Devimistat-CPI-613-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEDevimistatCat. No.: HY-15453CAS No.: 95809-78-2Synonyms: CPI-613分式: CHOS分量: 388.59作靶點: Others作通路: Others儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 250 mg/mL (643.35 mM)* means soluble,

2、 but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.5734 mL 12.8670 mL 25.7341 mL5 mM 0.5147 mL 2.5734 mL 5.1468 mL10 mM 0.2573 mL 1.2867 mL 2.5734 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實驗結果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄

3、清的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (5.35 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (5.35 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE3. 請

4、依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (5.35 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Devimistat (CPI-613)種硫酸類似物，可抑制丙酮酸脫氫酶 (PDH) 和 -酮戊酸脫氫酶，破壞線粒體代謝 并顯出強的抗腫瘤活性。REFERENCES1. Zachar Z, Marecek J, Maturo C et al. Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabol

5、ism and are potentanticancer agents in vivo. J Mol Med (Berl). 2011 Nov;89(11):1137-48.2. Lee KC, Shorr R, Rodriguez R et al. Formation and anti-tumor activity of uncommon in vitro and in vivo metabolites of CPI-613, a novelanti-tumor compound that selectively alters tumor energy metabolism. Drug Metab Lett. 2011 Aug;5(3):163-82.3. Safety and Effectiveness Study of CPI-613 to Treat Refractory or Relapsed Leukemia and Myelodysplastic SyndromeMcePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-37