6-Biopterin-L-Biopterin-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE6-BiopterinCat. No.: HY-102015CAS No.: 22150-76-1Synonyms: L-Biopterin分式: CHNO分量: 237.22作靶點: NO Synthase; Endogenous Metabolite作通路: Immunology/Inflammation; Metabolic Enzyme/Protease儲存式: Powder -20C 3 years4C 2 yearsIn solvent -

2、80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 6 mg/mL (25.29 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 4.2155 mL 21.0775 mL 42.1550 mL5 mM 0.8431 mL 4.2155 mL 8.4310 mL10 mM 0.4215 mL 2.1077 mL 4.2155 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗 請根據(jù)您的實驗動物和給藥式選擇適當(dāng)?shù)娜芙獍?，配?/p>

3、前請先配制澄清的儲備液，再依次添加助溶劑(為保證實驗結(jié)果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 1 mg/mL (4.22 mM); Suspended solution; Need ultrasonic2. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 1 mg/mL (4.22 mM); Suspended sol

4、ution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 6-Biopterin (L-Biopterin)，種蝶呤衍物，氧化氮合酶 (NO synthase) 輔因。IC50 & Target Human Endogenous Metabolite體外研究 6-biopterin is extremely cytotoxic to human melanocytes under in vitro conditions. Thioredoxin reductase hasthe capacity t

5、o reduce 6-biopterin to q-BH2 where further reduction to 6-BH4 follows via dihydropteridinereductase or reduced glutathione. (6R)5,6,7,8 tetrahydrobiopterin undergoes redox-cycling by its oxidation toquinonoid dihydrobiopterin and to 6-biopterin through consecutive two electron oxidation reactions 1.REFERENCES1. Schallreuter KU, et al. Cytotoxicity of 6-biopterin to human melanocytes. Biochem Biophys Res Commun. 1994 Oct 14;204(1):43-8.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-37