孕酮作用機制 - Medchemexpress - MCE中國

1、Product Data SheetProgesteroneCat. No.: HY-N0437CAS No.: 57-83-0分式: CHO分量: 314.46作靶點: Progesterone Receptor; Endogenous Metabolite作通路: Others; Metabolic Enzyme/Protease儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 50 mg/mL (159.00 mM; Need ultrasonic)H2O : 0.

2、1 mg/mL (insoluble)SolventMass1 mg 5 mg 10 mgConcentration制備儲備液1 mM 3.1801 mL 15.9003 mL 31.8005 mL5 mM 0.6360 mL 3.1801 mL 6.3601 mL10 mM 0.3180 mL 1.5900 mL 3.1801 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存式和期限：-80C, 6 months; -20C, 1 month。-80C 儲存時，請在 6 個內(nèi)使，-20C 儲存時，請在 1 個內(nèi)使。體

3、內(nèi)實驗請根據(jù)您的實驗動物和給藥式選擇適當(dāng)?shù)娜芙獍浮Ｒ韵氯芙獍付颊埾劝凑?In Vitro 式配制澄清的儲備液，再依次添加助溶劑：為保證實驗結(jié)果的可靠性，澄 的儲備液可以根據(jù)儲存條件，適當(dāng)保存；體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使； 以下溶劑前顯的百分 指該溶劑在您配制終溶液中的體積占；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的式助溶1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (6.61 mM); Clear solution此案可獲得 2.08 mg/mL (6.6

4、1 mM，飽和度未知) 的澄清溶液。以 1 mL 作液為例，取 100 L 20.8 mg/mL 的澄 DMSO 儲備液加到 400 L PEG300 中，混合均勻；向上述體系中加50 L Tween-80，混合均勻；然后繼續(xù)加 450 L 理鹽定容 1 mL。2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (6.61 mM); Clear solutionPage 1 of 2 www.MedChemE此案可獲得 2.08 mg/mL (6.61 mM，飽和度未知) 的澄清溶液。以 1 mL 作液

5、為例，取 100 L 20.8 mg/mL 的澄 DMSO 儲備液加到 900 L 20% 的 SBE-CD 理鹽溶液中，混合均勻。3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (6.61 mM); Clear solution此案可獲得 2.08 mg/mL (6.61 mM，飽和度未知) 的澄 溶液，此案不適于實驗周 期在半個以上的實驗。以 1 mL 作液為例，取 100 L 20.8 mg/mL 的澄 DMSO 儲備液加到 900 L 油中，混合均勻。BIOLOGICAL ACTIVITY物活性 Progesteron

6、e種類 醇激素，可調(diào)節(jié)經(jīng)周 期，對懷孕很重要。IC & Target Human Endogenous Metabolite體內(nèi)研究 Progesterone (Injections; 1 mg; three consecutive daily) stimulates vessel maturation in the mouse endometrium4.Animal Model: Adult female mice (7-13 wk, 18-28 g)4Dosage: 1 mgAdministration: Injections; three consecutive dailyResult:

7、 Stimulated vessel maturation in the mouse endometrium.戶使本產(chǎn)品發(fā)表的科研獻(xiàn) Hum Reprod. 2019 May 1;34(5):804-812. Eur J Med Chem. 2019 Mar 22;171:265-281. J Neurosci Methods. 2018 Sep 1;307:240-247. Patent. US20200129476A1 Patent. US20200078369A1See more customer validations on HYPERLINK www.MedChemE www.Med

8、ChemEREFERENCES1. Schindler AE, et al. Classification and pharmacology of progestins. Maturitas. 2003 Dec 10;46 Suppl 1:S7-S16.2. Zava DT, et al. Estrogen and progestin bioactivity of foods, herbs, and spices. Proc Soc Exp Biol Med. 1998 Mar;217(3):369-78.3. Komesaroff PA, et al. Effects of wild yam

9、 extract on menopausal symptoms, lipids and sex hormones in healthy menopausal women. Climacteric. 2001Jun;4(2):144-50.4. Girling JE, et al. Progesterone, but not estrogen, stimulates vessel maturation in the mouse endometrium. Endocrinology. 2007 Nov;148(11):5433-41.Epub 2007 Aug 9.McePdfHeightPage 2 of 3 www.MedChemECaution: Product has not been fully validated for medical applications. Fo