Azelnidipine-CS-905-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAzelnidipineCat. No.: HY-B0023CAS No.: 123524-52-7Synonyms: CS 905分式: CHNO分量: 582.65作靶點(diǎn): Calcium Channel作通路: Membrane Transporter/Ion Channel; Neuronal Signaling儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 mo

2、nth溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 100 mg/mL (171.63 mM)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (4.29 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 Azelnidipine(CS 905; Calblock)氫吡啶衍物，為L型鈣離通道阻斷劑，可抗壓。REFERENCES1. Komoda H, Inoue T, Node K. Anti-infla

3、mmatory properties of azelnidipine, a dihydropyridine-based calcium channel blocker. Clin ExpHypertens. 2010 Jan;32(2):121-8.2. Kain V, Kumar S, Sitasawad SL. Azelnidipine prevents cardiac dysfunction in streptozotocin-diabetic rats by reducing intracellularcalcium accumulation, oxidative stress and

4、 apoptosis. Cardiovasc Diabetol. 2011 Nov 4;10:97.3. Takano Y, Ueyama T, Ishikura F. Azelnidipine, unique calcium channel blocker could prevent stress-induced cardiac dysfunction like blocker. J Cardiol. 2012 Jul;60(1):18-22.4. Shimizu T, Tanaka T, Iso T et al. Azelnidipine inhibits MSX2-dependent o

5、steogenic differentiation and matrix mineralization of vascularsmooth muscle cells. Int Heart J. 2012;53(5):331-5.5. Ohyama T, Sato K, Kishimoto K et al. Azelnidipine is a calcium blocker that attenuates liver fibrosis and may increase antioxidantdefence. Br J Pharmacol. 2012 Feb;165(4b):1173-87.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021