與分子基礎(chǔ)與模式生物6面授習(xí)題完成書(shū)面2、現(xiàn)代分子遺傳與進(jìn)化的基本原理與概念12面授/研討習(xí)題/poster完成書(shū)面/展示/點(diǎn)評(píng)3、分子細(xì)胞生物學(xué)的基本研究方法與應(yīng)用12面授/研討習(xí)題/Poster完成書(shū)面/展示/點(diǎn)評(píng)4、細(xì)胞的結(jié)構(gòu)功能與細(xì)胞信號(hào)12面授/報(bào)告Poster/PPTreport完成展示/報(bào)告/點(diǎn)評(píng)5、細(xì)胞生長(zhǎng)發(fā)育與腫瘤10面授/報(bào)告Poster

13、/PPTreport完成展示/報(bào)告/點(diǎn)評(píng)總結(jié)考核2開(kāi)卷試卷獨(dú)立完成考卷*考核方式(Grading)（成績(jī)構(gòu)成）作業(yè)：50%， Final Exam：50%Homework 50% Final Exam50% *教材或參考資料(Textbooks & Other Materials)（必含信息：教材名稱(chēng)，作者，出版社，出版年份，版次，書(shū)號(hào)）1. The textbook（課程主要教材）: Molecular Cell Biology, 6th Edition, Lodish et al. (W.H. Freeman, 2008)2. The reference book（課程參考書(shū)）: Molecular Biology of the Cell, 5th Edition, Bruce Alberts (Garland Science, 2008)3. Current References: Selec