Thyroid-Hormone-Receptor-Agonists-Modulators-MCE

1、 HYPERLINK https:/www.MedChemE/Targets/Thyroid Hormone Receptor.html Thyroid HYPERLINK https:/www.MedChemE/Targets/Thyroid Hormone Receptor.html HYPERLINK https:/www.MedChemE/Targets/Thyroid Hormone Receptor.html Hormone HYPERLINK https:/www.MedChemE/Targets/Thyroid Hormone Receptor.html HYPERLINK h

2、ttps:/www.MedChemE/Targets/Thyroid Hormone Receptor.html ReceptorTHRThyroid hormone receptor is a member of the nuclear receptor superfamily that shuttles between the cytosol and nucleus. Thyroidhormone receptors are ligand-dependent transcription factors that mediate the biological activities of th

3、yroid hormone (T3).Thyroid hormone receptors are encoded by two genes, one for TR and another for TR, which encode the major isoforms of TR,including TR1, TR2, TR1, and TR2. The thyroid hormone receptors mediate the pleiotropic activities of the thyroid hormone(T3) in growth, development, and differ

4、entiation and in maintaining metabolic homeostasis.Thyroid hormone receptors are zinc finger transcription factors in the erbA superfamily that bind DNA at specific response elementsequences (thyroid hormone response elements, TREs) and activate gene expression in response to thyroid hormone (T3). T

5、hyroidhormone receptors have been shown to bind DNA as monomers, homodimers, or heterodimers with another erbA superfamilymember, the retinoid X receptor (RXR).www.MedChemE 1 HYPERLINK https:/www.MedChemE/Targets/Thyroid Hormone Receptor.html Thyroid HYPERLINK https:/www.MedChemE/Targets/Thyroid Hor

6、mone Receptor.html HYPERLINK https:/www.MedChemE/Targets/Thyroid Hormone Receptor.html Hormone HYPERLINK https:/www.MedChemE/Targets/Thyroid Hormone Receptor.html HYPERLINK https:/www.MedChemE/Targets/Thyroid Hormone Receptor.html Receptor HYPERLINK https:/www.MedChemE/Targets/Thyroid Hormone Recept

7、or.html HYPERLINK https:/www.MedChemE/Targets/Thyroid Hormone Receptor.html Inhibitors, HYPERLINK https:/www.MedChemE/Targets/Thyroid Hormone Receptor.html HYPERLINK https:/www.MedChemE/Targets/Thyroid Hormone Receptor.html Agonists, HYPERLINK https:/www.MedChemE/Targets/Thyroid Hormone Receptor.htm

8、l HYPERLINK https:/www.MedChemE/Targets/Thyroid Hormone Receptor.html Antagonists, HYPERLINK https:/www.MedChemE/Targets/Thyroid Hormone Receptor.html HYPERLINK https:/www.MedChemE/Targets/Thyroid Hormone Receptor.html Activators HYPERLINK https:/www.MedChemE/Targets/Thyroid Hormone Receptor.html HY

9、PERLINK https:/www.MedChemE/Targets/Thyroid Hormone Receptor.html & HYPERLINK https:/www.MedChemE/Targets/Thyroid Hormone Receptor.html HYPERLINK https:/www.MedChemE/Targets/Thyroid Hormone Receptor.html Modulators HYPERLINK https:/www.MedChemE/d-trp12-tyr34-pth-7-34-amide-bovine.html (D-Trp12,Tyr34

10、)-pTH HYPERLINK https:/www.MedChemE/d-trp12-tyr34-pth-7-34-amide-bovine.html HYPERLINK https:/www.MedChemE/d-trp12-tyr34-pth-7-34-amide-bovine.html (7-34) HYPERLINK https:/www.MedChemE/d-trp12-tyr34-pth-7-34-amide-bovine.html HYPERLINK https:/www.MedChemE/d-trp12-tyr34-pth-7-34-amide-bovine.html ami

11、de HYPERLINK https:/www.MedChemE/d-trp12-tyr34-pth-7-34-amide-bovine.html HYPERLINK https:/www.MedChemE/d-trp12-tyr34-pth-7-34-amide-bovine.html (bovine) HYPERLINK https:/www.MedChemE/d-trp12-tyr34-pth-7-34-amide-bovine.html HYPERLINK https:/www.MedChemE/1-hydroxy-3-epi-vitamin-d3.html 1-Hydroxy-3-e

