Macropa-NH2-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMacropa-NH2Cat. No.: HY-111895CAS No.: 2146095-13-6分式: CHNO分量: 547.6作靶點(diǎn): Others作通路: Others儲(chǔ)存式: Please store the product under the recommended conditions inthe COA.溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 83.33 mg/mL (152.17 mM; Need ultrasonic)Mass Sol

2、vent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 1.8262 mL 9.1308 mL 18.2615 mL5 mM 0.3652 mL 1.8262 mL 3.6523 mL10 mM 0.1826 mL 0.9131 mL 1.8262 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑

3、在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (3.80 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (3.80 mM); Clear solution3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (3.80 mM); Clear solutionBI

4、OLOGICAL ACTIVITY1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE物活性 Macropa-NH2是Macropa-NCS 的前體。Macropa-NCS能與曲妥珠單抗以及前列腺特異性膜抗原靶向化合物RPS-070結(jié)合， 種可應(yīng)于治療軟組織轉(zhuǎn)移瘤的放射性核素 1 2。REFERENCES1. Thiele NA, et al. An Eighteen-Membered Macrocyclic Ligand for Actinium-225 Targeted Alpha Therapy. Angew Chem Int Ed Engl. 2017Nov 13;56(46):14712-14717.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax