Coenzyme-Q9-Ubiquinone-Q9-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECoenzyme Q9Cat. No.: HY-101415CAS No.: 303-97-9Synonyms: Ubiquinone Q9; CoQ9; Ubiquinone 9分式: CHO分量: 795.23作靶點(diǎn): Endogenous Metabolite作通路: Metabolic Enzyme/Protease儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1

2、month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 5 mg/mL (6.29 mM; Need ultrasonic)H2O : 0.1 mg/mL (insoluble)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 1.2575 mL 6.2875 mL 12.5750 mL5 mM 0.2515 mL 1.2575 mL 2.5150 mL10 mM - - -請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Coenzyme Q9含9個(gè)異戊烯 的泛素， 漿

3、的正常成分。IC50 & Target Human Endogenous Metabolite體外研究Both CoQ9 and CoQ10 are equally cardioprotective, as evidenced by their abilities to improve left ventricular1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEperformance and to reduce myocardial infarct size and cardiomyocyte apoptosis. HPLC analysi

4、s reveals thata substantial portion of CoQ9 has been converted into CoQ10 1. CoQ10 and CoQ9 are components ofthemitochondrial respiratory chain in mammals and can regulate some mitochondrial proteins/functions.Soybean, corn, and rapeseed oils are very rich sources of CoQ10, whereas CoQ9 has been fou

5、nd in highconcentrations in corn oil 2.體內(nèi)研究 The lack of a functional CoQ9 protein in homozygous CoQ9 mutant (CoQ9(X/X) mice causes a severereduction in the CoQ7 protein and a widespread CoQ deficiency and accumulation of demethoxyubiquinone.The deficit in CoQ induces a brain-specific impairment of m

6、itochondrial bioenergetics performance, areduction in respiratory control ratio, ATP levels and ATP/ADP ratio and specific loss of respiratory complex I.These effects lead to neuronal death and demyelinization with severe vacuolization and astrogliosis in thebrain of CoQ9 (X/X) mice that consequentl

7、y die between 3 and 6 months of age 3.REFERENCES1. Lekli I, et al. Coenzyme Q9 provides cardioprotection after converting into coenzyme Q10. J Agric Food Chem. 2008 Jul 9;56(13):5331-7.2. Venegas C, et al. Determination of coenzyme Q10, coenzyme Q9, and melatonin contents in virgin argan oils: compa

8、rison with otheredible vegetable oils. J Agric Food Chem. 2011 Nov 23;59(22):12102-8.3. Garca-Corzo L, et al. Dysfunctional Coq9 protein causes predominant encephalomyopathy associated with CoQ deficiency. Hum MolGenet. 2013 Mar 15;22(6):1233-48.McePdfHeightCaution: Product has not been fully validated for medical applications.Fo