12、pi-vitamin HYPERLINK https:/www.MedChemE/1-hydroxy-3-epi-vitamin-d3.html HYPERLINK https:/www.MedChemE/1-hydroxy-3-epi-vitamin-d3.html D3Cat. No.: HY-P2426 Cat. No.: HY-10003A(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) is apotent and competitive antagonist of parathyroidhormone (PTH), with a K of 69 n

13、M in bovine renalicortical membrane. (D-Trp12,Tyr34)-pTH (7-34)amide (bovine) can be used for growth anddevelopment regulation.1-Hydroxy-3-epi-vitamin D3, a natural metaboliteof 1alpha,25-dihydroxyvitamin D3, is a potentsuppressor of parathyroid hormone (PTH)secretion.Purity: 99.12%Clinical Data: No

14、 Development ReportedSize: 1 mg, 5 mg, 10 mgPurity: 99.30%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mg HYPERLINK https:/www.MedChemE/3-5-diiodothyropropionic-acid.html 3,5-Diiodothyropropionic HYPERLINK https:/www.MedChemE/3-5-diiodothyropropionic-acid.html HYPERLINK https:/www.MedC

15、hemE/3-5-diiodothyropropionic-acid.html acidCat. No.: HY-126236 HYPERLINK https:/www.MedChemE/abaloparatide-tfa.html Abaloparatide HYPERLINK https:/www.MedChemE/abaloparatide-tfa.html HYPERLINK https:/www.MedChemE/abaloparatide-tfa.html TFA(BA 058 TFA; BIM 44058 TFA) Cat. No.: HY-108742A3,5-Diiodoth

16、yropropionic acid is a thyroid hormoneanalog, induces -myosin heavy chain mRNAexpression, binds to thyroid hormone receptor(TR), with K of 2.40 and 4.06 M-1 for TR1aand TR1, respectively.Abaloparatide TFA (BA 058 TFA) is a parathyroidhormone receptor 1 (PTHR1) analogue selected tobe a potent and sel

17、ective activator of the PTHR1signaling pathway.Purity: 99.20%Clinical Data:Size: 5 mg, 10 mg, 25 mg, 50 mgPurity: 96.11%Clinical Data: LaunchedSize: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/co23.html CO23Cat. No.: HY-130012 HYPERLINK https:/www.MedChemE/debutyldronedarone-hydr

18、ochloride.html Debutyldronedarone HYPERLINK https:/www.MedChemE/debutyldronedarone-hydrochloride.html HYPERLINK https:/www.MedChemE/debutyldronedarone-hydrochloride.html hydrochloride(SR35021 hydrochloride) Cat. No.: HY-12753ACO23 is a selective thyroid hormone receptor (TR) agonist and used for gro

19、wth and developmentregulation. CO23 was able to be transportedthrough the blood-brain barrier.Debutyldronedarone (SR35021) hydrochloride, themain metabolite of Dronedarone, is a selectivethyroid hormone receptor 1 (TR1) inhibitor.Debutyldronedarone hydrochloride inhibits T3binding to TR1 and TR1 by

20、77% and 25%,respectively.Purity: 98%Clinical Data:Size: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/dpc-aj1951.html DPC-AJ1951 HYPERLINK https:/www.MedChemE/dpc-aj1951.html HYPERLINK https:/www.MedChemE/dpc-aj1951-tfa.html DPC-AJ1951 HYPE

21、RLINK https:/www.MedChemE/dpc-aj1951-tfa.html HYPERLINK https:/www.MedChemE/dpc-aj1951-tfa.html TFACat. No.: HY-P1418 Cat. No.: HY-P1418ADPC-AJ1951, a 14 amino acid peptide that acts as apotent agonist of the parathyroid hormone(PTH)/PTH-related peptide receptor (PPR). Andcharacterized the activity

22、of DPC-AJ1951 in exvivo and in vivo assays of bone resorption.DPC-AJ1951 TFA, a 14 amino acid peptide that actsas a potent agonist of the parathyroid hormone(PTH)/PTH-related peptide receptor (PPR). Andcharacterized the activity of DPC-AJ1951 TFA in exvivo and in vivo assays of bone resorption.Purit

23、y: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/ds08210767.html DS08210767 HYPERLINK https:/www.MedChemE/ds08210767.html HYPERLINK https:/www.MedChemE/Eprotirome.html EprotiromeCat. No.: HY-12

24、5879(KB2115) Cat. No.: HY-10473DS08210767 is a highly potent, orally bioavailablePTHR1 antagonist with IC of 90 nM.50Eprotirome (KB2115) is a liver-selective thyroidhormone receptor (TR) agonist. KB2115 hasmodestly higher affinity for TR than for TR.Eprotirome reduces low-density lipoprotein (LDL)ch

25、olesterol concentrations. Eprotirome can be usedfor dyslipidemias and obesity research.Purity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg, 50 mg, 100 mgPurity: 99.77%Clinical Data: Phase 3Size: 1 mg2 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www

26、.MedChemE/GC_14.html GC HYPERLINK https:/www.MedChemE/GC_14.html HYPERLINK https:/www.MedChemE/GC_14.html 14Cat. No.: HY-111442 HYPERLINK https:/www.MedChemE/glutaurine.html Glutaurine(Litoralon) Cat. No.: HY-106608GC 14 is a selective thyroid hormone receptorantagonist, with IC values of 35 nM and

27、200 nM50for hTR and hTR, respectively.Glutaurine containing glutamine and taurineresidues is an orally active hormone of theparathyroid. Glutaurine, as a hormone, is isolatedfrom parathyroid gland oxyphil cells. Glutaurinecan be used for the research of antiepileptic andanti-amnesia.Purity: 98%Clini

28、cal Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 50 mg HYPERLINK https:/www.MedChemE/KAT681.html KAT681(T0681) Cat. No.: HY-U00220 HYPERLINK https:/www.MedChemE/l-thyroxine.html L-Thyroxine(Levothyroxine; T4) Cat. No.: HY-18341KAT68

29、1 is a liver-selective thyromimetic.L-Thyroxine (Levothyroxine; T4) is a synthetichormone for the research of hypothyroidism. DIOenzymes convert biologically active thyroidhormone (Triiodothyronine,T3) from L-Thyroxine(T4).Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98.6

30、0%Clinical Data: LaunchedSize: 10 mM 1 mL, 500 mg HYPERLINK https:/www.MedChemE/l-thyroxine-sodium.html L-Thyroxine HYPERLINK https:/www.MedChemE/l-thyroxine-sodium.html HYPERLINK https:/www.MedChemE/l-thyroxine-sodium.html sodium(Levothyroxine sodium; T4 sodium) Cat. No.: HY-18341B HYPERLINK https:

31、/www.MedChemE/L-Thyroxine-sodium-salt-pentahydrate.html L-Thyroxine HYPERLINK https:/www.MedChemE/L-Thyroxine-sodium-salt-pentahydrate.html HYPERLINK https:/www.MedChemE/L-Thyroxine-sodium-salt-pentahydrate.html sodium HYPERLINK https:/www.MedChemE/L-Thyroxine-sodium-salt-pentahydrate.html HYPERLINK

32、 https:/www.MedChemE/L-Thyroxine-sodium-salt-pentahydrate.html salt HYPERLINK https:/www.MedChemE/L-Thyroxine-sodium-salt-pentahydrate.html HYPERLINK https:/www.MedChemE/L-Thyroxine-sodium-salt-pentahydrate.html pentahydrate(Sodium levothyroxine pentahydrate) Cat. No.: HY-18341AL-Thyroxine sodium (L

33、evothyroxine sodium) is asynthetic hormone for the research ofhypothyroidism. DIO enzymes convert biologicallyactive thyroid hormone (Triiodothyronine,T3) fromL-Thyroxine (T4).L-Thyroxine sodium salt pentahydrate(Levothyroxine; T4) is a synthetic hormone for theresearch of hypothyroidism. DIO enzyme

34、s convertbiologically active thyroid hormone(Triiodothyronine,T3) from L-Thyroxine (T4).Purity: 99.50%Clinical Data: LaunchedSize: 10 mM 1 mL, 500 mg, 1 gPurity: 99.38%Clinical Data: LaunchedSize: 10 mM 1 mL, 500 mg, 1 g HYPERLINK https:/www.MedChemE/3,3_acute_,5-Triiodo-L-thyronine.html Liothyronin

35、e HYPERLINK https:/www.MedChemE/3,3_acute_,5-Triiodo-L-thyronine.html HYPERLINK https:/www.MedChemE/3,3_acute_,5-Triiodo-L-thyronine-sodium.html Liothyronine HYPERLINK https:/www.MedChemE/3,3_acute_,5-Triiodo-L-thyronine-sodium.html HYPERLINK https:/www.MedChemE/3,3_acute_,5-Triiodo-L-thyronine-sodi

36、um.html sodium HYPERLINK https:/www.MedChemE/3,3_acute_,5-Triiodo-L-thyronine-sodium.html (Triiodothyronine sodium;(Triiodothyronine; 3,3,5-Triiodo-L-thyronine; T3) Cat. No.: HY-A0070A 3,3,5-Triiodo-L-thyronine sodium; T3 sodium) Cat. No.: HY-A0070Liothyronine is an active form of thyroid hormone.Li

37、othyronine is a potent thyroid hormone receptorsTR and TR agonist with Ks of 2.33 nM for hTRiand hTR, respectively.Liothyronine sodium is an active form of thyroidhormone, which binds to 1 thyroid hormonereceptor (TR1), and activates its activity.Purity: 99.82%Clinical Data: LaunchedSize: 10 mM 1 mL

38、, 100 mg, 500 mgPurity: 99.17%Clinical Data: LaunchedSize: 100 mg, 500 mg HYPERLINK https:/www.MedChemE/nh-3.html NH-3 HYPERLINK https:/www.MedChemE/nh-3.html HYPERLINK https:/www.MedChemE/parathyroid-hormone-1-34-rat.html Parathyroid HYPERLINK https:/www.MedChemE/parathyroid-hormone-1-34-rat.html H

39、YPERLINK https:/www.MedChemE/parathyroid-hormone-1-34-rat.html hormone HYPERLINK https:/www.MedChemE/parathyroid-hormone-1-34-rat.html HYPERLINK https:/www.MedChemE/parathyroid-hormone-1-34-rat.html (1-34) HYPERLINK https:/www.MedChemE/parathyroid-hormone-1-34-rat.html HYPERLINK https:/www.MedChemE/

40、parathyroid-hormone-1-34-rat.html (rat)Cat. No.: HY-141513 Cat. No.: HY-P2279NH-3 is an orally active, reversible thyroidhormone receptor (THR) antagonist with an IC of5055 nM. NH-3, a derivative of the selectivethyromi-metic GC-1, inhibits binding of thyroidhormones to their receptor and that inhib

41、itscofactor recruitment.Parathyroid hormone (1-34) (rat) improves bothcortical and cancellous bone structure.Purity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg, 50 mg, 100 mgPurity: 95.53%Clinical Data: No Development ReportedSize: 1 mg, 5 mgwww.MedChemE 3 HYPERLINK https:/www

42、.MedChemE/parathyroid-hormone-1-34-bovine.html Parathyroid HYPERLINK https:/www.MedChemE/parathyroid-hormone-1-34-bovine.html HYPERLINK https:/www.MedChemE/parathyroid-hormone-1-34-bovine.html Hormone HYPERLINK https:/www.MedChemE/parathyroid-hormone-1-34-bovine.html HYPERLINK https:/www.MedChemE/pa

43、rathyroid-hormone-1-34-bovine.html (1-34), HYPERLINK https:/www.MedChemE/parathyroid-hormone-1-34-bovine.html HYPERLINK https:/www.MedChemE/parathyroid-hormone-1-34-bovine.html bovine HYPERLINK https:/www.MedChemE/parathyroid-hormone-1-34-bovine.html HYPERLINK https:/www.MedChemE/parathyroid-hormone

44、-1-34-bovine-tfa.html Parathyroid HYPERLINK https:/www.MedChemE/parathyroid-hormone-1-34-bovine-tfa.html HYPERLINK https:/www.MedChemE/parathyroid-hormone-1-34-bovine-tfa.html Hormone HYPERLINK https:/www.MedChemE/parathyroid-hormone-1-34-bovine-tfa.html HYPERLINK https:/www.MedChemE/parathyroid-hor

45、mone-1-34-bovine-tfa.html (1-34), HYPERLINK https:/www.MedChemE/parathyroid-hormone-1-34-bovine-tfa.html HYPERLINK https:/www.MedChemE/parathyroid-hormone-1-34-bovine-tfa.html bovine HYPERLINK https:/www.MedChemE/parathyroid-hormone-1-34-bovine-tfa.html HYPERLINK https:/www.MedChemE/parathyroid-horm

46、one-1-34-bovine-tfa.html TFACat. No.: HY-P1252 Cat. No.: HY-P1252AParathyroid Hormone (1-34), bovine is a potentparathyroid hormone (PTH) receptor agonist.Parathyroid Hormone (1-34), bovine increasescalcium and inorganic phosphate levels in vivo.Parathyroid Hormone (1-34), bovine can be used forth r

47、eseach of osteoporosis.Parathyroid Hormone (1-34), bovine TFA is a potentparathyroid hormone (PTH) receptor agonist.Parathyroid Hormone (1-34), bovine increasescalcium and inorganic phosphate levels in vivo.Parathyroid Hormone (1-34), bovine can be used forth reseach of osteoporosis.Purity: 98%Clini

48、cal Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/parathyroid-hormone-1-34-human-biotinylated.html Parathyroid HYPERLINK https:/www.MedChemE/parathyroid-hormone-1-34-human-biotinylated.html HYPERLINK https

49、:/www.MedChemE/parathyroid-hormone-1-34-human-biotinylated.html Hormone HYPERLINK https:/www.MedChemE/parathyroid-hormone-1-34-human-biotinylated.html HYPERLINK https:/www.MedChemE/parathyroid-hormone-1-34-human-biotinylated.html (1-34), HYPERLINK https:/www.MedChemE/parathyroid-hormone-1-34-human-b

50、iotinylated.html HYPERLINK https:/www.MedChemE/parathyroid-hormone-1-34-human-biotinylated.html human, HYPERLINK https:/www.MedChemE/parathyroid-hormone-1-34-human-biotinylated.html HYPERLINK https:/www.MedChemE/parathyroid-hormone-1-34-human-biotinylated.html biotinylated HYPERLINK https:/www.MedCh

51、emE/parathyroid-hormone-1-34-human-biotinylated.html HYPERLINK https:/www.MedChemE/PCO371.html PCO371Cat. No.: HY-P2510 Cat. No.: HY-100856Parathyroid Hormone (1-34), human, biotinylated isa probe for the parathyroid hormone receptor, canbe used for analyzing the interaction betweenparathyroid hormo

52、ne and parathyroid hormonereceptors in living cells and for purifyinghormone-receptor complexes with affinity columns.PCO371 is an orally active full agonist ofparathyroid hormone receptor 1 (PTHR1), with noeffect on PTH type 2 receptor.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5

53、mgPurity: 98.54%Clinical Data: Phase 1Size: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/Protirelin.html Protirelin(Thyrotropin-releasing-hormone; TRH) Cat. No.: HY-P0002 HYPERLINK https:/www.MedChemE/Protirelin-Acetate.html Protirelin HYPERLINK https:/www.MedChemE/Pro

54、tirelin-Acetate.html HYPERLINK https:/www.MedChemE/Protirelin-Acetate.html acetate(Thyrotropin-releasing-hormone acetate; TRH acetate) Cat. No.: HY-P0002AProtirelin is a highly conserved neuropeptide thatexerts the hormonal control of thyroid-stimulatinghormone (TSH) levels as well as neuromodulator

55、yfunctions.Protirelin Acetate is a highly conservedneuropeptide that exerts the hormonal control ofthyroid-stimulating hormone (TSH) levels as wellas neuromodulatory functions.Purity: 98%Clinical Data: LaunchedSize: 5 mg, 10 mg, 25 mgPurity: 99.98%Clinical Data: LaunchedSize: 10 mM 1 mL, 10 mg, 50 m

56、g, 100 mg HYPERLINK https:/www.MedChemE/MGL-3196.html Resmetirom HYPERLINK https:/www.MedChemE/MGL-3196.html HYPERLINK https:/www.MedChemE/reverse-t3.html Reverse HYPERLINK https:/www.MedChemE/reverse-t3.html HYPERLINK https:/www.MedChemE/reverse-t3.html T3(MGL-3196; VIA-3196) Cat. No.: HY-12216 (3,

57、5,3-Triiodothyronine) Cat. No.: HY-W010696Resmetirom (MGL-3196) is a highly selectivethyroid hormone receptor (THR-) agonist withan EC value of 0.21 M.50Reverse T3 is a thyroid hormone generated bydeiodination of the prohormone thyroxine. ReverseT3 inhibits the increase of sodium currentgenerated by

58、 other thyroid hormone analogs inneonatal rat myocytes.Purity: 99.71%Clinical Data: Phase 3Size: 10 mM 1 mL, 2 mg, 5 mg, 10 mg, 50 mg, 100 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/Sobetirome.html Sobetirome HYPERLINK https:/www.MedChemE/Sobeti

59、rome.html HYPERLINK https:/www.MedChemE/t3-ata-s-isomer.html T3-ATA HYPERLINK https:/www.MedChemE/t3-ata-s-isomer.html HYPERLINK https:/www.MedChemE/t3-ata-s-isomer.html (S-isomer)(GC-1; QRX-431) Cat. No.: HY-14823Cat. No.: HY-114271ASobetirome (GC-1) is a thyroid hormone receptor (TR)-specific agon

60、ist which bind selectively toTR-1 with an EC of 0.16 M.50T3-ATA S-isomer is the S-isomer of T3-ATA, whichis the active form of the thyroid hormone.Purity: 99.79%Clinical Data: Phase 2Size: 10 mM 1 mL, 5 mg, 10 mg, 50 mgPurity: 99.50%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 1 mg, 5 mg,